Kinetically Stable Thermodynamically Activated Cell Metabolism (7)
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Summary: Why is anyone enrolled in a Ph.D program at CU Boulder’s Environmental Studies Program not aware of the facts of life presented in Schrodinger’s “What is Life? (1944) and during a virtual conference on Precision Medicine as Energy as information and constrained endogenous RNA interference Aridity weakens population-level effects of multiple species interactions on Hibiscus meyeri A classic Darwinian ecological hypothesis holds up—with a twist December 25, 2017
Darwin and others have said that what drives this pattern is gradients in density or diversity of interacting species, but instead it seems to be effects of stress on growth, survival, reproduction and germination of the plant species,” said Allison Louthan, who led the research while completing her PhD dissertation in CU Boulder’s Environmental Studies Program.
Darwin’s “conditions of life” were the basis for his claims, which were bastardized by theorists who place natural selection first. Aridity links ecological variation from thermodynamic cycles of protein biosynthesis and degradation from conditions of life to ecological adaptations via energy-dependent fixation of RNA-mediated amino acid substitutions in all living genera. Nutrient stress and or social stress link the proliferation of viruses to all pathology.CU Boulder’s Environmental Studies Program not aware of the facts of life and the virus-driven degradation of proteins presented in Schrodinger’s “What is Life? (1944) and during a virtual conference on Precision Medicine as Energy as information and constrained endogenous RNA interference
Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection. This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid
See also: Virus-mediated archaeal hecatomb in the deep seafloor and Modern diversification of the amino acid repertoire driven by oxygen. New Research Sheds Light on What Inputs Cells Need to Proliferate How Odors are turned into Long-Term Memories December 25, 2017
Neuroscientists Dr Christina Strauch and Prof Dr Denise Manahan-Vaughan from the Ruhr-Universität Bochum have investigated which brain area is responsible for storing odours as long-term memories.
See also: Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment co-authored by Denise Manahan-Vaughan and reported as:Antiviral protein linked to depressed mood in mice April 19, 2016
…the study suggests that the CXCL10/CXCR3 signaling pathway acts as a bridge between rising interferon levels in the blood and changes in neuronal activity in the brain, explaining how virus infection or type I interferon treatment causes mood changes.
The virus-driven degradation of messenger RNA links the theft of quantized energy to all pathology via changes in the microRNA/messenger RNA balance. See for details: microRNA Spatial Olfactory Learning Contributes to Place Field Formation in the Hippocampus co-authored by Denise Manahan-Vaughan
In conclusion, our results suggest that olfactory information is processed in a similar way as visual information regarding place field formation in the CA1 region. These data support that olfactory information can help to stabilize place fields when other sensory modalities are not salient enough.
Pheromones biophysically constrain viral latency, which is how food odors are linked from the creation of enzymes to all biodiversity via the physiology of reproduction. Feedback loops link odor and pheromone signaling with reproduction Proteins in shark teeth could hint at what they eat December 18, 2017
Amino acids are the building blocks of proteins. Scientists can determine where sharks fit into the food web by measuring ratios of different types of nitrogen atoms in amino acids in shark muscle tissue. Certain amino acids accumulate in predictable amounts as they travel up the food chain. But using soft tissue like muscle to analyze a shark’s diet can be tricky, because researchers must collect and store the tissue properly.
But researchers from the University of Southern Florida have found that shark teeth can provide the same feeding information…
If you are one of the biologically uninformed researchers who has, until now, failed to link food energy-dependent changes from atoms to ecosystems in all living genera via the pheromone-controlled physiology of reproduction, please consider a career choice as a pseudoscientist. Alternatively, see: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism
The reliance of the homologation chemistry on hydrogen cyanide (11) (all the carbon and nitrogen atoms in the compounds of the reaction network derive from this single source) and hydrogen sulfide (12) prompts us to use the term ‘cyanosulfidic’ to describe this protometabolic38 systems chemistry.
