MicroRNAs light up life

By: James V. Kohl | Published on: June 2, 2017

Summary: Every aspect of cell type differentiation or mutation-driven pathology occurs downstream from the de novo creation of energy-dependent microRNAs. That fact should be considered in all aspects of top-down causation, which must link the sun’s energy to behavior via the physiology of reproduction and chromosomal inheritance.

On a relational theory of biological systems: a natural model for complex biological behavior (5/29/17)

In this paper, we develop a natural (empirical) relational theory for describing and modeling complex biological phenomena. We have as stepping stone the assertion: function implies structure. The theory is built upon a graph’s theory structure in which a diffusion model of information takes place, and where dynamics can be investigated in order to generate steady quantifiers. In this context, we improve a seminal work by adding a free context biological importance measure given by the Shannon’s Entropy. We also introduce the concept of biological loci. Such concept stands for closely related biological agents which plays a role as an agent by itself. Our results allow us to synthesize a natural model for complex biological behavior that takes into account: system’s update, irreducibility, and exploit of the dynamical behavior mounted over a diffusion model. The model deals in final terms to its natural capacity to model plasticity and environmental changes, which has an intrinsic relationship with Shannon’s Entropy and the sort of dynamics that biological systems can display.

It’s too late for any more of this pseudoscientific nonsense about entropy and increasing organismal complexity, which is energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction.

See also: Evolution Not Only About Natural Selection but Also Improvisation, Says Israeli Scientist

Evolution, he argues, is not limited to families of plants and animals, but also occurs inside individual living things – whether they are, say, cells, plants, horses or people.

It is too late for people like him to redefine “evolution” in the context of a theory of adaptive improvisation at the level of links from energy-dependent changes in angstroms to ecosystems. All biologically informed researchers have followed the lead of the late Eshel Ben-Jacob, who realized that natural selection for energy-dependent codon optimality links what organisms eat to the physiology of their pheromone-controlled reproduction. All serious scientists have known that for more than two decades.

To start from cell type differentiation in bacteria, see: Seeking the foundations of cognition in bacteria: From Schrödinger’s negative entropy to latent information (2006)

…it is widely accepted that there is no need for some unknown laws of physics to explain cellular ontogenetic development. We take a different view and in Schrödinger’s foot steps suggest that yet unknown physics principles of self-organization in open systems are missing for understanding how to assemble the cell’s component into an information-based functioning “machine”.

If your ridiculous theory does not explain how the virus-driven degradation of messenger RNA is biophysically constrained by the physiology of nutrient-dependent pheromone-controlled reproduction in species from microbes to humans, you must start learning what serious scientists have learned during the past century.

Simply put, the last universal common ancestor had the ability to find food. That fact attests to the glory of all Creation, which starts with the Creation of sunlight. The claims of some creationists can be placed into the context of a light-activated endogenous substrate in all cell types that links energy as information to endogenous RNA-interference and all biophysically constrained biodiversity via the pheromone-controlled physiology of reproduction.

Theorists can continue to claim whatever they wish. But none of their claims make sense if they cannot link energy to healthy longevity via the physiology of reproduction and also link the virus-driven degradation of messenger RNA from mutations to all pathology.

Serious scientists have done that. See: Scientists investigate how the sense of smell works in bacteria

…the signaling and inactive states differ only very slightly at the nitrate-binding site – by 0.5-1 angstroms, which is approximately one fifth of the size of the ion itself (1 angstrom is 10-10 meters). However, when this ion binds to the sensor, it causes huge changes in the protein: The helices of different monomers begin to move in different directions, like pistons. These “pistons” transmit the small change of 0.5-1 angstroms through the membrane, and their outer ends shift by approximately 2.5 angstroms in different directions. Inside the cell, in the HAMP domain, these shifts are converted into the rotation of two parts of NarQ relative to each other. Ultimately, the positions of the output helices change by as much as 7 angstroms, thus completing the signal transmission.

Disease Awareness Months Work, Even If You Don’t Wear The Ribbon

For the people living with an illness that may lack effective treatments, much less a cure, even small increases in awareness are valuable. And that’s true whether or not anybody remembers what disease they’re supposed to be thinking about this month.

Think about this. Serious scientists have published more than 61,000 papers that link nutrient energy-dependent microRNAs to healthy longevity and virus-driven energy theft from the degradation of messenger RNA to mutations and all pathology. A PubMed search for “microRNA” and the name of the pathology you would like to cure will show you that the cure is always energy-dependent biophysically constrained viral latency.
Myasthenia gravis
Congenital Cytomegalovirus

See for comparison:


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