Autophagy in health and disease (1)
(click to enlarge)
Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors
Each of these pathways have an intimate relationship with the programmed death pathways of autophagy and apoptosis and share a common link to the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) and the mechanistic target of rapamycin (mTOR). Circadian clock genes are necessary to modulate autophagy, limit cognitive loss, and prevent neuronal injury. Non-coding RNAs can control neuronal stem cell development and neuronal differentiation and offer protection against vascular disease…
The author includes what is known about the links from biophysically constrained RNA-mediated energy-dependent pheromone-controlled reproduction in yeasts to mammals.
See also this comment by Frank Xavier on Eat Yourself to Live: Autophagy’s Role in Health and Disease
Amino acids are not all the same, EAA and NEAA messages epigenetically control sometimes univocal responses, but more often they rule opposing effects.
I wrote:
Thanks for mentioning that. In a recent interview about his forthcoming book, Carl Zimmer claimed
…we need to be much more skeptical about other forms of heredity, like epigenetics.
(edited) Food energy-dependent biophysically constrained viral latency has been linked to healthy longevity in all living genera via autophagy, in the context of fixation of RNA-mediated amino acid substitutions and game play in Cytosis, for ages 10+.
In that context, we included a section on molecular epigenetics in this 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior
Our claims have since been supported at every level of examination that now links the sun’s anti-entropic virucidal energy from electrons to ecosystems via cryo-EM technology and the creation of microRNAs.
See: Regulation of Luteinizing Hormone Receptor mRNA Expression in the Ovary: The Role of miR-122 and Regulation of FSH expression by differentially expressed miR-186-5p in rat anterior adenohypophyseal cells and Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells
The microRNA-mediated link from Vitamin C to ecological adaptations in a modern human population in China established the facts about alternative splicings of pre-mRNA that we included in our 1996 review. See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
See also: Reproductive role of miRNA in the hypothalamic-pituitary axis
See also: Chemistry at the nexus of water and energy
Our ability to harness reactions that absorb or release energy is often contingent on water as a mediator. We can appreciate this simply by considering the steam that drives our electricity-generating turbines, the rivers that flow through our hydroelectric plants, and the freshwater–saltwater interface from which we can harvest blue energy. Whether we split water (as plants do), make it (as a product of combustion) or just drink it, this compound is inexorably tied to energy. Chemistry is at the heart of these topics and this collection brings together content from across Nature Research that focuses on the chemistry of energy production and water treatment.
Philip C. Ball and Carl Zimmer continue to display their overwhelming ignorance of cell biology in two books:
Beyond Weird
We now realise that quantum mechanics is less about particles and waves, uncertainty and fuzziness, than a theory about information…
See for comparison: Life is physics and chemistry and communication and What is life when it is not protected from virus driven entropy
See also: She Has Her Mother’s Laugh: The Powers, Perversions, and Potential of Heredity
We need a new definition of what heredity is…
Both so-called science journalists have ignored everything known to serious scientists about biophysically constrained viral latency. They reach a very large target audience of others who are biologically uninformed.
In the context of those who are equally uninformed, so-called science journalists have the power to contribute to increasing amounts of unnecessary suffering and premature deaths. Only the emergence of Timothy J. Cunningham as director of the CDC is likely to stop them. May God help us all if Timothy J. Cunningham has somehow vanished without a trace and fails to return to put pseudoscientists and their idiot minions into their proper place.
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Epigenetics and autophagy vs mutations and evolution (3)
< 1 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (2)
2 MIN READ
0
Polycombic ecological adaptation as a science, not a theory (2)
12 MIN READ
0
Polycombic ecological adaptation as a science, not a theory
3 MIN READ
0
80 years of causal analysis (1936 – 2016)
11 MIN READ
0
Did evolution autophosphorylate your kinases? (3)
2 MIN READ
1
The natural success of RNAi and failed treatment
7 MIN READ
0
Pheromone-controlled autophagy
4 MIN READ
0
Hecatombic evolution via oncocers and oncohistones
9 MIN READ
0
Did evolution autophosphorylate your kinases?
