Diet-driven RNA interference and cancer prevention (4)
(click to enlarge)
Excerpt: What I perceive as apathy can be attributed to the lack of empathy for anyone who suffers from the preventable or controlled virus-driven pathology that, sooner or later, kills us all.
In the case of our Vietnam veterans, naturally occurring prevention or effective treatment of glioblastoma might be achieved by dietary intervention with a curcumin supplement.
“micrornas”[MeSH Terms] OR “micrornas”[All Fields] OR “microrna”[All Fields] Items: 1 to 20 of 68871
See: The tipping point (revisited): 68,000 publications
69,000 published works on microRNAs will be the next “tipping point.” Predictably, it will be reached during the same 28 day period in which my tweets (@jvkohl have received more than 70,000 impressions.
On 1/18/18: Tweet impressions 71.2K 602.0%
The 602.0% increase has not been accompanied by a significant increase in followers or a significant increase in engagements.
What I perceive as apathy can be attributed to the lack of empathy for anyone who suffers from the preventable or controlled virus-driven pathology that, sooner or later, kills us all.
In the case of our Vietnam veterans, naturally occurring prevention or effective treatment of glioblastoma might be achieved by dietary intervention with a curcumin supplement.
See: A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model
DP-Cur is an efficient carrier of miR21ASO and the combined delivery of miR21ASO and curcumin may be useful in the development of combination therapy for glioblastoma.
See also: Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
This is the first study, to our knowledge, to demonstrate the utility of a pharmacological inhibitor of glutamine transport in oncology, representing a new class of targeted therapy and laying a framework for paradigm-shifting therapies targeting cancer cell metabolism.
Reported as: Researchers find a way to ‘starve’ cancer
Glutamine is an essential amino acid for many cell functions including biosynthesis, cell signaling and protection against oxidative damage. Because cancer cells divide more rapidly than do normal cells, they need more glutamine.
A protein called ACST2 is the primary transporter of glutamine into cancer cells. Elevated ASCT2 levels have been linked to poor survival in many human cancers, including those of the lung, breast and colon. Genetic studies that silence the ACST2 gene in cancer cells have produced dramatic anti-tumor effects.
See also: MicroRNA[s] and glutamine Items: 1 to 20 of 65
The facts about food energy-dependent microRNA-mediated RNA-directed DNA methylation and fixation of RNA-mediated amino acid substitutions that differentiate all cell types in all individuals of all living genera were removed from this report. Use off the cryo-EM technology links energy-dependent changes in electrons to healthy longevity in all ecosystems. It is apparent that some researchers do not want more people to learn about that fact.
See: Structural basis of RNA polymerase III transcription initiation
The unwound DNA directly contacts both sides of the Pol III cleft. Topologically, the Pol III PIC resembles the Pol II PIC, whereas the Pol I PIC is more divergent. The structures presented unravel the molecular mechanisms underlying the first steps of Pol III transcription and also the general conserved mechanisms of gene transcription initiation.
The information that links the virus-driven theft of quantized energy from the negative supercoiling (unwinding) of supercoiled DNA was removed in this attempt to support the neo-Darwinian pseudoscientific nonsense about the three domains of life. The bastardization of the use of cryo-EM technology occurred in the following context(s).
1) There is no mention of the quantized anti-entropic virucidal energy as information that is required to create ATP and RNA.
2) The energy-dependent creation of ATP and the creation of RNA is not linked to healthy longevity in all living genera via the physiology of pheromone-controlled reproduction.
3) The fixation of RNA-mediated amino acid substitutions that stabilize the differentiated cell types of all living genera are viewed in the context of negative supercoiling that occurs in an ATP-independent manner.
4) A spontaneously formed transcription bubble links the energy-dependent stability of supercoiled DNA to cell type differentiation in species from bacteria to humans.
5) The claim that promoters can be opened without ATP hydrolysis is used to suggest that no energy-dependent supercoiling is required to link the three kingdoms of life — assuming that there are three kingdoms of life.
6) The fact that the virus-driven degradation of messenger RNA in humans causes them to become non-human primates and the fact that it also cause bacteria to archaea and L-forms is ignored.
See: Virus-mediated archaeal hecatomb in the deep seafloor
We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.
By deliberately removing virus-archaea interactions from the representations reported as: Scientists zoom in to watch DNA code being read, pseudoscientists have reverted to promotion of their ridiculous gene-centric theories.
See for comparison: “Cytosis”
A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!
See also: Attacked from All Sides: RNA Decay in Antiviral Defense
…RNA decay machinery plays important roles in antiviral defense. This can involve either direct effects on vRNA stability or indirect regulation of the intracellular milieu. Furthermore, an emerging theme suggests that many RNA binding proteins can be repurposed from their endogenous roles in the nucleus to antiviral roles in the cytoplasm. Future studies are necessary to further elucidate how these RNA binding proteins recognize foreign RNAs and how they interface with the RNA decay machinery to restrict vRNA replication.
Accurate representations of how natural selection for food energy-dependent codon optimality links the physiology of pheromone-controlled reproduction to the transgenerational epigenetic inheritance of healthy longevity will continue to be attacked from all sides.
Biologically uninformed theorists and philosophers can do nothing else but attack after proclaiming the nonsense of mutation-driven evolution during the past decades. They have failed to link their nonsense to the prevention of all pathology or to effective treatments via optimization of autophagy: the innate antiphage defense mechanism of all living genera.
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0
Tasting light links energy from creation to adaptation
9 MIN READ
0
Politicized science: The demise of RNA-mediated.com?