No experimental evidence of biophysically constrained viral latency suggests that energy emerged or that any species evolved into another species via mutations and natural selection. Whatever it is that skeptics believe in should not be compared to facts about energy-dependent life on Earth or the Afterlife. Indeed, the 2nd Law of Thermodynamics was recently reported to be missing information because theorists assumed the absence of correlated subatomic particles.Reversing the thermodynamic arrow of time using quantum correlations Why Skepticism Is the Right Approach to the Afterlife, Immortality, and Utopia | Michael Shermer
American public intellectual Michael Shermer says that any idea of the afterlife makes zero sense: your mind and therefore your memories are beholden to your body and that any version of you that made it into heaven, should there actually be one, would just be a copy of you and unable to register that they were actually in heaven.
All public intellectuals should declare their conflicts of interest and/or admit they are not scientists before admitting the best they are good for is ridicule. Shermer, for example, claims there is no sense of progress outside the context of culture.VIDEO
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2
0
Masters of deception about nature (2)
7
0
The Mind’s Eyes (revisited)
10
0
Modelling life scientifically: RNA-mediated events
12
0
Energy-dependent RNA methylation (8)
4
0
Energy-dependent RNA methylation (6)
9
0
Energy-dependent RNA methylation (3)
10
0
Energy-dependent RNA methylation (2)
5
0
Energy-dependent biodiversity (4)
4
0
Energy-dependent biodiversity
5
0
Countdown to Genetics and Genomics
< 1
0
Energy-dependent creation and entropy
4
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5
0
Molecular Diagnostics: What is unprotected life? (5)
5
0
Molecular Diagnostics: What is unprotected life?
2
0
Ricki Lewis’ Time Machine (4)
8
0
Creating nutrient-dependent life with enough genes to survive
3
0
Confusing effects and affects of visual input
2
0
Selective reporting of inferences: examples of pseudoscience
14
0
Ignore the evidence: Rachel Feltman
5
0
Energy-dependent purpose vs teleophobic telorexia
12
0
Stress-linked population-level history dependence
5
0
Jay R. Feierman: twenty years of antagonism
5
0
Energy dependent RNA-mediated immunity (3)
8
0
Energy dependent RNA-mediated immunity (2)
10
0
Energy-dependent RNA-mediated immunity (1)
10
0
RNA-mediated DNA modifications
5
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3
0
Hybrids: making microbes and Democrats into monkey’s uncles?
11
0
Hydrogen-atom transfer in DNA base pairs (7)
5
0
Bacteria see the light and they adapt
7
0
Will modern human populations adapt to the Zika virus?
5
0
Models of scientific literacy
3
0
Cancer: Evolution 2.0’s Blind Spot
13
0
Hydrogen-atom transfer in DNA base pairs (5)
10
0
Blood test links atoms to ecosystems
2
0
Juvenile hormone links atoms to ecosystems
3
0
Teleophobes vs teleophiles: a recent history
2
0
Genes, orchid odors, and pheromones from blonds
5
0
Amino acid substitutions, stress, and human behavior
3
0
MicroRNA-mediated RNA epigenetics
2
0
Finding peace and π in the light of H bond energy
5
0
Epigenetic (re)programming of behavior
4
0
NORAD: air defense and defense against genomic entropy
7
0
Manufacturing fossil “evidence”
4
0
RNA-mediated theory killers (3)
7
0
RNA-mediated regulatory mechanisms link microbes to humans (3)
5
0
Essential pseudoscientific concepts of atheism
3
0
RNA-mediated theory killers
6
0
Natural cooperation and Evolution 2.0
6
0
A two-faced protein enables RNA-mediated DNA repair (5)
4
0
Neo-Darwinism vs the neocortex
4
0
A two-faced protein enables RNA-mediated DNA repair
2
0
Nutrient-dependent trophic analogs
3
0
Plasma created by sunlight and RNA–mediated epigenetic heredity
2
0
Stress-perturbed mitochondrial dysfunction (2)
5
0
Theorists can’t understand biology
6
0
Sensationalizing no new mechanism
2
0
Fossils vs cell types and the brain
3
0
Cyclic cosmology and the stability of organized genomes
4
0
RNA central and RNA-mediated.com
6
0
The virome, microbiome, replisome and supercoiled DNA
2
0
Skip the politics; embrace the facts
5
0
Controled Stem Cell Expansion
3
0
Human pheromone deniers: What’s next?
5
0
Mystery machine vs model (2)
2
0
Preventing genomic entropy
4
0
Energy and evolution: another opinion?