5 MIN READ
1
Nutrient-dependent autophagy
3 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy (2)
6 MIN READ
0
The last RNA-mediated theory killer (2)
7 MIN READ
0
Asking the right questions (2)
3 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy
3 MIN READ
0
Life is energy-dependent task management (2)
3 MIN READ
0
Life is energy-dependent task management
3 MIN READ
0
Hypothesis free pseudoscience vs facts (5)
6 MIN READ
0
Hypothesis free pseudoscience vs facts (4)
5 MIN READ
0
Hypothesis free pseudoscience vs facts (1)
5 MIN READ
0
Chromatin: The structure of DNA
6 MIN READ
0
A working model of “captured” genes
6 MIN READ
0
DNA repair via junk DNA (2)
5 MIN READ
0
Displays of ecological adaptation (2)
3 MIN READ
0
DNA repair via junk DNA (1)
5 MIN READ
0
Unconstrained mutations, Zika virus, Kallmann’s syndrome
4 MIN READ
0
Linking RNA structure to function
3 MIN READ
0
Anthetical conclusions (2)
5 MIN READ
0
RNAi: From magic bullet to billion dollar baby
4 MIN READ
0
Pseudoscientists ignore what serious scientists prove
6 MIN READ
0
GC-rich neo-Darwinian train wreck
5 MIN READ
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The end of neo-Darwinism
5 MIN READ
0
The tipping point? 50,000 publications (5)
3 MIN READ
0
Invisible dark matter
< 1 MIN READ
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Placing boundaries where none exist
< 1 MIN READ
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Innate immunity and multiplexing
7 MIN READ
0
RNA methylation (2)
7 MIN READ
0
RNA methylation
2 MIN READ
0
Energy-dependent RNA methylation (7)
7 MIN READ
0
Energy-dependent RNA methylation (1)
6 MIN READ
0
Secular humanism and ecoterrorism
4 MIN READ
0
War Games: False Flag Terrorism
5 MIN READ
0
Virus-driven energy theft: definition?
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (2)
7 MIN READ
0
Millions of water molecules vs years of evolution
2 MIN READ
0
Confusing effects and affects of visual input
2 MIN READ
0
Nutrient-dependent life vs virus-driven pathology
4 MIN READ
0
Selective reporting of inferences: examples of pseudoscience
14 MIN READ
0
Ignore the evidence: Rachel Feltman
5 MIN READ
0
RNA-mediated DNA modifications
5 MIN READ
0
Center stage RNA-mediated events (since 1996)
3 MIN READ
0
Stress-induced energy-dependent DNA repair
4 MIN READ
0
Intelligent RNAs vs evolved genes
2 MIN READ
0
Did Brain Atrophy Evolve?
2 MIN READ
0
Researchers rename, reshuffle, and reveal their ignorance
3 MIN READ
0
RNA-mediated theory killers (5)
2 MIN READ
0
Ecological adaptations you cannot live without
6 MIN READ
0
Nutrient-dependent trophic analogs (2)
6 MIN READ
0
Essential pseudoscientific concepts of atheism
3 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (4)
6 MIN READ
0
Sulfated steroids and RNA-mediated identity codes
< 1 MIN READ
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Stress-perturbed mitochondrial dysfunction (2)
5 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Models are not theories (3)
3 MIN READ
0
RNA central and RNA-mediated.com
6 MIN READ
0
Ecological speciation. Get it, theorists?
< 1 MIN READ
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The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
700 million years of evolution?
5 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Metaphysical science vs theory
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Becoming biologically informed (2)
3 MIN READ
0
Is SUMOylation RNA-directed DNA methylation? (revisited)
4 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
RNA-mediated development (2)
< 1 MIN READ
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Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
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I forgot. How do mutations cause evolution?
