March for science vs microRNAs

By: James V. Kohl | Published on: April 22, 2017

March for Science aims to counter ‘alarming’ anti-science trends

Rush Holt, a former physicist and Democratic congressman who runs the American Association for the Advancement of Science, said scientists find it appalling that “evidence has been crowded out by ideological assertions.

See: Combating Evolution to Fight Disease: March 7, 2014

Molecular biology and evolutionary biology have been separate disciplines and scientific cultures: The former is mechanistic and focused on molecules; the latter is theoretical and focused on populations. However, these domains are beginning to converge in laboratories addressing molecular mechanisms that explain how evolutionary processes work, and bring these processes to bear on medical problems such as cancer and infectious disease. Each discipline can be viewed as a missing link in the other’s description of biology, and in medicine.

Darwin probably anticipated the insemination of population genetics that led to the bastardization of his detailed observations in the “Modern Synthesis.” He politely insisted that ‘conditions of life’ be considered before natural selection.

While you were sleeping this “tipping point” was reached. The fact that it was reached on the night before the “March for Science” may have the anticipatory impact akin to that of the night before Christmas and Christmas morning if you are a creationist.

There are now more that 60,000 published works that refute the neo-Darwinian nonsense that is still being taught to unsuspecting victims of academic fraud and/or corporate greed.
See for comparison: A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis

See also: See also: “What’s new for ‘microRNA in PubMed” 1 – 20 of 41

1. Upregulation of microRNA-125b by G-CSF promotes metastasis in colorectal cancer.
2. Specific microRNA-mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein-Related Peptidase 6.
3. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.
4. Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates.

5. Genetic analysis of α-synuclein 3′ untranslated region and its corresponding microRNAs in relation to Parkinson’s compared to dementia with Lewy bodies.

6. Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives.
7. MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma.
8. MicroRNA-148a promotes apoptosis and suppresses growth of breast cancer cells by targeting B-cell lymphoma 2.
9. Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma.

10. MicroRNA signatures predict prognosis of patients with glioblastoma multiforme through the cancer genome atlas.

11. MiR-766 induces p53 accumulation and G2/M arrest by directly targeting MDM4.
12. LncRNA CHRF-induced miR-489 loss promotes metastasis of colorectal cancer via TWIST1/EMT signaling pathway.
13. Altered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients’ Smoking Status.
14. A five-miRNA expression signature predicts survival in hepatocellular carcinoma.
15. Issues in current microRNA target identification methods.
16. Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity.
17. MicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia.
18. Targeting the role of lipoprotein (a) in stroke.
19. MicroRNA-451 regulates chemoresistance in renal cell carcinoma by targeting ATF-2 gene.
20. Ultrasensitive Detection of MicroRNAs with Morpholino-Functionalized Nanochannel Biosensor.

See for comparison: Nature and nurture dictate the social structure

Our results show that where you end up in life is not only dependent where you start and how smart you are but is determined by your personality. 

See also our section on molecular epigenetics from this 1996 review. From Fertilization to Adult Sexual Behavior

All these factors affect the internal workings of the individual and intervene in structuring how the social environment might or might not modify sexual behavior. This discourse calls attention to features that are central to the so-called nature-nurture discussion.

Seeing the assault on fact-based thinking, scientists are energized.
All serious scientists have linked energy-dependent changes in metabolic networks to genetic networks. Changes in the networks angstroms to ecosystems in all living genera via alternative splicings of pre-mRNA. Virus-driven energy theft links the degradation of mRNA from mutations to all pathology via changes in the microRNA/messenger RNA balance.

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