Respiration-dependent endogenous RNA interference

By: James V. Kohl | Published on: April 14, 2017

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If you are a theorist, please take a deep breath before beginning to read this.

The speed of light on contact with water has been linked from the level of oxygen on Earth to all biodiversity via the physiology of pheromone-controlled reproduction and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in all living genera.

@jvkohl 15h15 hours ago It’s “game over” for all theorists. There’s a new game in town. https://www.kicktraq.com/projects/geniusgames/cytosis-a-cell-biology-board-game/ … It’s an evolutionary theory killer.

@jvkohl 12h12 hours ago Epigenetically-effected nucleosome repositioning sheds Dobzhansky’s light on evolution

@jhewitt123

Why are many mRNAs translated on or nearby mitochondria?

@jvkohl 15h15 hours agoThanks for asking. Because otherwise one species could evolve into another species via natural selection for virus-driven energy theft.

@jhewitt123 Replying to @jvkohl

how many times might a typical eukaryotic mRNA get translated? is it eventually degraded by RNAases? eroded from the ends?

Yes. Thanks for asking. Virus-driven energy theft degrades messenger RNA in the context of respiration and changes in pH in all cell types.

James V. Kohl‏ @jvkohl 15m15 minutes ago The change to supercoiled DNA was energy-dependent. Where did the lost energy go? I need it back to support Schroedinger’s claims from 1944.

Re: Schodinger’s claims about sunlight: Practical application of the concept of energy as information sunlight.

Vitamin C is a natural antihistamine. It destroys the molecular structure of histamine, which decreases the amount of histamine in the blood. A diet that included the ingestion of leaves from the sago palm might have helped modern human populations in what is now Central China to ecologically adapt via energy-dependent changes in base pairs that link single nucleotide polymorphisms from natural selection for codon optimality to endogenous RNA interference and DNA repair via what is know about respiration in the context of the citric acid cycle.

See also: I forgot Wendy’s last name. She was a friend from Las Vegas, Nevada who died from lung cancer at an early age (38?). We belonged to a public speaking group, which I was forced out of by my marriage in 1992, ~25 years ago.

The group was for single people only. Lung cancer has since caused the unnecessary suffering and premature death of many others because few people have learned that one energy-dependent base pair change can be linked from a single amino acid substitution to all RNA-mediated healthy longevity or from virus-driven energy theft to all pathology.

See for another example: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

The researchers linked sex differences in cell types to differences in the types of lung cancers. The differences were placed into the context of the nutrient energy-dependent metabolism of one amino acid, methionine. They suggest that methionine is essential to cell type differentiation in humans without placing that fact into the context of virus-driven energy theft, which links the degradation of messenger RNA from mutations to all pathology in all cell types of all living genera. It makes me very angry that they will not tell the truth about how energy-dependent endogenous RNA interference protects all organized genomes from virus-driven energy theft and genomic entropy. I’m beginning to wonder whether something more than ignorance is causing the misrepresentations of biologically-based cause and effect that are linked to the prevention and/or cure of cancer and all other pathology via nutritional epigenetics and the pheromone-controlled physiologoy of reproduction in all genera

.…one possibility is that metabolism of methionine is a link between LKB1 and EED. Studies with an inhibitor of S-adenosyl homocysteine hydrolase have demonstrated that decreased methionine metabolism can cause destabilization of the PRC2 components at the protein level61. Future studies will focus on identifying the link between the cellular genotype and the epigenetic identity of lung cancer cells from different subtypes of lung cancer…

Reported as: New study proves one lung cancer subtype can switch to another

“Now that we have a glimpse into the molecular mechanism of lineage switching, we can begin to learn how to manipulate this phenomenon for better therapeutic outcomes,” said Brainson.

My comment: In our 1996 Hormones and Behavior review we linked energy-dependent “lineage switching” to healthy longevity via alternative splicings of pre-mRNA and Polycomb.

Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

See also: Thanks to everyone who helped fund the end of neo-Darwinian pseudoscientific nonsense and the end of the “Big Bang” theory. Viral latency is energy-dependent, RNA-mediated, and endogenous RNA interference is biophysically constrained by the physiology of pheromone-controlled reproduction.

The anti-entropic virucidal energy of the sun will be placed into its proper context by anyone who plays this game.

`6650 backers will receive the games and the number of biologically informed serious scientists will grow exponentially.
Anyone who plans to “March for Science” on Earth Day (April 22, 2017) is likely to be asked this embarrassing question. “Where did the energy in a hydrogen atom come from?”
Their answer will lead to a second question. “Where does the energy go when it no longer sustains the life of the organism?”