Energy-dependent base editing and correction of mutations (3)
(click to enlarge)
Alzheimer’s is tractable from lactose intolerance to diverticulitis and/or colon cancer, which progresses to Alzheimer’s in some people. Others ecologically adapt via a change in diet or reduction of social stress.From Fertilization to Adult Sexual Behavior (1996)
Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegansโฆ
The alternative splicings of pre-mRNA have since been place into the context of energy-dependent changes in microRNAs (aka pre-mRNAs), which have been linked to differentiation of all cell types in all individuals of all living genera.Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription
In the cytoplasm, small RNAs can control mammalian translation by regulating the stability of mRNA. In the nucleus, small RNAs can also control transcription and splicing. The mechanisms for RNA-mediated nuclear regulation are not understood and remain controversial, hindering the effective application of nuclear RNAi and investigation of its natural regulatory roles.
The tractable changes in organized genomes can be viewed in the context of The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression (2014)link to sperm selection by human ova establishes the role of quantized energy as information in the context of the physiology of reproduction, which protects all species from the virus-driven degradation of messenger RNA.ย
In mammals, this is manifested in links from what offspring ingest to their food energy-dependent pheromone-controlled survival. See for example: MicroRNAs: Milkโs epigenetic regulators
The deficiency of exosomal miRNAs in infant formula, and the persistent uptake of milk miRNAs after the nursing period are both linked from consumption of cowโs milk to epigenetic aberrations that appear to induce adverse long-term effects on human health. It seems likely that Vitamin D fortified cow’s milk does not act as advertised with the popular slogan “Got Milk?”
ADDENDUM:
The adverse effects of microRNAs in milk link the difference between lactase persistence and lactose intolerance. Lactose intolerance is caused by a deficiency of the intestinal enzyme lactase that splits lactose into two smaller sugars, glucose and galactose, and allows lactose to be absorbed from the intestine.
See also: Approximately 65 percent of the human population has a reduced ability to digest lactose after infancy. Lactose intolerance in adulthood is most prevalent in people of East Asian descent, affecting more than 90 percent of adults in some of these communities.
The obvious link from milk ingestion to the food energy-dependent de novo creation of an enzyme that is transiently required to stabilize the organized genomes of human infants should be placed into the context of Richard P. Feyman’s claim about human idiocy.
VIDEO Do Microbes Trigger Alzheimerโs Disease?
In light of continued failures to develop effective drugs, some researchers, such as Harvard neurobiologist Rudolph Tanzi , think itโs high time that more effort and funding go into alternative theories of the disease. โAny hypothesis about Alzheimerโs disease must include amyloid plaques, tangles, inflammationโand, I believe, infection.โ
The virus-driven degradation of messenger RNA has been linked to all pathology in all living genera. The food energy-dependent pheromone-controlled physiology of reproduction has been linked to biophysically constrained viral latency and healthy longevity via transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in species from microbes to humans. The structural diversity of supercoiled DNA is the manifestation of changes in base pairs that link changes in the microRNA/messenger RNA balance from RNA editing to fixation of amino acid substitutions that differentiate all cell types. The virus-driven degradation of messenger RNA prevents differentiation, which is how it is linked from infection to amyloid plaques, tangles and inflammation in all diseases.
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3
0
Amino acid-dependent cell type differentiation
8
0
Silencing genes and serious scientists
3
0
Nutrient-dependent microRNAs control cell types
6
0
MicroRNAs and memory
< 1
0
Viruses and ecologically adapted animals
2
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4
0
Quantum correlations/pseudoscience
3
0
Anti-entropic solar energy
5
0
Correctly modeling biological energy
2
0
Questions about life’s diversity
21
0
UV-light mutations and gene loss (not gain)
5
0
Luis P. Villarreal tells it like it is
3
0
Two types of microRNA are not double agents
2
0
What about birds?
5
0
Implicating microRNAs in cancer
2
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2
0
Let there be anti-entropic light (1)
11
0
An epigenetic trap (the prequel)
5
0
Nutritional epigenetics, exercise, and immune system integrity
4
0
The biologically-based origin of the mammalian placenta (2)
6
0
Are viruses microRNAs? (2)
5
0
Are viruses microRNAs?
3
0
RNA-protein interactions reveal biophysical to ecological landscapes
2
0
From Hydra to humans vs a Lakatosian research program
4
0
Dual genomes: exposing the evolution industry
5
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3
0
More than a bag of chemicals?
2
0
RNA eclipses the importance of DNA to cell type differentiation
4
0
Pharmacogenomics
3
0
From deep time into real time: What evolutionary processes?
10
0
Itโs cell type differention, not cell fate determination (2)
3
0
Are evolutionary theorists 'nob ends'?
5
2
No understanding of biodiversity
2
0
Behavioral ecology: please continue to believe in our fantasies
3
0
Color vision refutes the evolutionary dogma of gene duplication
4
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2
0
Systems biology and memory disorders
3
0
RNA-mediated cell type differentiation and behavior
3
0
Metabolism, fixation, health or neurodegerative disorder
2
0
Genotype, observed phenotype, and distinctly disordered behaviors
3
0
RNA-mediated ecological adaptation is not evolution
2
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4
0
A relatively young branch of science called epigenetics
4
0
Baby talk: More misrepresentations of ecological adaptations
2
0
Comparing divergent model organisms
2
1
Order and disorder: Ecological adaptations not mutations
6
0
microRNAs and species relationships
3
0
Cell-type differentiation
2
0
The wrong picture of our evolution
4
0
96 fixed amino acid substitutions, not 96 genes
6
0
Alternative splicings (very technical)
2
0
Pheromone-controlled thermodynamics and cancer
2
0
Alzheimer's, microRNAs, and olfaction
< 1
0
Pheromones and cancer
4
0
Sex differences in Alzheimer's and everything else
2
0
Diet epigenetically effects development of the primate brain
< 1
0
The Epigenetics of Drug Development and Cholesterol Levels
< 1
0
Bee research, human sweet perception, human pheromones, and metabolic disorders
< 1
0
Epigenetics of food odors, nutrition, and pheromones
< 1
0
(click to enlarge)