3 MIN READ
0
The futility of The Battlefield FB group
10 MIN READ
0
Metabolic Phenotyping Research
2 MIN READ
0
Phylogenetic similarity sans energy
2 MIN READ
0
De novo gene creation: Ignoring the experimental evidence
7 MIN READ
0
Energy-dependent coulombic, autophagic, polycombic healthy longevity
4 MIN READ
0
Light, behavior and autophagy, a gender-specific risk factor
4 MIN READ
0
Energy-dependent purifying selection / autophagy (2)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (3)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (4)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (5)
2 MIN READ
0
Energy-dependent purifying selection / autophagy
2 MIN READ
0
Optogenetics: Let there be virucidal light!
2 MIN READ
0
Theorists struggle with the concept of autophagy
2 MIN READ
0
Base pairs, amino acids and phenotypes
10 MIN READ
0
Survivors of RNA-mediated terrorism
5 MIN READ
0
Building delicious base pairs in class. It’s elementary Watson and Crick
3 MIN READ
0
Building delicious base pairs in class. It's elementary Watson and Crick
3 MIN READ
0
RNA-mediated “repurposing” is autophagy
2 MIN READ
0
RNA-mediated "repurposing" is autophagy
2 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (8)
4 MIN READ
0
Epigenetically effected energy-dependent fluorescence (2)
6 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (7)
3 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (4)
< 1 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (3)
< 1 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (2)
2 MIN READ
0
From Precis to Proof in 6000 years (2)
5 MIN READ
0
From Precis to Proof in 6000 years
9 MIN READ
0
Polycombic ecological adaptation as a science, not a theory (2)
12 MIN READ
0
Polycombic ecological adaptation as a science, not a theory
3 MIN READ
0
80 years of causal analysis (1936 – 2016)
11 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
Pheromone-controlled autophagy
4 MIN READ
0
Hecatombic evolution via oncocers and oncohistones
9 MIN READ
0
Did evolution autophosphorylate your kinases? (2)
5 MIN READ
1
Did evolution autophosphorylate your kinases?
5 MIN READ
1
Nutrient-dependent autophagy
3 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy (2)
6 MIN READ
0
The last RNA-mediated theory killer (2)
7 MIN READ
0
Asking the right questions (2)
3 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy
3 MIN READ
0
Life is energy-dependent task management
3 MIN READ
0
Hypothesis free pseudoscience vs facts (5)
6 MIN READ
0
Hypothesis free pseudoscience vs facts (4)
5 MIN READ
0
Antithetical conclusions (4)
3 MIN READ
0
The Origin of Information (2)
6 MIN READ
0
The tipping point? 50,000 publications (5)
3 MIN READ
0
Did “Nature” kill Steve Jobs? (3)
10 MIN READ
0
Did “Nature” kill Steve Jobs? (2)
6 MIN READ
0
Major transition ends use of silly theories
5 MIN READ
0
Energy-dependent RNA methylation (8)
4 MIN READ
0
The tipping point? 50,000 publications (3)
6 MIN READ
0
Selective reporting of inferences: examples of pseudoscience
14 MIN READ
0
The Light and Darkness of “Evolution 2.0”
11 MIN READ
0
Origin and evolution of the genetic code
2 MIN READ
0
Center stage RNA-mediated events (since 1996)
3 MIN READ
0
Did Brain Atrophy Evolve?
2 MIN READ
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
RNA-mediated theory killers
6 MIN READ
0
Sulfated steroids and RNA-mediated identity codes
< 1 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Virucidal effects on ecological speciation
5 MIN READ
0
Unconscious affect (revisited)
2 MIN READ
0
Living the life that randomness created? (Sarcasm alert)
3 MIN READ
0
Appetite for ingesting theories (raw)
< 1 MIN READ
0
A lighting requirement for life
11 MIN READ
3
Bees and primates automagically evolve
3 MIN READ
0
Targeting theories to fight disease
2 MIN READ
0
Computing via phosphorylation and fixation
3 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Behavior (4): All responses are RNA-mediated in birds
4 MIN READ
0
Assembling yourself: Molecular self / other recognition
4 MIN READ
0
Reverse phosphorylation
7 MIN READ
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2 MIN READ
0
RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3 MIN READ
0
RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3 MIN READ
0
An epigenetic trap (the prequel)
5 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
0
Glycine and GnRH: Am I being pedantic?
4 MIN READ
0
The key to science: experimental evidence
5 MIN READ
0
A model of MHC 'evolution'
2 MIN READ
0
ALPHA GENOMIX
7 MIN READ
2
Systems biology and memory disorders
3 MIN READ
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4 MIN READ
0
Biophysically constrained beginnings of RNA and DNA
4 MIN READ
0
Don't tell the Creationists
2 MIN READ
0
Targeting a cancer gene
2 MIN READ
0
Music to our ears and song in birds: a common sense approach
2 MIN READ
0
Human Pheromones: Diversity of signaling pathways and a common response (Part 2)
2 MIN READ
0
Human Pheromones in Socioaffective Neuroscience & Psychology
2 MIN READ
0
The “yuck” factor: aversion to social odors?
2 MIN READ
0
Study results: Human pheromones affect women’s behavior
< 1 MIN READ
0
The great pheromone myth revisited (including biological factors in the development of sexuality)
4 MIN READ
0
The great pheromone myth revisited (including biological factors in the development of sexuality)
4 MIN READ
0
Wikipedia comments by James V. Kohl
5 MIN READ
0
Genes, Hormones, and Behavior (for other scientists)
4 MIN READ
0
Tears and fears of pheromones
2 MIN READ
0
Product comparisons and human pheromone sciences
3 MIN READ
0
Conditioned sexual arousal to odor
2 MIN READ
0
Pheromones of pregnant women effect prolactin in men
< 1 MIN READ
0
The Great Pheromone Myth (opinion/review)
19 MIN READ
0
Luteinizing hormone, sex, and smell (18 years later)
2 MIN READ
0
