Diet-driven RNA interference and mental health (1)

By: James V. Kohl | Published on: January 19, 2018

The historical record of facts about the transgenerational epigenetic inheritance of RNA-mediated diet-driven mental health must be viewed in the context of the claims made by neo-Darwinian theorists and “Big Bang” cosmologists. They refused to link the creation of the anti-entropic virucidal energy of sunlight on contact with water from the creation of microRNAs to all biodiversity on Earth via the creation of enzymes. They still refuse to acknowledge the fact that the physiology of pheromone-controlled reproduction in species from microbes to humans biophysically constrains viral latency in the context of food energy-dependent metabolism.

See: Cytosis: A Cell Biology Board Game

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

Energy is required to build enzymes, hormones and receptors in the context of the inheritance of all microRNA-mediated development of enzyme-dependent morpholgoical and behavioral phenotypes. The energy must be linked from the creation of enzymes to what is known about epigenetic imprinting. That is the only way to avoid linking the emergence of the energy to ridiculous neo-Darwinian theories of evolution. The theories are ridiculous because they do not start with the creation of energy, which must be linked to the creation of life.
For instance, Darwin started with “conditions of life” and he linked them from the energy-dependent physiology of reproduction to all biodiversity on Earth.
We did that in this Hormones and Behavior review: From Fertilization to Adult Sexual Behavior (1996)

Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

A potential ramification of epigenetic imprinting and alternative splicing may be occurring in Xq28, a chromosomal region implicated in homosexual orientation (Brook, 1993; Hu, Pattatucci, Patterson, Li, Fulker, Cherny, Kruglyak, and Hamer, 1995; Turner, 1995). Xq28 contains one of the X chromosome’s two pseudoautosomal regions (PARs), adjoins the telomere, and has various means of gene expression control (D’Esposito, Ciccodicola, Gianfrancesco, Esposito, Flagiello, Mazzarella, Schiessinger, and D’Urso (1996). Xq28, therefore, is a chromosomal region that has many of the heterochromatic and telomeric characteristics that participate in sexual determination and behavior in other species.

Had there been no support for the claims we made about energy-dependent RNA-mediated epigenetic imprinting, it would not be such an embarrassment to the pseudoscientists who ignored our claims. But soon, our claims led to more refutations of neo-Darwinian nonsense.
See: Feedback loops link odor and pheromone signaling with reproduction
See also: Non‐coding RNAs as the bridge between epigenetic mechanisms, lineages and domains of life (2014)

Regulatory RNA exchange between different organisms could be an important component in the hologenome’s genetics, since RNA is a ‘universal language’ which affects other epigenetic processes, and in certain cases can become heritable.

But wait, what about humans? Transgenerational Epigenetic Inheritance: Myths and Mechanisms (2014)

Although the inheritance of epigenetic characters can certainly occur—particularly in plants—how much is due to the environment and the extent to which it happens in humans remain unclear.

Reported as: End the Hype over Epigenetics & Lamarckian Evolution

…epigenetic inheritance has been demonstrated in plants and worms. But, mammals are completely different beasts, so to speak. Mammals go through two rounds of epigenetic “reprogramming” — once after fertilization and again during the formation of gametes (sex cells) — in which most of the chemical tags are wiped clean. be very skeptical of studies which claim to have detected health effects due to epigenetic inheritance. The hype may soon fade, and the concept of Lamarckian evolution may once again return to the grave.

But wait, what about the hype? RNA interference is essential for cellular quiescence (2016)

Quiescent cells play a predominant role in most organisms. Here, we identify RNA interference (RNAi) as a major requirement for quiescence (G0) in Schizosaccharomyces pombe. RNAi mutants lose viability at G0-entry and are unable to maintain long-term quiescence. We obtained dcr1Δ G0 suppressors, which mapped to genes involved in chromosome segregation, RNA polymerase-associated factors, and heterochromatin formation. We propose a model in which RNAi promotes RNA polymerase release in cycling and quiescent cells: (i) RNA pol II release mediates heterochromatin formation at centromeres allowing proper chromosome segregation during mitotic growth and G0-entry, and (ii) RNA pol I release prevents heterochromatin formation at rDNA during quiescence maintenance. Our model may account for the co-dependency of RNAi and H3K9 methylation throughout eukaryotic evolution.

How could RNA interference be essential for cellular quiescence in the context of the co-dependency of RNAi and H3K9 methylation throughout eukaryotic evolution if the co-dependency occured only in the context of biophysically constrained viral latency?

For comparison see:

Moving forward, see: Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis (2018)

We show that these epigenetically activated small interfering RNAs (easiRNAs) mediate hybridization barriers between diploid seed parents and tetraploid pollen parents (the ‘triploid block’), and that natural variation for miR845 may account for ‘endosperm balance’ allowing the formation of triploid seeds.

What molecular mechanisms might link natural variation for miR845 to the mediation of hybridizations between diploid seed parents and tetraploid pollen parents? The suggestion is clear!

Epigenetically activated small interfering RNAs (easiRNAs) must link ecological variation / natural variation to ecological adaptation in the context of biophysically constrained viral latency and the epigenetically altered behavior of species from microbes to humans. Who wants to pretend that the conserved molecular mechanisms of microRNA-mediated transgenerational epigenetc inheritance do not extend from the energy-dependent creation of microRNAs in plants to differences in human behavior?

See: Hydrolysis by Catalytic IgGs of microRNA Specific for Patients with Schizophrenia

…revealed site-specific hydrolysis of four known SCZ specific microRNAs (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p) playing an important role in the regulation of several genes functioning. Three major of cleavage sites are located in the microRNA loops or duplex parts directly articulated with the loops. RNase abzymes can contribute to decreasing of microRNAs effects on the functioning of numerous genes and the products of their transcription. Therefore, abzymes with RNase activity may be to some extent important for the development of schizophrenia.

See for comparison: [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)]

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

It has been clear to most serious scientists that food odors and pheromones biophysically constrain viral latency, which is how they link biologically-based cause and effect from energy-dependent changes in microRNAs. The energy-dependent changes in microRNAs typically link ecological variation to ecological adaptions. That level of clarity must be placed into the context of preventative medicine and the effective treatment of all virus-driven pathology.

See: Diet-driven RNA interference and mental health (2)

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