Methylation and the innate immune system (2)

(click to enlarge)
These results highlight the high intrinsic specificity of TMD interactions, demonstrate that a single methyl group can dictate specificity, and define the minimal chemical difference that can modulate the specificity of TMD interactions and the activity of transmembrane proteins.
RNA-directed DNA methylation is energy-dependent. The “minimal chemical difference” is linked from the quantized energy of virucidal light to all biophysically constrained biodiversity via base pair changes, single methyl groups, and fixation of amino acid substitutions in organized genomes.
See: Methylation and the Innate Immune System
I sent these two questions in advance:
1) Does what organisms eat link food energy to RNA-directed DNA methylation and all healthy longevity via fixation of amino acid substitutions and transgenerational epigenetic inheritance in the context of the physiology of pheromone-controlled reproduction in species from microbes to humans?
2) Does the virus-driven theft of quantized energy link the loss of information from impaired methylation to all pathology?
The replay is available for free until September 12, 2017
I asked about this within 10 minutes from the start of the Webinar:
Re: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of โoxidative phosphorylationโ
Did McEwen et al., (1964) link the energy-dependent creation of RNA from ATP to all biodiversity via food energy and changes in in the innate immune system and the adaptive immune system?
10 minutes later Dr. Schmitt began to discuss the ‘evolution’ of the innate immune system. He included the fact that it protects plants and animals from viruses and bacteria.
If viruses and bacteria co-evolved his comments could be placed into the context of evolution. Instead, viruses steal the nutrient energy that is required for the energy-dependent creation of the innate immune system. This fact is critical to the claims of young earth creationists, and yet it seems to be virtually ignored by anyone who places it into the context of neo-Darwinian evolution or into the context of Intelligent Design.
5 minutes later Dr. Schmitt discussed how “normal” ranges have been changed because typical populations are not “average.”
My example: Normal ranges vary with the sexual differentiation of all cell types, but this is especially pertinent to differences in RBCs and hemoglobin.
5 minutes later Dr. Schmitt provided the rationale that dictates use of nutritional support when patients are being treated for differences in pathology. He specifically mentioned methylation nutrients.
Folate and B-12 link SNPs to healthy longevity via the sulfur amino acid metabolism pathway but only when given in the correct order.
10 minutes later Dr. Schmitt linked B-12 from homocysteine to SNPs and to differences associated with the amino acid methionine.
5 minutes later Dr. Schmitt linked energy-dependent changes in base pairs to the SNPs and RNA-directed DNA methylation via amino acid substitutions in the context of transgenerational epigenetic inheritance of heterozygous or homozygous SNPs and/ or the need for supplementation. One mutated SNP was linked from deficits in methylation to 40% of patients and one mutated SNP was linked to deficits in methylation in 70% of patients.
5 minutes later Dr. Schmitt linked NAD-H (e.g., Niacinimide) to gene activation and energy-dependent RNA-mediated methylation.
3 minutes later Dr. Schmitt mentioned the Bleach Sniff Test for assessment of methylation.
“…we consider the olfactory challenging with the hypochlorite solution, which is the main ingredient in bleach, as an excellent screening test for free radical pathology.”
At the end of the free webinar, they start trying to sell their Professional Webinar Series for $19/month or $197 for the year. None of my questions were answered.
Instead, in the context of a link from the Bleach Sniff Test to the energy-dependent time-space continuum, they started with methylation instead of the energy that is required to link methylation as was done in Olfaction Warps Visual Time Perception
The webinar failed to address any aspect ofย what is known to serious scientists. See: Feedback loops link odor and pheromone signaling with reproduction
See for comparison: The Scent of Eros: Mysteries of Odor in Human Sexuality reviewed by Mark Sergeant
Conclusion
The Scent of Eros is certainly an engaging text that informs the reader about the majority of key studies performed on human olfaction. Where it is let down is a lack of supporting evidence for some of the ideas considered, and a lack of critical consideration for some of the evidence that is presented. A reader unfamiliar with olfaction research could come away from this text unaware of several key debates within the field, and take it for granted that humans do possess a functional VNO, and that the term pheromone can be applied legitimately in research concerning human olfaction. In short this lack of a critical approach undermines the validity of the bookโs contents. However it should be remembered that this book is aimed at a general audience, and as a result the authors may have felt it inappropriate to address the debates within olfaction research for such an audience. For a more academic consideration of the field by the authors, I would recommend Kohlโs more recent review paper (Kohl et al, 2001), which addresses the issues outlined above.
