Kinetically Stable Thermodynamically Activated Cell Metabolism (2)

By: James V. Kohl | Published on: December 25, 2017

Conclusion: The link from food to pheromones requires a link from the energy-dependent creation of enzymes to the functional structure of supercoiled DNA.
See:  Evolution’s Achilles’ Heels” (DVD)

…fifteen Ph.D. scientists collaborated to produce a coordinated, coherent, powerful argument. All of the contributors received their doctorates from similar secular universities as their evolutionary counterparts. Each is a specialist in a field relevant to the subject: Natural selection, origin of life, geology, genetics, radiometric dating, the fossil record, cosmology, and ethics.

Natural selection for energy-dependent codon optimality in the context of the physiology of pheromone-controlled reproduction, which must be linked to fixation of RNA-mediated amino acid substitutions in supercoiled DNA is evolution’s Achille’s Heel. The facts about energy-dependent RNA-mediated amino acid substitutions link the creation of the sun’s anti-entropic virucidal energy from the creation of ATP to the creation of RNA.
The virus-driven degradation of messenger RNA links the theft of quantized energy to all pathology via losses of fixed amino acid substitutions in the organized genomes of species from microbes to humans.
See: Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition
See also: Epigenetics and Codon Usage of the Histone Genes in 12 Drosophila Species

…recent findings regarding codon usage for canonical and replacement types of histones are outlined for study of the evolution of these histone genes and their epigenetic regulation in Drosophila.

Histone genes do not evolve. Links from the epigenetic landscape to the physical landscape of supercoiled DNA are biophysically constrained by the pheromone-controlled physiology of reproduction. The physiology of reproduction protects all living genera from the virus-driven degradation of  messenger RNA. See for comparison: A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases

…miRNA functions can be altered by single-point mutations in miRNA target and epigenetic silencing of transcription units. There are numerous molecular targets for miRNA as degradation by nuclease and phosphodiesterase. Thus, miRNA has potential applications in disease diagnosis along with therapy, but the mechanisms involved in miRNA systems and its targeted delivery of miRNA are much more important to achieve its therapeutic applications.

The molecular mechanisms that link energy-dependent base editing to microRNA editing and RNA editing to fixation of RNA-mediated amino acid substitutions have been detailed in their entirety. It makes no difference whether the biophysically constrained virucidal energy of life (i.e., sunlight) is represented in the context of cybersecurity or represented in our protection from the virus-driven degradation of messenger RNA.
Computer viruses are linked to virus-driven energy theft via metaphors. Serious scientists have linked the metaphors from quantum computing to mutations and all pathology via reports that link base editing to microRNA editing. MicroRNA editing links RNA editing from energy-dependent fixation of RNA-mediated amino acid substitution to all morphological and behavioral diversity in all living genera via differences in the amino acids of different cell types.
In chapter 10 of Surely You’re Joking, Mr. Feynman!,  A Map of the Cat?: Richard Feynman presciently linked energy theft from mutations in phages via changes in amino acids and increased virulence. He was not joking.
People who are more interested in cybersecurity than the energy-dependent biophysically constrained security of their organized genomes may want to see this, first:
See: Promises and Challenges in Continuous Tracking Utilizing Amino Acids in Skin Secretions for Active Multi-Factor Biometric Authentication for Cybersecurity Epublication on 10 May 2017. Posted to arxiv as  on 22 Sep 2017

Figure 1. Biocatalytic cascade for optical detection of three amino acids, using two detection pathways: (A) measurement of NADH at 340 nm, and (B) conversion of NADH to a visible color (formazan) via NBT/PMS which is observable at 580 nm.

Reported on 10 Nov 2017 as: Chemist proposes ‘sweat analysis’ to better secure electronics

The approach relies on analyzing skin secretions – or sweat – to build an amino acid profile that is unique to the devices’ owner.

The approach that chemists used was linked to the the fixation of amino acid substitutions in skin cells.  They confirmed that what we eat is metabolized to our species-specific pheromones in the context of amino acid substitutions in the cell types of all individuals of all species. The amino acid substitutions stabilize the organized genomes of all living genera. That fact links the metabolism of food to pheromones that biophysically constrain the transgenerational epigenetic inheritance of pathology.
The clarity of how food odors and pheromones link feedback loops from the physiology of reproduction to healthy longevity increases when something is missing.
Chemists know, when an enzyme is missing, but they cannot always explain what they know to non-chemists. See for comparison:
But see: A mammalian blood odor component serves as an approach-avoidance cue across phylum border – from flies to humans

The omnipresent adaptation to E2D indicates that the selection pressure for this chemical cue is preserved through evolution. This can shed light on human evolution, our formation as a species.

The adaptation, which requires the food energy-dependent creation of an enzyme cannot be linked to human evolution. That’s the difference between a mutation and an amino acid substitution.

Taken together, our results strongly suggest that E2D is a blood signature substance that serves as an approach-avoidance cue across phylum borders; it elicits approach responses in blood-feeding invertebrates as well as in mammalian predators, while eliciting avoidance behavior in mammalian prey species. These results demonstrate the existence of a cross-species food- and alarm cue that affects behavior in both human and non-human animals alike.

The claims in Feedback loops link odor and pheromone signaling with reproduction attest to what is known to serious scientists about “…a cross-species food- and alarm cue that affects behavior in both human and non-human animals alike. The link from food to pheromones requires a link from the energy-dependent creation of enzymes to the functional structure of supercoiled DNA.

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