The tipping point (revisted): 69,000 publications

By: James V. Kohl | Published on: January 20, 2018

See first: The tipping point (revisited): 68,000 publications December 21, 2017
On December 24, 2017, I started a “tweet” series on Twitter, which was designed to test the response to accurate information about RNA-mediated energy-dependent biophysically constrained viral latency. Nearly 80,000 impressions have led to few engagements and virtually no discussion during a time when almost 1000 additional published works have been indexed on the PubMed database.
In my January 20, 2018 PubMed search for term “microRNA,” among nearly 69,000 results, I found:
Small RNA pathways responsible for non-cell-autonomous regulation of plant reproduction

…the non-cell-autonomous regulation by somatic companions plays important roles in efficient reproduction, in addition to the cell-autonomous regulation. Epigenetic silencing of transposable elements is one of the central events by which the germline transmits the error-free genome to the next generation.

Non-cell-autonomous microRNA-mediated regulation of plant reproductive physiology links the physiology of pheromone-controlled reproduction in soil bacteria to the creation of selenocysteine via the anti-entropic virucidal energy of sunlight.
Today’s blog post target audience is the biologically uninformed science journalists who refuse to ask or to answer questions about mutations and evolution, especially when the questions are placed into the context of what is known to all serious scientists about The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression.
See: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression. What is known to serious scientists link Schrodinger’s claims about sunlight from negentropy (aka the anti-entropic virucidal effects of UV light) to the creation of soil bacteria, bull dung (aka BS), and back to all biophysically constrained viral latency and biodiversity.
Without the energy-dependent creation of microRNAs and enzymes I do not believe that the vertebrate-like metabolism of food to pheromones in insects and elephants could be linked from fescue toxicosis, BS, and the bull sperm microRNAome to healthy longevity or to all virus-driven pathology.
Insect pheromone in elephants (1996)

SIR – (Z)-7-dodecen-l-yl acetate is used by the females of more than 126 species of insects, especially Lepidoptera, as part of their pheromone blends to attract insect males1. Female Asian elephants, Elephas maximus, also use a pheromone to signal to males their readiness to mate2.

See also:


Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.

I think that Facile Recoding of Selenocysteine in Nature  should be considered by intelligent science journalists to be an example of how energy-dependent biophysically constrained viral latency must be linked from the creation of microRNAs to all biodiversity.
Ridiculous claims of cell-autonomous regulation of the functional structure of supercoiled DNA should be replaced by what is known about the light-activated endogenous substrates, which also are required for the biogenic creation of uranium ores.
Claims that the light-activated creation of ATP, RNA, and all energy-dependent biophysically constrained biodiversity can now be viewed in the context of published works make biologically uninformed science journalists appear to be the purveyors of pseudoscientific nonsense touted by neo-Darwinian theorists.
See for comparison:  Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See also: Cytosis

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

The science behind the game Cytosis and the science behind the claims of energy-dependent creation of all biophysically constrained biodiversity can now be learned by playing a cell biology game for anyone 10 years old or older. That probably includes most so-called science journalists. They can now learn enough about cell biology from a game to inform their target audience.
However, that’s probably not going to happen. Here’s why:

“A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it.” — Max Planck

See also: Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull
Most science journalists have been trapped by pseudoscientists who have taught the journalists to believe that cutting edge research supported claims about neo-Darwinian evolution. They have been trapped in examples of human idiocy,


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