Dr Topol: You have assembled a global collaborative engine that is exquisite in the real-time sharing of data in these Sherlockian investigations of the mutations in a virus that account for its movement. Through sequencing, we have this remarkable tool. But if not for the fact that you could assemble all of the people and parts around the world, it might not work too well, right?
Viruses do not mutate They steal the energy from host cells that prevents the biophysically constrained RNA-mediated cell type differentiation that is linked from the physiology of reproduction to all biodiversity in all living genera.
Dr Sabeti: Absolutely. I have great people in my lab who are incredibly collaborative. At every point, we think about how to reach out to others. It’s been fun. A lot of our collaborations happened when we released our data to the Web. Some of the greatest leaders around the world reached out to us and said, “Was this a mistake? Did you want to release this?” We said, “No; please play with it.”
The release of misinformation about viruses that placed them in the context of mutations linked to pathology is the game played by Pardis Sabetti, and her collaborators. These theorists claim they modeled human evolution when they failed miserably to address the facts that link virus-driven energy theft and the degradation of messenger RNA from mutations to all pathology.
These two reports (Grossman et al., 2013; Kamberov et al., 2013) tell a new short story of adaptive evolution. The story begins with what was probably a nutrient-dependent variant allele that arose in central China approximately 30,000 years ago. The effect of the allele is adaptive and it is manifested in the context of an effect on sweat, skin, hair, and teeth. In other mammals, like the mouse, the effect on sweat, skin, hair, and teeth is due to an epigenetic effect of nutrients on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones. The pheromones control the nutrient-dependent hormone-dependent organization and activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates as previously indicated. That means the adaptive evolution of the human population, which is detailed in these two reports, is also likely to be nutrient-dependent and pheromone-controlled, since there is no other model for that.
Cytosis is a worker placement game that takes place inside a Human Cell! Players utilize the organelles within a cell to collect cellular resources such as mRNA from the Nucleus, Lipids from the Smooth E.R., ATP from the Mitochondria, etc. and score points when they use these resources to complete Hormones, Receptors or Enzymes! 2 to 5 Players, Ages 10 +, Plays in 50 to 75 mins – (Shipping Aug/Sept 2017 – US, EU, CA & AU will ship from WITHIN their country / region)
I worked with John [Levy] to figure out how the HIV virus put different components together. We used the retrovirus as a model, and that formed the basis for the project.
Greg Bear carried the theme through a 30-year series of science fiction novels.