4 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Viruses in gut microbes
4 MIN READ
0
pH, water, amino acids and protein folding
4 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Re-inventing a completely new thing
4 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
The Darwin Code by Greg Bear
13 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
The miRNA/mRNA balance: a suboptimal strategy?
2 MIN READ
0
MicroRNAs and memory
< 1 MIN READ
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Creating nothing but a theory (2)
4 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2 MIN READ
0
RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3 MIN READ
0
RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3 MIN READ
0
From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Sneaking up from behind
4 MIN READ
0
All of “like kind” (Part 2)
2 MIN READ
0
All of "like kind" in the (bigger) family
6 MIN READ
1
Constrained evolution is ecological adaptation
5 MIN READ
0
From Hydra to humans vs a Lakatosian research program
4 MIN READ
0
Jumping back: Science or Pseudoscience?
6 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
Meaningful dialogue, anonymous fools and idiot minions
4 MIN READ
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3 MIN READ
0
Sackler Colloquium: Effects or AFFECTS on Behavior
2 MIN READ
0
Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
0
Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
Pharmacogenomics
3 MIN READ
0
A model of MHC 'evolution'
2 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
ALPHA GENOMIX
7 MIN READ
2
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
2014 and 2004 Nobel Prize in Medicine
3 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Forces of "Nature" limit dissemination of information
4 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
Different physical locations and different molecular mechanisms of health and disease
2 MIN READ
0
Metabolism, fixation, health or neurodegerative disorder
2 MIN READ
0
Epigenetically-effected metabolic shifts and ecological adaptations
3 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
De novo gene Creation sans evolution of genes via mutations
4 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Miracles are not miracles to evolutionary theorists
2 MIN READ
0
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
Watching and waiting for more retractions
2 MIN READ
0
A molecular visualizer of worthwhile molecular biology
2 MIN READ
0
Behavior (3): All responses are RNA-mediated in bees
3 MIN READ
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2 MIN READ
0
Pattern recognition and conserved receptors (TAARs)
5 MIN READ
0
Nutrient-dependent erythropoiesis and anemia
6 MIN READ
0
A relatively young branch of science called epigenetics
4 MIN READ
0
Biophysically constrained beginnings of RNA and DNA
4 MIN READ
0
Baby talk: More misrepresentations of ecological adaptations
2 MIN READ
0
Comparing divergent model organisms
2 MIN READ
1
A microRNA-mediated mechanism that is epigenetically inherited
2 MIN READ
0
Order and disorder: Ecological adaptations not mutations
6 MIN READ
0
microRNAs differentiate neuronal cell types
3 MIN READ
0
microRNAs and species relationships
3 MIN READ
0
Drunks and Monkeys: Pseudoscientific nonsense
2 MIN READ
0
Behavior is receptor-mediated
10 MIN READ
0
Cell-type differentiation
2 MIN READ
0
Another powerful refutation of mutation-initiated natural selection
4 MIN READ
0
Understanding the role of mutations and evolution
4 MIN READ
0
Alzheimer's, microRNAs, and olfaction
< 1 MIN READ
0
Pheromones and cancer
4 MIN READ
0
Epigenetics and metabolism converge with pheromone production
2 MIN READ
0
Constraints on mutational drift
< 1 MIN READ
0
Epigenetic effects underlie sexual preferences IV
< 1 MIN READ
0
The hormone-miRNA axis, life span, and sexual orientation
3 MIN READ
0
The genetics myth meets the great pheromone myth
2 MIN READ
0
MicroRNA binds messenger RNA: Adaptive Evolution
< 1 MIN READ
0
Disorders of development: altered microRNA / messenger RNA balance
< 1 MIN READ
0
Eat like a monkey; act like a monkey
2 MIN READ
0
Evolution at work sans random mutations
2 MIN READ
0
Sex differences in Alzheimer's and everything else
2 MIN READ
0
Love is a receptor-mediated event: the pervasive influence of the late Robert L. Moss
3 MIN READ
0
Exercise Alters Epigenetics
2 MIN READ
0