From base editing to RNA editing (5)
Dopamine-mediated behavioral are effected by COMT Val158Met function, which
“… is known to be affected by a functional single nucleotide polymorphism (SNP) in COMT (G-to-A base-pair substitution) leading to a methionine (Met) valine (Val) substitution at codons 108/158 (COMT Val158Met). Carriers of the Met allele have been found to display a fourfold decrease in enzymatic activity compared to Val allele carriers going along with an increase of prefrontal DA activity (Lachman et al. 1996; Lotta et al. 1995).”
The fact that one energy-dependent base-pair substitution and one RNA-mediated amino acid substitution can be linked to behavioral transitions via dopamine links epigenetics and genetics.
All serious scientists know that and some of them have been laughing at pseudoscientists for several decades. See from 10 December 2014:
See also: Structural diversity of supercoiled DNA
Tell the pseudoscientists and journalists who report ridiculous claims to stop treating us all as if we will always be biologically uninformed science idiots — unless that’s what you want to be when you grow up.
See for comparison: Cytosis: A Cell Biology Board Game
A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!