Kohl et al, (2001) is Human pheromones: integrating neuroendocrinology and ethology
Food odors and the metabolism of food to pheromones have repeatedly been linked from RNA-directed DNA methylation to all extant biodiversity in reports like this one: Feedback loops link odor and pheromone signaling with reproduction
There is no excuse for placing that fact into the context of ridiculous theories about enhancers, promoters, or any other claims that fail to link energy from the creation of microRNAs and changes in the microRNA/messenger RNA balance to healthy longevity.
But see: PAF1 regulation of promoter-proximal pause release via enhancer activation, which was reported as:
“Scientists discover mechanism behind ‘paused’ genes” September 7, 2017
Northwestern Medicine scientists have discovered the mechanism driving a protein that influences transcription, a crucial step in gene expression. The study, published in Science, could lead to drugs that control faulty gene expression, a precursor to cancer and other disease.
Gene expression is energy-dependent and RNA-mediated in the context of changes in the microRNA/messenger RNA balance that link the efforts of everyone who is Combating Evolution to Fight Disease to the prevention of virus-driven messenger RNA degradation from mutations to all pathology.
Those who are Combating Evolution to Fight Disease are fighting against pseudoscientists who use terms like enhancers, promoters, spacers QTLs et al., in there attempts to deliberately obfuscate what in known to all serious scientists.
See: On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires
The dynamic evolution of the CRISPR loci, both in their โhardwareโ (adaptation and effector enzymatic machinery) and โsoftwareโ (spacer repertoires), provides a valuable opportunity to track virus-host coevolution (36).
There is no such thing as virus-host coevolution except in the context of mathematical models that have no explanatory power whatsoever because they do not link energy or energy theft to all biodiversity.
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Predictable idiosyncratic evolved convergence
3 MIN READ
0
The human virome (revisited)
4 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
Pheromone-controlled autophagy
4 MIN READ
0
Hecatombic non-specific mutation-driven evolution
5 MIN READ
0
Hecatombic evolution via oncocers and oncohistones
9 MIN READ
0
Did evolution autophosphorylate your kinases? (2)
5 MIN READ
1
Nutrient-dependent autophagy
3 MIN READ
0
Life is energy-dependent task management (2)
3 MIN READ
0
Life is energy-dependent task management
3 MIN READ
0
Hypothesis free pseudoscience vs facts (2)
5 MIN READ
0
Hypothesis free pseudoscience vs facts (1)
5 MIN READ
0
The last RNA-mediated theory killer
< 1 MIN READ
0
Base pairs, olfaction and RNA thermometers
4 MIN READ
0
Chromatin: The structure of DNA (2)
8 MIN READ
0
Chromatin: The structure of DNA
6 MIN READ
0
Hydrogen-atom energy in DNA base pairs
6 MIN READ
0
DNA repair via junk DNA (2)
5 MIN READ
0
The Aquatic Ape / Waterside Ape divergence
6 MIN READ
0
Light energy-dependent active motifs
6 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
Displays of ecological adaptation (2)
3 MIN READ
0
DNA repair via junk DNA (1)
5 MIN READ
0
Unconstrained mutations, Zika virus, Kallmann’s syndrome
4 MIN READ
0
Linking RNA structure to function
3 MIN READ
0
Protecting 4 billion people from virus-driven entropy
< 1 MIN READ
0
Increased soil pH and nutrient availability
4 MIN READ
0
Energy-dependent cellular communication
3 MIN READ
0
Virus-driven energy theft: honeybee model
3 MIN READ
0
Anthetical conclusions (2)
5 MIN READ
0
Anthetical conclusions
3 MIN READ
0
Non-random pheromone-controlled cell type differentiation
3 MIN READ
0
RNAi: From magic bullet to billion dollar baby
4 MIN READ
0
Co-evolution and co-speciation replace neo-Darwinian nonsense
4 MIN READ
0
GC-rich neo-Darwinian train wreck
5 MIN READ
0
Food supplement or licensed immunostimulant?
