Kinetically Stable Thermodynamically Activated Cell Metabolism (5)

By: James V. Kohl | Published on: December 25, 2017

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Summary: Remember, the kinetically stable thermodynamic biocatalytic cascade for optical detection of three amino acids used two detection pathways that linked a measurement of UV light and NADH at 340 nm to the conversion of NADH to a visible color, which was observable at 580 nm. That fact refutes all claims about the evolution of amino acids, the evolution of proteins, and the evolution of any species. The light energy-dependent RNA-mediated amino acid substitutions are biophysically constrained by the physiology of reproduction in species from microbes to humans.
Additional historical perspective:
1999 How The Nose Knows: Research On Smell Boosted

The sense of smell, notes LSU biology professor John Caprio, originally evolved to detect water-soluble chemicals like amino acids. The ability to detect volatiles in air is an adaptation of the original mechanism.

The difference between evolution and adaptation has become clear. Simply put, Evolutionists Cannot Account for the Origin of the Sense of Smell That fact was brought to your attention from an Islamic creationist. If you despise any link to any religion, stop reading now. Others, see for comparison: Soil bacteria, bulls, cows, microRNAs, and mammary glands.
I wrote:

No experimental evidence of biologically-based cause and effect links anything to the evolution of anything else. Quantum physics links the de novo creation of olfactory receptor genes to all biologically-based cause and effect. All experimental evidence links the sun’s biological energy from top-down causation to biophysically constrained RNA-mediated protein folding chemistry via amino acid substitutions in organized genomes, which link behavior and supercoiled DNA to protection from virus-driven energy theft and genomic entropy.

For comparison, see1999 Did God Make Pathogenic Viruses?

Pathogenesis is evidence of something gone wrong, a mutation or the accidental movement of genes, and not evidence of a system deliberately designed to cause human disease and suffering.

I was blindsided by the change in the Institute for Creation Research’s position on the creation of viruses.
2017 Celebrate Your Inner Virus

It is important that we understand the design present in viruses because God made them. All creatures of our God demonstrate his handiwork, and viruses are no different.

The virus-driven degradation of messenger RNA to mutations and via the loss of amino acids in differentiated cell types.
See: A universal trend of amino acid gain and loss in protein evolution
The energy-dependent RNA-mediated creation of differentiated cell types has consistently been placed into the context of pheromone-controlled biophysically constrained amino acid gains in the organized genomes of all living genera. The virus-driven theft of quantized energy is rarely linked to the loss of the amino acids. Instead, this ridiculous claim is made:

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

See for comparison, the simplicity of this claim:The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.
The change in the single amino acid near the receptor binding site is a clear example of how the virus-driven theft of quantized energy as information is linked from mutations to all pathology in all living genera. That fact can be compared to claims that link the creation of the sun’s anti-entropic virucidal energy from the physiology of pheromone-controlled reproduction to ecological adaptations and all biodiversity.
See: Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system

Genome resequencing revealed a single-nucleotide point mutation in ntrB in strain AR2S, causing an amino acid substitution within the PAS domain of the histidine kinase sensor NtrB [Thr97→Pro97 (T97P)] (13). The fast-spreading strain AR2F had acquired an additional point mutation in the σ54-dependent EBP gene ntrC, which alters an amino acid (R442C) within the DNA binding domain (Table 1 and table S2).

The authors referred to an energy-dependent base pair change and the amino acid substitutionThr97→Pro97 (T97P) as if the substitution resulted from a single-nucleotide point mutation. Next, they claimed an additional point mutation alters an amino acid (R442C) within the DNA binding domain. R442C is an energy-dependent C>T base pair change.
See for an example of deliberate obfuscation: AA mutation p.R442C (Substitution – Missense, position 442, R➞C)
CDS mutation c.1324C>T (Substitution, position 1324, C➞T)
Two energy-dependent changes in base pairs were linked to the pheromone-controlled physiology of reproduction in P. fluorescens, which fluoresces on exposure to UV light. That fact is the clearest experimental evidence that UV light energy was the source of the energy required to link the base pair changes to the amino acid substitution that stabilized the reorganized genome of the organism that resurrected its flagellum over the weekend.
Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism (revisited)

Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH, and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose of the catabolic arms of metabolism and then drive many anabolic pathways. Such analyses largely leave out how and why ATP, NADH, and acetyl-CoA (Figure 1) at the molecular level play such central roles.

Remember, the kinetically stable thermodynamic biocatalytic cascade for optical detection of three amino acids used two detection pathways that linked a measurement of UV light and NADH at 340 nm to the conversion of NADH to a visible color, which was observable at 580 nm. That fact refutes all claims about the evolution of amino acids, the evolution of proteins, and the evolution of any species. The light energy-dependent RNA-mediated amino acid substitutions are biophysically constrained by the physiology of reproduction in species from microbes to humans. The facts of life have now been linked to Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism
In the context of one energy-dependent base pair change and one RNA-mediated amino acid substitution, I linked the ingestion of sago palm-like leaves to the increased level of endogenous vitamin C and cell type stability in a modern human population via the mouse model. One base pair change and one amino acid substitution exemplified how top-down causation and bottom-up effects must be linked from what organisms eat to the physiology of pheromone-controlled reproduction and biophysically constrained viral latency.
Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

Kinetically Stable Thermodynamically Activated Cell Metabolism (5)

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