Methylation and the innate immune system (2)

By: James V. Kohl | Published on: September 7, 2017

These results highlight the high intrinsic specificity of TMD interactions, demonstrate that a single methyl group can dictate specificity, and define the minimal chemical difference that can modulate the specificity of TMD interactions and the activity of transmembrane proteins.

RNA-directed DNA methylation is energy-dependent. The “minimal chemical difference” is linked from the quantized energy of virucidal light to all biophysically constrained biodiversity via base pair changes, single methyl groups, and fixation of amino acid substitutions in organized genomes.

See: Methylation and the Innate Immune System

I sent these two questions in advance:
1) Does what organisms eat link food energy to RNA-directed DNA methylation and all healthy longevity via fixation of amino acid substitutions and transgenerational epigenetic inheritance in the context of the physiology of pheromone-controlled reproduction in species from microbes to humans?
2) Does the virus-driven theft of quantized energy link the loss of information from impaired methylation to all pathology?
The replay is available for free until September 12, 2017
I asked about this within 10 minutes from the start of the Webinar:

Re: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of โ€œoxidative phosphorylationโ€

Did McEwen et al., (1964) link the energy-dependent creation of RNA from ATP to all biodiversity via food energy and changes in in the innate immune system and the adaptive immune system?

10 minutes later Dr. Schmitt began to discuss the ‘evolution’ of the innate immune system. He included the fact that it protects plants and animals from viruses and bacteria.

If viruses and bacteria co-evolved his comments could be placed into the context of evolution. Instead, viruses steal the nutrient energy that is required for the energy-dependent creation of the innate immune system. This fact is critical to the claims of young earth creationists, and yet it seems to be virtually ignored by anyone who places it into the context of neo-Darwinian evolution or into the context of Intelligent Design.

5 minutes later Dr. Schmitt discussed how “normal” ranges have been changed because typical populations are not “average.”
My example: Normal ranges vary with the sexual differentiation of all cell types, but this is especially pertinent to differences in RBCs and hemoglobin.

5 minutes later Dr. Schmitt provided the rationale that dictates use of nutritional support when patients are being treated for differences in pathology. He specifically mentioned methylation nutrients.

Folate and B-12 link SNPs to healthy longevity via the sulfur amino acid metabolism pathway but only when given in the correct order.

10 minutes later Dr. Schmitt linked B-12 from homocysteine to SNPs and to differences associated with the amino acid methionine.

5 minutes later Dr. Schmitt linked energy-dependent changes in base pairs to the SNPs and RNA-directed DNA methylation via amino acid substitutions in the context of transgenerational epigenetic inheritance of heterozygous or homozygous SNPs and/ or the need for supplementation. One mutated SNP was linked from deficits in methylation to 40% of patients and one mutated SNP was linked to deficits in methylation in 70% of patients.

5 minutes later Dr. Schmitt linked NAD-H (e.g., Niacinimide) to gene activation and energy-dependent RNA-mediated methylation.

3 minutes later Dr. Schmitt mentioned the Bleach Sniff Test for assessment of methylation.

“…we consider the olfactory challenging with the hypochlorite solution, which is the main ingredient in bleach, as an excellent screening test for free radical pathology.”

At the end of the free webinar, they start trying to sell their Professional Webinar Series for $19/month or $197 for the year. None of my questions were answered.

Instead, in the context of a link from the Bleach Sniff Test to the energy-dependent time-space continuum, they started with methylation instead of the energy that is required to link methylation as was done in Olfaction Warps Visual Time Perception

The webinar failed to address any aspect ofย  what is known to serious scientists. See: Feedback loops link odor and pheromone signaling with reproduction

See for comparison: The Scent of Eros: Mysteries of Odor in Human Sexuality reviewed by Mark Sergeant

Conclusion

The Scent of Eros is certainly an engaging text that informs the reader about the majority of key studies performed on human olfaction. Where it is let down is a lack of supporting evidence for some of the ideas considered, and a lack of critical consideration for some of the evidence that is presented. A reader unfamiliar with olfaction research could come away from this text unaware of several key debates within the field, and take it for granted that humans do possess a functional VNO, and that the term pheromone can be applied legitimately in research concerning human olfaction. In short this lack of a critical approach undermines the validity of the bookโ€™s contents. However it should be remembered that this book is aimed at a general audience, and as a result the authors may have felt it inappropriate to address the debates within olfaction research for such an audience. For a more academic consideration of the field by the authors, I would recommend Kohlโ€™s more recent review paper (Kohl et al, 2001), which addresses the issues outlined above.

Kohl et al, (2001) is Human pheromones: integrating neuroendocrinology and ethology
Food odors and the metabolism of food to pheromones have repeatedly been linked from RNA-directed DNA methylation to all extant biodiversity in reports like this one: Feedback loops link odor and pheromone signaling with reproduction
There is no excuse for placing that fact into the context of ridiculous theories about enhancers, promoters, or any other claims that fail to link energy from the creation of microRNAs and changes in the microRNA/messenger RNA balance to healthy longevity.
But see: PAF1 regulation of promoter-proximal pause release via enhancer activation, which was reported as:

“Scientists discover mechanism behind ‘paused’ genes” September 7, 2017

Northwestern Medicine scientists have discovered the mechanism driving a protein that influences transcription, a crucial step in gene expression. The study, published in Science, could lead to drugs that control faulty gene expression, a precursor to cancer and other disease.

Gene expression is energy-dependent and RNA-mediated in the context of changes in the microRNA/messenger RNA balance that link the efforts of everyone who is Combating Evolution to Fight Disease to the prevention of virus-driven messenger RNA degradation from mutations to all pathology.
Those who are Combating Evolution to Fight Disease are fighting against pseudoscientists who use terms like enhancers, promoters, spacers QTLs et al., in there attempts to deliberately obfuscate what in known to all serious scientists.
See: On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

The dynamic evolution of the CRISPR loci, both in their โ€œhardwareโ€ (adaptation and effector enzymatic machinery) and โ€œsoftwareโ€ (spacer repertoires), provides a valuable opportunity to track virus-host coevolution (36).

There is no such thing as virus-host coevolution except in the context of mathematical models that have no explanatory power whatsoever because they do not link energy or energy theft to all biodiversity.
 
 


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