Complexity: Routes and Patterns (2)

By: James V. Kohl | Published on: April 1, 2018

Role of RNA modifications in brain and behavior

“Here, we summarize current knowledge of cellular consequences of RNA modifications, with a special emphasis on neuropsychiatric disorders. We present evidence for the existence of an “RNA code,” similar to the histone code, that fine‐tunes gene expression in the nervous system by using combinations of different RNA modifications.”

Different RNA modifications were referred to as alternative splicings of pre-mRNA in the molecular epigenetics section of this 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior

“Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species…”

The mechanism, alternative splicing techniques of pre-mRNA, has since been linked by all serious scientists to the functional structure of supercoiled DNA.
See: Structural diversity of supercoiled DNA (2015)
Serious scientists will continue to ridicule pseudoscientists in parodies such as this one from December 2014.
All About that Base (Meghan Trainor Parody) 12/10/14


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