2
0
Supercoiled DNA constrains virus-driven genomic entropy
2
0
Let there be anti-entropic light (2)
4
0
Microbes to humans 2015 Nobel Prize
2
0
Mechanisms of stress: from genes to cancer
9
0
Viruses come alive: Tree of life pseudoscience
6
0
Hijacked light energy and vertebrate pathology
4
0
Theorists have not seen the light
4
0
A Darwinian pediatrician and expected life span
2
0
A 5-10K comparison of design principles to evolution
3
0
Alternative pre-mRNA splicing and ecological adaptation
7
0
Exosomes and the RNA-mediated future of medicine (3)
2
0
Exosomes and the RNA-mediated future of medicine
5
0
Multi-omic analysis features (SNPs, miRNA)
3
0
Natural selection: an anti-entropic force?
2
0
Genome sequencing, cadherins, and quantum consciousness
6
0
“New” quantum biology. Pirating the old
3
0
Cell types, SNVs, CNVs, and chromosomes
3
0
A “new” code enables ecological adaptation
4
0
Anti-entropic containment of energy: symbiosis 1.0
5
0
The “great filter” is an epigenetic trap
4
0
Information and communication (2)
6
0
Olfaction & the octopus and human genomes (2)
4
0
Ecology replaces the extended evolutionary synthesis
4
0
The stability of organized genomes (3)
3
0
Viruses, amino acids, and somatic cell types (3)
9
0
Viruses, amino acids, and somatic cell types (2)
5
0
Viruses, amino acids, and somatic cell types
4
0
Hematopoiesis and practopoiesis
4
0
Koonin: viruses killed neo-Darwinism
3
0
Becoming biologically informed (3)
3
0
Easy editing: Reinventing our RNA world
3
0
Riding the wrong direction
3
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6
0
MicroRNA controlled growth and brain development
7
0
MicroRNA – controlled ecological adaptations
5
0
“New” epigenetic mechanism for lifelong learning?
3
0
Protein folding and Google page rank
2
0
Iron, ferritin, thyroxine
2
0
Nutrient stress-induced RNA-mediated pathology
< 1
0
Theoretically, purifying selection is evolution
< 1
0
RNA-mediated development
2
0
Creating and maintaining the human virome
2
0
Ignoring top-down causation
2
0
microRNAs, glycosylation, and genomes
4
0
Alternative splicings: epigenetics meets pharmacogenomics
4
0
Epigenetic regulation of aging by glycine and GnRH
5
0
Pattern recognition: biogeochemical structure and function
5
0
Informing the biologically uninformed
< 1
0
I forgot. How do mutations cause evolution?
4
0
Batch effect vs epigenetic effects
3
0
Gene expression, immortality, and cancer
6
0
Scientists lose. A sci-fi author gains credibility
2
0
Vitamin B3 and DNA repair
4
0
Ignoring systems complexity (it’s too complicated)
3
0
Five years of Ferguson
2
0
Computing via phosphorylation and fixation
3
0
Virus-driven cancer treatment and prevention
2
0
A special issue on nutritional epigenetics
5
0
Retinoic acid + one receptor regulate the genome
3
0
Epigenetics: microRNAs effect an integrative pathway
4
0
Protein isoforms do not evolve
3
0
From gut bacteria to breast milk and back
5
0
How to find a “holy grail” under your nose
3
0
Physics, chemistry, light, and life
2
0
MicroRNAs and the exposome
5
0
Thermodynamics and protein folding landscapes
2
0
RNA-mediated silencing of a chromosome
3
0
Feedback loops link insects to human brains
2
0
DNA Methylation and organized genomes (2)
10
0
Misunderstanding cancer
7
0
Amino acid-dependent cell type differentiation
8
0
Mutisensory integration: watching the paradigm shift
12
0
Origin of life and cancer (1,2,3)
2
0
Silencing genes and serious scientists
3
0
The miRNA/mRNA balance: a suboptimal strategy?
2
0
Nutrient-dependent microRNAs control cell types
6
0
Too many targets for theories
3
0
Methylation maintains cell type differences
3
0
Creating nothing but a theory
4
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4
0
Quantum correlations/pseudoscience
3
0
Anti-entropic solar energy
5
0
Questions about life’s diversity
21
0
Luis P. Villarreal tells it like it is
3
0
RNA-directed gene choice
5
0
Two types of microRNA are not double agents
2
0
Epigenetics Skeptism
5
0
Is DNA-directed transcription RNA-mediated?
