Abiogenesis vs microRNA biogenesis
(click to enlarge)
Summary: The pseudoscientific nonsense about abiogenesis that has been touted by Karo Michaelian and others like him has caused the unnecessary suffering and premature death of millions to billions of people by placing the pathogenic consequences of deregulated miRNAs into the context of ridiculous theories.Structural diversity of supercoiled DNA and the parody from the same research group:Abiogenesis (2017) Microscopic dissipative structuring and proliferation at the origin of life (Oct 13, 2017)
Some fundamental molecules of life are suggested to have been formed, proliferated, and evolved through photochemical microscopic dissipative structuring and autocatalytic proliferation under the UV-C/UV-B solar environment prevalent at Earth’s surface throughout the Archean. Evidence is given in the numerous salient characteristics of these, including their strong absorption in this spectral region and their rapid non-radiative excited state decay through inherent conical intersections. The examples of the dissipative structuring and dissipative proliferation of the purines and of single strand DNA are given. UV-C and UV-B-induced stationary state isomerizations and tautomerizations are shown to be crucial to the formation of the purines from hydrogen cyanide in an aqueous environment under UV-C light, while UV-C induced phosphorylation of nucleosides and denaturing of double helix RNA and DNA are similarly important to the production and proliferation of single strand DNA. This thermodynamic dissipation perspective provides a physical-chemical foundation for understanding the origin and evolution of life.
The suggestion is ridiculous. No serious scientist would claim that some fundamental molecules of life formed, proliferated, and evolved in the context of thermodynamic dissipation after the UV-C induced phosphorylation of nucleosides and denaturing of double helix RNA and DNA.microRNA biogenesis to all biophysically constrained food energy-dependent pheromone-controlled morphological and behavioral diversity on Earth.MicroRNA biogenesis (2018) microRNA Arthropod viruses and small RNAs (2013)
Understanding the role of small RNAs in arthropod host-virus molecular interactions will facilitate manipulation of these pathways for both management of arthropod pests of agricultural and medical importance, and for protection of beneficial arthropods such as honey bees and shrimp. This review highlights recent research on the role of small RNAs in arthropod host-virus interactions with reference to other host-pathogen systems.
Example: MicroRNAs as mediators of insect host-pathogen interactions and immunity
In this review, we will discuss the latest developments in regards to the role of microRNA in insect host-pathogen interactions and provide some insights into this rapidly developing area of research.
Example: miRNA regulation of innate immunity (2018)
MicroRNAs (miRNAs) are small noncoding RNA and are pivotal posttranscriptional regulators of both innate and adaptive immunity . They act by regulating the expression of multiple immune genes, thus, are the important elements to the complex immune regulatory network. Deregulated expression of specific miRNAs can lead to potential autoimmunity, immune tolerance, hyper-inflammatory phenotype, and cancer initiation and progression. In this review, we discuss the contributory pathways and mechanisms by which several miRNAs influence the development of innate immunity and fine-tune immune response. Moreover, we discuss the consequence of deregulated miRNAs and their pathogenic implications.
The pseudoscientific nonsense touted by Karo Michaelian and others like him has caused the unnecessary suffering and premature death of millions to billions of people by placing the pathogenic consequences of deregulated miRNAs into the context of ridiculous theories.Structural diversity of supercoiled DNA and the parody from the same research group:VIDEO Michaelian K Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication (Nov 23, 2017)Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
See also: Long-range coherence and energy storage in biological systems (1968)Cytosis (for ages 10+)
Players take turns placing workers on available organelles within a human cell in order to collect resources (such as Carbohydrates or ATP!) or take actions (such as purchasing Cell Component cards or translating mRNA into Proteins!)
Players use their resources to build Enzymes, Hormones, and Hormone Receptors and also to help detoxify the cell – all of which score health points. The player with the most health points at the end of the game wins!
See for comparison: DNA Denaturing through UV-C Photon Dissipation: A Possible Route to Archean Non-enzymatic Replication (2014)
Many of the fundamental molecules of life, those common to all three domains; bacteria, eukaryote, and archea, including RNA and DNA, amino acids, enzymes, vitamins, cofactors, and protoporphyrins, absorb photons in the UV-C 1. RNA or DNA in complexes with these molecules act as acceptor quenchers, providing the electronically excited pigment donor molecule with an extremely rapid (sub picosecond) non-radiative dexcitation channel, through internal conversion into vibrational energy of the nucleic acid and surrounding water molecules2.