6 MIN READ
0
Virus-driven downsizing of the human brain (3)
4 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity
4 MIN READ
0
The Origin of Information (2)
6 MIN READ
0
Light ‘drives’ adaptation; nothing ‘drives’ evolution
6 MIN READ
0
Invisible dark matter
< 1 MIN READ
0
Funding the Human Genome Project-Write
2 MIN READ
0
RNA-mediated programming of E.coli
< 1 MIN READ
0
Did โNatureโ kill Steve Jobs? (2)
6 MIN READ
0
Did “Nature” kill Steve Jobs?
3 MIN READ
0
Virus-driven downsizing of the human brain (2)
< 1 MIN READ
0
Virus altered thermodynamic stability
< 1 MIN READ
0
MicroRNAs and sexual orientation
8 MIN READ
0
RNA methylation, learning, memory and behavior,
< 1 MIN READ
0
Innate immunity and multiplexing
7 MIN READ
0
RNA methylation (2)
7 MIN READ
0
Amino acids and virus penetration
3 MIN READ
0
Major transition ends use of silly theories
5 MIN READ
0
Masters of deception about nature (2)
7 MIN READ
0
Masters of deception about nature
8 MIN READ
0
The Mind’s Eyes (revisited)
10 MIN READ
0
Cracking the Olfactory Code?
5 MIN READ
0
RNA methylation, behavior, and disease
6 MIN READ
0
Energy-dependent RNA methylation (9)
2 MIN READ
0
Energy-dependent RNA methylation (10)
4 MIN READ
0
Energy-dependent RNA methylation (7)
7 MIN READ
0
Energy-dependent RNA methylation (6)
9 MIN READ
0
Energy-dependent RNA methylation (3)
10 MIN READ
0
Energy-dependent RNA methylation (1)
6 MIN READ
0
Secular humanism and ecoterrorism
4 MIN READ
0
Thermotolerance and longevity (2)
3 MIN READ
0
War Games: False Flag Terrorism
5 MIN READ
0
Energy-dependent biodiversity (4)
4 MIN READ
0
Energy-dependent biodiversity (3)
7 MIN READ
0
The tipping point? 50,000 publications (3)
6 MIN READ
0
The tipping point? 50, 000 publications
4 MIN READ
0
Countdown to Genetics and Genomics
< 1 MIN READ
0
Energy-dependent creation and entropy
4 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (5)
6 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics
9 MIN READ
0
Wasted Templeton Funding (4)
3 MIN READ
0
MicroRNAs and/or QTLs: Who buried what?
2 MIN READ
0
RNA splicing, genetic variation, and disease
2 MIN READ
0
Wasted Templeton Funding (3)
2 MIN READ
0
Wasted Templeton Funding (2)
2 MIN READ
0
From nothing to life and death everywhere
5 MIN READ
0
Molecular Diagnostics: What is unprotected life (4)
2 MIN READ
0
Molecular Microbial Ecology
8 MIN READ
0
Molecular Diagnostics: What is unprotected life? (2)
7 MIN READ
0
Virus-driven sex differences?
2 MIN READ
0
Half truths support theories without facts
4 MIN READ
0
Ricki Lewis’ Time Machine (3)
5 MIN READ
0
Creating nutrient-dependent life with enough genes to survive (2)
3 MIN READ
0
Confusing effects and affects of visual input
2 MIN READ
0
Ignore the evidence: Rachel Feltman
5 MIN READ
0
Energy-dependent purpose vs teleophobic telorexia
12 MIN READ
0
Virus-driven disorder prevention and health promotion
6 MIN READ
0
Energy dependent RNA-mediated immunity (4)
6 MIN READ
0
Energy dependent RNA-mediated immunity (3)
8 MIN READ
0
Energy-dependent RNA-mediated immunity (1)
10 MIN READ
0
Science vs semantics
4 MIN READ
0
Hybrids: making microbes and Democrats into monkey’s uncles?