2
0
What about birds?
5
0
Implicating microRNAs in cancer
2
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2
0
Reverse phosphorylation
7
0
RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3
0
RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3
0
From 3-D to epigenetically-effected 4-D genome make-up
5
0
Let there be anti-entropic light (1)
11
0
An epigenetic trap (the prequel)
5
0
Atheism: Arrogant, useless, and divisive ignorance
7
0
Nutritional epigenetics, exercise, and immune system integrity
4
0
What if Darwin was not still dead?
2
0
How fast can evolutionary theory be changed?
5
0
Biological energy and a microbiome model of a light-driven time machine
3
0
Mute points: most are afraid to mention them
6
0
All of "like kind" in the (bigger) family
6
1
Environment epigenetically shapes the immune system
3
0
Beneficial microbes kill beneficial mutations
4
0
Constrained evolution is ecological adaptation
5
0
A single amino acid substitution differentiates cell types of E. coli
3
0
Unconstrained evolutionary innovability
4
0
Mutagenesis: Replacing facts with theories
5
0
From Hydra to humans vs a Lakatosian research program
4
0
Unified nutritional and molecular mechanisms
9
0
Removing natural selection; reshaping the horse; adjusting evolutionary theory
4
0
Models by evolutionary biologists are not models
2
0
The future of physics predicts no future for evolutionary theory
3
0
Chemical ecology and RNA-mediated control of DNA loops
< 1
0
Jumping back: Science or Pseudoscience? (2)
2
0
Jumping back: Science or Pseudoscience?
6
0
Extensive molecular evidence vs ridiculous theories
2
0
Dual genomes: exposing the evolution industry
5
0
Meaningful dialogue, anonymous fools and idiot minions
4
0
Sackler Colloquium: Effects or AFFECTS on Behavior
2
0
Thermodynamic constraints and ecological adaptations sans evolution
6
0
Ecological adaptations reported as evolution in insects and mammals
4
0
SNPs and millions of small variations in the human genome
3
0
Achiral GnRH: no prophesy, just prediction
9
0
Making sense of quotes scattered across disciplines
2
0
We need pattern recognition, not proclamations
3
0
We need pattern recognition, not a prologue
6
0
Sexual differentiation of cell types in plants
2
0
From deep time into real time: What evolutionary processes?
10
0
In theory, or supported by experimental evidence?
5
0
Evolutionary theorists justify fear of the Ebola viruses
2
0
No understanding of biodiversity
2
0
Behavioral ecology: please continue to believe in our fantasies
3
0
2014 and 2004 Nobel Prize in Medicine
3
0
RNA-mediated genetic engineering (Part 3)
< 1
0
RNA-mediated genetic engineering (Part 2)
3
0
RNA-mediated genetic engineering
2
0
Forces of "Nature" limit dissemination of information
4
0
Metabolism, fixation, health or neurodegerative disorder
2
0
Physics, Chemistry, and Molecular biology (PCMb)
2
0
RNA-directed DNA methylation and RNA-mediated events
5
1
Seemingly futile cycles are not thermodynamically futile
3
0
A molecular visualizer of worthwhile molecular biology
2
0
RNA-mediated events found everywhere
2
0
Insect homology and diversity attributed to mutations
2
0
The quantum biology of consciousness
3
0
Genes and Race: Human History?
2
0
Cell-type differentiation
2
0
Darwinian theories vs Darwin's facts
2
0
Don't tell the Creationists
2
0
Nutrient-dependent pheromone-controlled stickleback evolution
2
0
Evolution: innovations may have non-adaptive origins (sans mutations)
2
0
Pheromones and cancer
4
0
Evolutionarily innovative DNA mistakes?
< 1
0
Natural selection: New insights are unlikely
< 1
0
Human pheromones and the definition of life
2
0
Adam’s rib: Pheromones and the adaptive evolution of human sexuality
2
0
Did viruses make mammals communicate with pheromones?
2
0
Epigenetics and the connectome
2
0
(click to enlarge)