On January 15, 2016 John Hewitt commented: You have just described the founding principle and thermodynamic function of life
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4
0
Virus-driven energy theft and premature death
3
0
Fighting for virus-driven pathology
5
0
Dobzhansky 1973 and precision medicine (5)
3
0
Atomic theory vs facts about hydrogen-atom transfer
4
0
Dobzhansky 1973 and Precision Medicine (2)
5
0
Trump’s appeal to common sense
2
0
Science journalists or paid propagandists? (4)
6
0
Dobzhansky 1973 and precision medicine
6
0
Twisted theories and weaponized facts
3
0
Autophagy: from pre-mRNAs to microRNAs, enhancers, QTLs et al.
6
0
Mutations: the “driving force” behind human brain complexity?
6
0
Mutations: the "driving force" behind human brain complexity?
6
0
Critical values expose virus-driven energy theft (2)
4
0
Theorists sell hidden energy (2)
4
0
Critical values expose virus-driven energy theft
6
0
Theorists sell hidden energy
3
0
Evolved patterns of brain stimulation
3
0
Chirality is reality
6
0
Energy-dependent hydrogen bonds in supercoiled DNA
7
0
Energy-dependent chirality
6
0
Energy-dependent alternative splicings 1996 – 2016 (2)
5
0
Vietnam Veterans and others with glioblastoma
3
0
Energy-dependent sensory maps (1996-2016)
5
0
Energy-dependent alternative splicings 1996 – 2016
12
0
Energy-dependent oscillating gene networks organize life
4
0
2016 obfuscated facts about energy as information
5
0
More refutations of neo-Darwinian nonsense
7
0
Re-inventing mutation-driven evolution (2)
4
0
Sudden death indel polymorphism
4
0
Anti-entropic virucidal energy as information
10
0
Explorers who do not know what is known (2)
6
0
Explorers who do not know what is known
4
0
Energy-dependent de novo creation and neurogenesis
7
0
Theories vs facts about polycombic adaptation
3
0
Tasting light links energy from creation to adaptation
9
0
Combating evolution: Battlefield medicine vs politicized science
6
0
The futility of The Battlefield FB group
10
0
Metabolic Phenotyping Research
2
0
Phylogenetic similarity sans energy
2
0
Happy biophysically constrained Thanksgiving (in the USA)
3
0
De novo gene creation: Ignoring the experimental evidence
7
0
Energy-dependent coulombic, autophagic, polycombic healthy longevity
4
0
Light, behavior and autophagy, a gender-specific risk factor
4
0
Controlled amino acid treatment of all pathology
4
0
Energy-dependent purifying selection / autophagy (2)
2
0
Energy-dependent purifying selection / autophagy (3)
2
0
Energy-dependent purifying selection / autophagy (5)
2
0
Energy-dependent purifying selection / autophagy (6)
3
0
Optogenetics: Let there be virucidal light!
2
0
Base pairs, amino acids and phenotypes
10
0
Survivors of RNA-mediated terrorism
5
0
Building delicious base pairs in class. It’s elementary Watson and Crick
3
0
Building delicious base pairs in class. It's elementary Watson and Crick
3
0
Energy-dependent maternal-to-zygotic transition
6
1
Virus-driven mutation or amino acid substitution
5
0
Epigenetically effected energy-dependent fluorescence
5
0
Epigenetics and autophagy vs mutations and evolution (5)
2
0
Coulombic interactions facilitate polycombic adaptation
5
0
Top-down adaptation vs bottom-up evolution
6
0
Polycombic ecological adaptation as a science, not a theory (2)
12
0
Polycombic ecological adaptation as a science, not a theory
3
0
Attacking Young Earth Creationists
5
0
80 years of causal analysis (1936 – 2016)
11
0
Did evolution autophosphorylate your kinases? (3)
2
1
The human virome (revisited)
4
0
The natural success of RNAi and failed treatment
7
0
Hecatombic evolution via oncocers and oncohistones
9
0
Did evolution autophosphorylate your kinases? (2)
5
1
Nutrient-dependent pheromone-controlled autophagy (2)
6
0
Nutrient-dependent pheromone-controlled autophagy
3
0
Life is energy-dependent task management (2)
3
0
Life is energy-dependent task management
3
0
Hypothesis free pseudoscience vs facts (5)
6
0
Hypothesis free pseudoscience vs facts (2)
5
0
The last RNA-mediated theory killer
< 1
0
Base pairs, olfaction and RNA thermometers
4
0
Chromatin: The structure of DNA
6
0
Consciousness is simply food rearranged
2
0
Hydrogen-atom energy in DNA base pairs
6
0
DNA repair via junk DNA (2)
5
0
The Aquatic Ape / Waterside Ape divergence
6
0
Light energy-dependent active motifs
6
0
Light energy-induced base pair changes (2)
4
0
Light energy-induced base pair changes (1)
6
0
Displays of ecological adaptation (2)
3
0
Displays of ecological adaptation
2
0
Virus-driven energy theft causes cancer
2
0
Linking RNA structure to function
3
0
How did the innate immune system evolve?
