Odor activation of ATP (1)

By: James V. Kohl | Published on: March 26, 2018

Serious scientists start from the levels of biological organization required to link atoms to ecosystems in all living genera. They must link what is known about quantized energy to subatomic particles. See for example slide number 6 from: Human Pheromones: Linking Neuroendocrinology and Ethology (revisited)  (2010)
Subatomic particles must be the link to the creation of ATP synthase, which must link the creation of ATP to the creation of RNA.
See McEwen et al., (1964) Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Odor activation of ATP completes the pathway that links the anti-entropic virucidal energy of sunlight to all quantized energy-dependent biophysically constrained RNA biosynthesis and viral latency. Viral latency links the physiology of pheromone-controlled reproduction to healthy longevity in species from microbes to other mammals and to humans.
See: ATP and Odor Mixture Activate TRPM5-Expressing Microvillous Cells and Potentially Induce Acetylcholine Release to Enhance Supporting Cell Endocytosis in Mouse Main Olfactory Epithelium

In sum, our results show that TRPM5-MCs dose-dependently respond to ATP and odor mixture and may release ACh to potentiate endocytosis in SCs, possibly promoting xenobiotic removal from the MOE. These results have unveiled cholinergic regulation in the MOE coordinating SC activity important for protecting the epithelium and airway. That TRPM5-MCs are sensitive to ATP and express multiple purinergic receptors also suggests an additional mechanism for the MOE to act in a concerted fashion with the rest of the respiratory mucosa to defend against xenobiotic insults. Taken together, these novel results of cholinergic paracrine signaling in the MOE increase our understanding of how the MOE maintains its function and prevents chemical-induced damage.

Simply put, the MOE links food odors and other sensory input to the pheromone-constrained viral latency presciently reported in:
Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.) (1994)

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

See for earlier and later publications in the English Language:
Gonadotropin releasing hormone and human sexual behavior (1991) in Neuropeptides and Psychiatric Disorders
Induction of FOS immunoreactivity in central accessory olfactory structures of the female rat following exposure to conspecific males (1992)

The findings indicate that exposure of female rats to reproductively relevant stimuli resulted in induction of fos-like immunoreactivity within the AOS and that both olfactory and nonolfactory cues probably contributed to this effect.

Influence of male rats on the luteinizing hormone-releasing hormone neuronal system in female rats: role of the vomeronasal organ (1993)

Olfactory information processed by the vomeronasal system is reported to influence reproductive functions in a variety of mammals. The present studies were designed to determine if male-associated cues affect the luteinizing hormone-releasing hormone (LHRH) neuronal system…

Vomeronasal organ-mediated induction of fos in the central accessory olfactory pathways in repetitively mated female rats (1994)

Removal of the VNO significantly reduced the enhancement of lordosis and the induction of fos immunoreactivity in luteinizing hormone-releasing hormone (LHRH) neurons in ovariectomized estrogen-primed rats.

Pheromones (2010) in Stress Science: Neuroendocrinology
See for comparison: The Expanding Landscape of Alternative Splicing Variation in Human Populations

Alternative splicing variation has been linked from the food energy-dependent pheromone-controlled physiology of reproduction to all extant biodiversity in species from microbes to humans.

Biologically uninformed theorists still think in terms of evolution.
See: The human microbiome in evolution
Most of them have no idea how to link subatomic particles to biophysically constrained viral latency.

Subatomic: An Atom Building Board Game

A deck-building game where particle physics & chemistry collide! Use quarks to build subatomic particles & particles to build Atoms!

See instead: Cytosis: A Cell Biology Board Game

A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!

See for comparison: Genetic variation in a human odorant receptor alters odour perception
Gene-centric theories about altered odor perception have failed to link energy-dependent top-down causation to biophysically constrained viral latency and healthy longevity. The ridiculous theories will continue to cause unnecessary suffering and premature death until pseudoscientists admit that they learned virtually nothing about RNA-mediated cell type differentiation during the past 20 years of scientific progress.
See for example, anything published by Leslie B. Vosshall
Specifically, Laying a controversial smell theory to rest (2015)

Some have pointed out that it is a waste of time to expend effort to refute a controversial theory that has few advocates, and that attention should be turned instead toward how smell works (, ).

This is how smell works: ATP and Odor Mixture Activate TRPM5-Expressing Microvillous Cells and Potentially Induce Acetylcholine Release to Enhance Supporting Cell Endocytosis in Mouse Main Olfactory Epithelium

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