Kinetically Stable Thermodynamically Activated Cell Metabolism (6)

By: James V. Kohl | Published on: December 25, 2017

Conclusion: Just when you thought eugenics couldn’t get any worse

…it wasn’t the first time humans had assessed other humans using random metrics and criteria thought to be scientific; such practices… would later be employed by the Nazis to determine who lived or died.

When CDC funding docs recommended against random metrics that were used in claims about “science-based and/or ” “evidence-based” et al., the Trump administration was accused of censorship and President Trump was compared to Hitler.
See: Highly Specific Olfactory Receptor Neurons for Types of Amino Acids in the Channel Catfish
See: Molecular Phylogeny Inferred from the Concatenated Genes of Two Neotropical Catfish Species and Implications for Conservation
Olfactory Detectability of L-Amino Acids in the European Honeybee (Apis mellifera)

Across-species comparisons of the detectability of and sensitivity to amino acids suggest that the number of functional genes coding for olfactory receptors may affect both a species’ sensitivity for odorants and the breadth of its spectrum of detectable odorants.

Olfactory perception of 6 amino acids by human subjects

Given that the odors of 4 of the 6 amino acids tested here were detected at concentrations lower than their corresponding taste detection thresholds, this may have important implications for the widespread use of amino acids as food additives as well as for the evaluation of off-flavors caused by amino acids.

…this process was not a straightforward, smooth one – instead, it seems to have been punctuated, with different evolutionary patterns in different geographical regions.
Hemoglobinopathies are the most common single-gene genetic disorders in humans. The disorders are caused by pathogenic genome variants in the human α-like and β-like globin gene clusters. Energy-dependent error-prone RNA-mediated DNA repair links single nucleotide substitutions referred to as indels [INsertions/DELetionS] via amino acid substitutions and hemoglobin variants. The virus-driven degradation of messenger RNA leads to molecular defects in either regulatory or coding regions of the human HBA2, HBA1, HBB or HBD genes. Reduced expression of these genes is linked to α-, β- or δ-thalassemia, respectively.

For comparison, more than 1300 hemoglobin variants attest to the obvious fact that evolutionary theorists cannot recognize any pattern that links food energy from what humans eat to the biophysically constrained pheromone-controlled physiology of reproduction via energy-dependent RNA-mediated amino acid substitutions. The substitutions protect all organized genomes from the virus-driven degradation of messenger RNA. The degradation of messenger RNA links mutations to all pathology.

See for examples of pathology prevention that biologically uniformed pseudoscientists have placed into the context of mutations and natural selection HbVar: A Database of Human Hemoglobin Variants and Thalassemias

Impact of annotation error in α-globin genes on molecular diagnosis

…ethnic specific sequences should be considered as reference sequence for the analysis to bypass sequence dissimilarities among diverse populations.

Ethnic-specific sequence differences can be readily linked to species-specific differences by feedback loops and fixation of one food energy-dependent pheromone-controlled amino acid substitution.
 
Caution is advised for any remaining biologically uninformed theorists.
Now, all intelligent people will learn that the 1925 “Scopes Trial” led to the teaching of pseudoscientific nonsense about neo-Darwinian evolution.
 
In the context of ethnic-specific sequences the link from ecological variation to ecological adaptations in all primates varies by as little as one food energy-dependent biophysically constrained amino acid substitution. If you think you are more adapted that those who share diverse ethnicities, compare your healthy longevity to the Amish population in Berne, Indiana.

Just when you thought eugenics couldn’t get any worse

…it wasn’t the first time humans had assessed other humans using random metrics and criteria thought to be scientific; such practices… would later be employed by the Nazis to determine who lived or died.

When CDC funding docs recommended against random metrics that were used in claims about “science-based and/or ” “evidence-based” et al., the Trump administration was accused of censorship and President Trump was compared to Hitler.

For comparison: A Civic Biology: Presented in Problems (1914) linked the 1925 Scopes Trial in Dayton, TN to Hitler’s eugenics despite publication of the 1925 Pulitzer Prize-winning novel “Arrowsmith.” Sinclair Lewis presciently linked our innate anti-phage defense mechanism to all biologically based biodiversity via what is now known about the pheromone-controlled physiology of reproduction and autophagy.

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