11 MIN READ
0
The Light and Darkness of “Evolution 2.0”
11 MIN READ
0
Cancer: Evolution 2.0’s Blind Spot
13 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (6)
7 MIN READ
0
Virus-perturbed alternative splicings
3 MIN READ
0
Blood test links atoms to ecosystems
2 MIN READ
0
Another failed rescue attempt
5 MIN READ
0
Ecological genomics: teleophobes respond (too late)
10 MIN READ
0
Ecological law, cooperation, and DNA repair
4 MIN READ
0
Finding peace and ฯ in the light of H bond energy (2)
8 MIN READ
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3 MIN READ
0
Finding peace and ฯ in the light of H bond energy
5 MIN READ
0
Perry Marshall: too much information for atheist PZ Myers
3 MIN READ
0
Epigenetic (re)programming of behavior (2)
6 MIN READ
0
Epigenetic (re)programming of behavior
4 MIN READ
0
Neo-Darwinian sink testing
2 MIN READ
0
NORAD: air defense and defense against genomic entropy
7 MIN READ
0
Life history transitions and RNA-mediated survial
2 MIN READ
0
Does metabolism link beneficial mutations to cancer?
10 MIN READ
0
RNA-mediated theory killers (4)
9 MIN READ
0
RNA-mediated theory killers (3)
7 MIN READ
0
RNA-mediated regulatory mechanisms link microbes to humans (3)
5 MIN READ
0
Nutrient-dependent trophic analogs (2)
6 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
Natural cooperation and Evolution 2.0
6 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (5)
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (3)
8 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs
9 MIN READ
0
Sulfated steroids and RNA-mediated identity codes
< 1 MIN READ
0
Life and death predicted by DNA methylation
3 MIN READ
0
Nutrient-dependent trophic analogs
3 MIN READ
0
Stress-perturbed mitochondrial dysfunction (2)
5 MIN READ
0
Behavioral Immune System model
4 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Neuroplasticity
4 MIN READ
0
Sensationalizing no new mechanism
2 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
Models are not theories (2)
2 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
FREE* SAMPLE: Histone modification
4 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Mystery machine vs model
2 MIN READ
0
Epigenetic inheritance of stress-perturbed protein folding
2 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Checkpoint checkmate: viruses lose if conditions of life win
< 1 MIN READ
0
Cancer: forward and reverse
2 MIN READ
0
Virucidal effects on ecological speciation
5 MIN READ
0
Nutrient-dependent RNA-directed DNA methylation
5 MIN READ
0
Viruses come alive: Tree of life pseudoscience
6 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Pathology: Eating and breathing viruses
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine (3)
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
Information and communication (2)
6 MIN READ
0
Olfaction & the octopus and human genomes (2)
4 MIN READ
0
Viruses, amino acids, and somatic cell types
4 MIN READ
0
Hematopoiesis and practopoiesis
4 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
The RNA-mediated sum of our parts
2 MIN READ
0
Is SUMOylation RNA-directed DNA methylation? (revisited)
4 MIN READ
0
The sum of our RNA-mediated parts
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
An unprecedented view of genomic complexity
2 MIN READ
0
Is SUMOylation RNA-directed DNA methylation?
2 MIN READ
0
“First” evidence
5 MIN READ
0
Creating and maintaining the human virome
2 MIN READ
0
Missing a fact: microRNAs are genomic biomarkers
4 MIN READ
1
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Epigenetics vs the fossil record
4 MIN READ
0
Re-inventing a completely new thing
4 MIN READ
0
The Darwin Code by Greg Bear
13 MIN READ
0
Genetic chimerism and ecological adaptation
4 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
Life: conserved ion and amino acid transporters
3 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
Correctly modeling biological energy
2 MIN READ
0
Virus-driven cell type differentiation
2 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
Are viruses microRNAs?
3 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
Understanding physical forces of ecological variation and adaptation
< 1 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
Different physical locations and different molecular mechanisms of health and disease
2 MIN READ
0
Evolving DNA before RNA
4 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3 MIN READ
0
Ecologically linked adapted ants and brains
2 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Pheromones and multicellularity
< 1 MIN READ
0
Is oxygen required for sensing nutrient chemicals and pheromones?
2 MIN READ
0
Pheromones: from microbes to man
< 1 MIN READ
0
Human skull study causes evolutionary headache
< 1 MIN READ
0