Odor activation of ATP (2)
(click to enlarge)
Metabolic Regulation of Cytoplasmic DNA Synthesis (1974)
The curve that results when the rate of DNA synthesis is plotted as a function of ATP concentration is sigmoidal, suggesting that more than one site on the enzyme interacts with ATP and that these sites are acting cooperatively.
Odor activation of ATP is the obvious link to RNA-mediated feedback loops that control the food energy-dependent pheromone-controlled physiology of reproduction via the rate of DNA repair in species from microbes to humans.
See: “ATP activation ”
See for comparison: Feedback loops link odor and pheromone signaling with reproduction (2005)
See also: “ATP activation” microRNA ”
See also: Mapping malaria by combining parasite genomic and epidemiologic data
Here, we discuss the spatial epidemiology of malaria in the context of transmission-reduction interventions, and the challenges and promising directions for the development of integrated mapping, modeling, and genomic approaches that leverage disparate data sets to measure both connectivity and transmission.
The sun’s anti-entropic virucidal energy has been linked to protective food energy-dependent hemoglobin variants via 1700+ examples. The variants link interethnic similarities and differences to all extant human populations.
HbVar: A Database of Human Hemoglobin Variants and Thalassemias
SNPs or indels [insertions/deletions] link amino acid substitutions to hemoglobin variants. Molecular defects [mutations] in regulatory or coding regions of the human genes can minimally or drastically reduce their expression, leading to ฮฑ-, ฮฒ- or ฮด-thalassemia, respectively.
What can be said about so-called scientists and so-called science journalists who do not know the difference between how a food energy-dependent amino acid substitution is linked to ecological adaptations and how a mutation is linked to diseases?
Who was the first to say it?
VIDEO
Who will be the next to disagree:
7/25/13
Jay R. Feierman :
Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you donโt know that you have an incorrect understanding [of] Darwinian biological evolution.
Darwin repeatedly asserted that “conditions of life” must be placed before natural selection. Without the sun’s anti-entropic energy, no species on Earth can adapt to ecological variation.
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The stability of organized genomes (3)
3 MIN READ
0
Is the best Chinese research from China?
3 MIN READ
0
Viruses, amino acids, and somatic cell types (3)
9 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Riding the wrong direction
3 MIN READ
0
Decreased phenotypic variation: Faith in Facts
7 MIN READ
1
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
microRNAs and memory: Why trust a theory?
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
Virus-driven death by evolutionary theory
3 MIN READ
0
“Evolution” of sex differences?
2 MIN READ
0
RNA-mediated cell type differentiation: Honeybee
< 1 MIN READ
0
Theoretically, purifying selection is evolution
< 1 MIN READ
0
RNA-mediated development
2 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
Tweaking the story to fit the theory
5 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Five years of Ferguson
2 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
How to find a “holy grail” under your nose
3 MIN READ
0
MicroRNAs and the exposome
5 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Graphic misrepresentations of ecological adaptation
2 MIN READ
0
Too many targets for theories
3 MIN READ
0
Creating nothing but a theory (2)
4 MIN READ
0
Creating nothing but a theory
4 MIN READ
0
2 genes in 2 species (too expensive and too insignificant)
11 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
Epigenetics Skeptism
5 MIN READ
0
What about birds?
5 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Reverse phosphorylation
7 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
0
Military combat training to fight disease
3 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
Mute points: most are afraid to mention them
6 MIN READ
0
Beneficial microbes kill beneficial mutations
4 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
A single amino acid substitution differentiates cell types of E. coli
3 MIN READ
0
ISHE's human ethology group
2 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
0
The future of physics predicts no future for evolutionary theory
3 MIN READ
0
Meaningful dialogue, anonymous fools and idiot minions
4 MIN READ
0
Achiral GnRH: no prophesy, just prediction
9 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
RNA eclipses the importance of DNA to cell type differentiation
4 MIN READ
0
We need pattern recognition, not a prologue
6 MIN READ
0
From deep time into real time: What evolutionary processes?
10 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
Evolutionary theorists justify fear of the Ebola viruses
2 MIN READ
0
RNA-mediated genetic engineering (Part 3)
< 1 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
Ecological variation and niche construction: 1, 2, 3
6 MIN READ
0
Epigenetically-effected metabolic shifts and ecological adaptations
3 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
Do bacterial proteins evolve?
3 MIN READ
0
Probable changes in connectivity
2 MIN READ
0
Memory of repression and memory of behavior (2)
< 1 MIN READ
0
RNA-mediated species diversification from microbes to primates
3 MIN READ
0
Some neuroscientists think a mutation led to human language development
< 1 MIN READ
0
Genotype, observed phenotype, and distinctly disordered behaviors
3 MIN READ
0
Is the problem an internet echo or Feierman's ethics?
2 MIN READ
0
RNA-mediated ecological adaptation is not evolution
2 MIN READ
0
Mechanisms that are not understood increase clarity
4 MIN READ
2
Nutrient-dependent erythropoiesis and anemia
6 MIN READ
0
A microRNA-mediated mechanism that is epigenetically inherited
2 MIN READ
0
Epimutations: Attacking pseudoscientific dogmas
4 MIN READ
0
The quantum biology of consciousness
3 MIN READ
0
Behavior is receptor-mediated
10 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0
Cell-type differentiation
2 MIN READ
0
Darwinian theories vs Darwin's facts
2 MIN READ
0
Chromosomal rearrangements and ecological adaptations
4 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Jay R. Feierman
3 MIN READ
0
Alternative splicings (very technical)
2 MIN READ
0
Seeds of life: astrobiological theory and mutations theory
3 MIN READ
0
Nutrient-dependent pheromone-controlled stickleback evolution
2 MIN READ
0
Functional coding variants are not mutations
2 MIN READ
0
Random mutations: nothing adaptive in 3 billion years
< 1 MIN READ
0
A “new” view of evolution sans mutations
< 1 MIN READ
0
Adaptive evolution: Genetic selection against some disorders
3 MIN READ
0
Constraints on mutational drift
< 1 MIN READ
0
Random mutations theory and pervasive mosaic evolution (the brain)
2 MIN READ
0
Random mutations theory and pervasive mosaic evolution (the body)
2 MIN READ
0
Epigenetic effects on chromatin and regulatation of gene expression (in Archaea?)
2 MIN READ
0
The genetics myth meets the great pheromone myth
2 MIN READ
0
A key mutational event? That’s not very likely.
3 MIN READ
0
Creation vs Evolution: Expression of a newly found gene
2 MIN READ
0
More complicated than 1-2-3
2 MIN READ
0
Docosahexaenoic acid vs. creative use of mutations in natural selection
3 MIN READ
0
Biological facts constrain proponents of random mutations theory
2 MIN READ
0
Pre-existing genetic variability or random mutations: a matter of priorities and choices
2 MIN READ
0
Creation vs Evolution? Pre-existing genetic variation, not random mutation
2 MIN READ
0