Kinetically Stable Thermodynamically Activated Cell Metabolism (5)

(click to enlarge)
Summary: Remember, the kinetically stable thermodynamic biocatalytic cascade for optical detection of three amino acids used two detection pathways that linked a measurement of UV light and NADH at 340 nm to the conversion of NADH to a visible color, which was observable at 580 nm. That fact refutes all claims about the evolution of amino acids, the evolution of proteins, and the evolution of any species. The light energy-dependent RNA-mediated amino acid substitutions are biophysically constrained by the physiology of reproduction in species from microbes to humans.
Additional historical perspective:
1999 How The Nose Knows: Research On Smell Boosted
The sense of smell, notes LSU biology professor John Caprio, originally evolved to detect water-soluble chemicals like amino acids. The ability to detect volatiles in air is an adaptation of the original mechanism.
The difference between evolution and adaptation has become clear. Simply put, Evolutionists Cannot Account for the Origin of the Sense of Smell That fact was brought to your attention from an Islamic creationist. If you despise any link to any religion, stop reading now. Others, see for comparison: Soil bacteria, bulls, cows, microRNAs, and mammary glands.
I wrote:
No experimental evidence of biologically-based cause and effect links anything to the evolution of anything else. Quantum physics links the de novo creation of olfactory receptor genes to all biologically-based cause and effect. All experimental evidence links the sun’s biological energy from top-down causation to biophysically constrained RNA-mediated protein folding chemistry via amino acid substitutions in organized genomes, which link behavior and supercoiled DNA to protection from virus-driven energy theft and genomic entropy.
For comparison, see1999 Did God Make Pathogenic Viruses?
Pathogenesis is evidence of something gone wrong, a mutation or the accidental movement of genes, and not evidence of a system deliberately designed to cause human disease and suffering.
I was blindsided by the change in the Institute for Creation Research’s position on the creation of viruses.
2017 Celebrate Your Inner Virus
It is important that we understand the design present in viruses because God made them. All creatures of our God demonstrate his handiwork, and viruses are no different.
The virus-driven degradation of messenger RNA to mutations and via the loss of amino acids in differentiated cell types.
See: A universal trend of amino acid gain and loss in protein evolution
The energy-dependent RNA-mediated creation of differentiated cell types has consistently been placed into the context of pheromone-controlled biophysically constrained amino acid gains in the organized genomes of all living genera. The virus-driven theft of quantized energy is rarely linked to the loss of the amino acids. Instead, this ridiculous claim is made:
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
See for comparison, the simplicity of this claim:The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.
The change in the single amino acid near the receptor binding site is a clear example of how the virus-driven theft of quantized energy as information is linked from mutations to all pathology in all living genera. That fact can be compared to claims that link the creation of the sun’s anti-entropic virucidal energy from the physiology of pheromone-controlled reproduction to ecological adaptations and all biodiversity.
See: Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system
Genome resequencing revealed a single-nucleotide point mutation in ntrB in strain AR2S, causing an amino acid substitution within the PAS domain of the histidine kinase sensor NtrB [Thr97→Pro97 (T97P)] (13). The fast-spreading strain AR2F had acquired an additional point mutation in the σ54-dependent EBP gene ntrC, which alters an amino acid (R442C) within the DNA binding domain (Table 1 and table S2).
The authors referred to an energy-dependent base pair change and the amino acid substitutionThr97→Pro97 (T97P) as if the substitution resulted from a single-nucleotide point mutation. Next, they claimed an additional point mutation alters an amino acid (R442C) within the DNA binding domain. R442C is an energy-dependent C>T base pair change.
See for an example of deliberate obfuscation: AA mutation p.R442C (Substitution – Missense, position 442, R➞C)
CDS mutation c.1324C>T (Substitution, position 1324, C➞T)
Two energy-dependent changes in base pairs were linked to the pheromone-controlled physiology of reproduction in P. fluorescens, which fluoresces on exposure to UV light. That fact is the clearest experimental evidence that UV light energy was the source of the energy required to link the base pair changes to the amino acid substitution that stabilized the reorganized genome of the organism that resurrected its flagellum over the weekend.
Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism (revisited)
Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose of the catabolic arms of metabolism and then drive many anabolic pathways. Such analyses largely leave out how and why ATP, NADH, and acetyl-CoA (Figure 1) at the molecular level play such central roles.
Remember, the kinetically stable thermodynamic biocatalytic cascade for optical detection of three amino acids used two detection pathways that linked a measurement of UV light and NADH at 340 nm to the conversion of NADH to a visible color, which was observable at 580 nm. That fact refutes all claims about the evolution of amino acids, the evolution of proteins, and the evolution of any species. The light energy-dependent RNA-mediated amino acid substitutions are biophysically constrained by the physiology of reproduction in species from microbes to humans. The facts of life have now been linked to Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism
In the context of one energy-dependent base pair change and one RNA-mediated amino acid substitution, I linked the ingestion of sago palm-like leaves to the increased level of endogenous vitamin C and cell type stability in a modern human population via the mouse model. One base pair change and one amino acid substitution exemplified how top-down causation and bottom-up effects must be linked from what organisms eat to the physiology of pheromone-controlled reproduction and biophysically constrained viral latency.
Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
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0
Organic Compounds and the Miracle of Smell and Taste
7 MIN READ
0
Cancer: Evolution 2.0’s Blind Spot
13 MIN READ
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Ricki Lewis’ Time Machine (2)
6 MIN READ
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Virus-perturbed alternative splicings
3 MIN READ
0
Blood test links atoms to ecosystems
2 MIN READ
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Another failed rescue attempt
5 MIN READ
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Amino acid substitutions, stress, and human behavior
3 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
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Assumptions prove ignorance (2)
5 MIN READ
0
Epigenetic (re)programming of behavior
4 MIN READ
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Assumptions prove ignorance
5 MIN READ
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Did Dobzhansky see the UV light of creation?
10 MIN READ
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RNA-mediated theory killers (6) (7) (8) (9) (10)
5 MIN READ
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Does metabolism link beneficial mutations to cancer?
10 MIN READ
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RNA-mediated theory killers (5)
2 MIN READ
0
Essential pseudoscientific concepts of atheism
3 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
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Natural cooperation and Evolution 2.0
6 MIN READ
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A two-faced protein enables RNA-mediated DNA repair (2)
4 MIN READ
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Teaching the biologically uninformed
3 MIN READ
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Hydrogen-Atom Transfer in DNA Base Pairs
9 MIN READ
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A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Nutrient-dependent trophic analogs
3 MIN READ
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Stress-perturbed mitochondrial dysfunction (2)
5 MIN READ
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Stress-perturbed mitochondrial dysfunction
4 MIN READ
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Understanding cell type differentiation
3 MIN READ
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Let there be anti-entropic light (3)
6 MIN READ
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Theorists can’t understand biology
6 MIN READ
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Models are not theories (3)
3 MIN READ
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Too complex for the Complex Biological Systems Alliance
4 MIN READ
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Virus, transposon and plasmid evolution
< 1 MIN READ
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MicroRNA-encoded behavior
7 MIN READ
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Can veterans and other prisoners escape pseudoscience?
2 MIN READ
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RNA central and RNA-mediated.com
6 MIN READ
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Ecological speciation. Get it, theorists?
< 1 MIN READ
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Skip the politics; embrace the facts
5 MIN READ
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Neo-Darwinian logic is nonsense
3 MIN READ
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Epigenetic inheritance of stress-perturbed protein folding
2 MIN READ
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Preventing genomic entropy
4 MIN READ
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Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Metaphysical science vs theory
4 MIN READ
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Mechanisms of stress: from genes to cancer
9 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
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Theorists have not seen the light
4 MIN READ
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A 5-10K comparison of design principles to evolution
3 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Natural selection: an anti-entropic force?
2 MIN READ
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Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
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“New” quantum biology. Pirating the old
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
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Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
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The “great filter” is an epigenetic trap
4 MIN READ
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Thermodynamic constraints did not evolve
3 MIN READ
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The stability of organized genomes (3)
3 MIN READ
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Viruses, amino acids, and somatic cell types (3)
9 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
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Easy editing: Reinventing our RNA world
3 MIN READ
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Riding the wrong direction
3 MIN READ
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RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
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MicroRNA – controlled ecological adaptations
5 MIN READ
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“New” epigenetic mechanism for lifelong learning?
3 MIN READ
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microRNAs and memory: Why trust a theory?
2 MIN READ
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Iron, ferritin, thyroxine
2 MIN READ
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RNA-mediated development
2 MIN READ
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microRNAs, glycosylation, and genomes
4 MIN READ
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Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
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Pattern recognition: biogeochemical structure and function
5 MIN READ
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Informing the biologically uninformed
< 1 MIN READ
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Batch effect vs epigenetic effects
3 MIN READ
0
Missing a fact: microRNAs are genomic biomarkers
4 MIN READ
1
Vitamin B3 and DNA repair
4 MIN READ
0
Targeting theories to fight disease
2 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Five years of Ferguson
2 MIN READ
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Virus-driven cancer treatment and prevention
2 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
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Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
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Protein isoforms do not evolve
3 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
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How to find a “holy grail” under your nose
3 MIN READ
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MicroRNAs and the exposome (2)
< 1 MIN READ
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MicroRNAs and the exposome
5 MIN READ
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Thermodynamics and protein folding landscapes
2 MIN READ
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Feedback loops link insects to human brains
2 MIN READ
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Mutisensory integration: watching the paradigm shift
12 MIN READ
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Silencing genes and serious scientists
3 MIN READ
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Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Too many targets for theories
3 MIN READ
0
Creating nothing but a theory
4 MIN READ
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Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
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Correctly modeling biological energy
2 MIN READ
0
Questions about life’s diversity
21 MIN READ
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UV-light mutations and gene loss (not gain)
5 MIN READ
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Luis P. Villarreal tells it like it is
3 MIN READ
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Two types of microRNA are not double agents
2 MIN READ
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What about birds?
5 MIN READ
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RNA directed DNA methylation and cell types
4 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
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Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
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Imagining that data historically supports evolutionary theory
7 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
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Are viruses microRNAs?
3 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
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The future of physics predicts no future for evolutionary theory
3 MIN READ
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Glycine and GnRH: Am I being pedantic?
4 MIN READ
0
Eliminating correlations from evolutionary ecology
6 MIN READ
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Evolutionary theorists justify fear of the Ebola viruses
2 MIN READ
0
RNA-mediated genetic engineering (Part 3)
< 1 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
Cell-type differentiation
2 MIN READ
0
Darwinian theories vs Darwin's facts
2 MIN READ
0