4
0
Plant microRNAs slow virus-driven aging
3
0
Increased soil pH and nutrient availability
4
0
Virus-driven energy theft: honeybee model
3
0
Antithetical conclusions (7)
3
0
Anthetical conclusions (2)
5
0
Antithetical conclusions (3)
3
0
Anthetical conclusions
3
0
RNAi: From magic bullet to billion dollar baby
4
0
Co-evolution and co-speciation replace neo-Darwinian nonsense
4
0
Pseudoscientists ignore what serious scientists prove
6
0
Food supplement or licensed immunostimulant?
6
0
Virus-driven downsizing of the human brain (3)
4
0
Biophotonics, glycobiology, quantized biodiversity (2)
19
0
The end of neo-Darwinism
5
0
Biophotonics, glycobiology, quantized biodiversity
4
0
The Origin of Information (2)
6
0
The Origin of Information (1)
6
0
Light ‘drives’ adaptation; nothing ‘drives’ evolution
6
0
Did “Nature” kill Steve Jobs? (3)
10
0
Funding the Human Genome Project-Write
2
0
RNA-mediated programming of E.coli
< 1
0
Virus-driven downsizing of the human brain (2)
< 1
0
Virus-driven downsizing of the human brain
2
0
MicroRNAs and sexual orientation
8
0
Innate immunity and multiplexing
7
0
Amino acids and virus penetration
3
0
RNA methylation
2
0
Model vs theory: Progress report!
8
0
Masters of deception about nature (2)
7
0
The Mind’s Eyes (revisited)
10
0
Cracking the Olfactory Code?
5
0
RNA methylation, behavior, and disease
6
0
Modelling life scientifically: RNA-mediated events
12
0
Energy-dependent RNA methylation (10)
4
0
Energy-dependent RNA methylation (8)
4
0
Energy-dependent RNA methylation (7)
7
0
Energy-dependent RNA methylation (6)
9
0
Energy-dependent RNA methylation (5)
3
0
Energy-dependent RNA methylation (3)
10
0
Energy-dependent RNA methylation (2)
5
0
Energy-dependent RNA methylation (1)
6
0
Secular humanism and ecoterrorism
4
0
Thermotolerance and longevity (2)
3
0
War Games: False Flag Terrorism
5
0
Energy-dependent biodiversity (2)
2
0
The tipping point? 50,000 publications (3)
6
0
Neo-Darwinism failed in 1995
3
0
Countdown to Genetics and Genomics
< 1
0
Energy-dependent creation and entropy
4
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics (2)
7
0
RNA-mediated physics, chemistry, and molecular epigenetics
9
0
RNA splicing, genetic variation, and disease
2
0
Wasted Templeton Funding (3)
2
0
Wasted Templeton Funding (2)
2
0
Millions of water molecules vs years of evolution
2
0
A bumper crop of virus-infected weeds and people
2
0
Molecular Diagnostics: What is unprotected life (4)
2
0
Molecular Diagnostics: What is unprotected life (3)
5
0
Molecular Microbial Ecology
8
0
Molecular Diagnostics: What is unprotected life? (2)
7
0
Molecular Diagnostics: What is unprotected life?
2
0
Creating and/or programming the immune system
< 1
0
Half truths support theories without facts
4
0
Ricki Lewis’ Time Machine (3)
5
0
Creating nutrient-dependent life with enough genes to survive
3
0
Confusing effects and affects of visual input
2
0
Selective reporting of inferences: examples of pseudoscience
14
0
Ignore the evidence: Rachel Feltman
5
0
Virus-driven disorder prevention and health promotion
6
0
Stress-linked population-level history dependence
5
0
Do not miss the misrepresentations
2
0
Energy dependent RNA-mediated immunity (3)
8
0
Energy-dependent RNA-mediated immunity (1)
10
0
RNA-mediated DNA modifications
5
0
Science vs semantics
4
0
From angstroms to ecosystems and entropy
2
0
Bacteria see the light and they adapt (2)
5
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3
0
Effects on invertebrate GnRH and affects on primate behavior
6
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA
2
0
Hydrogen-atom transfer in DNA base pairs (7)
5
0
Organic Compounds and the Miracle of Smell and Taste
7
0
Neuroscience Virtual Event vs AAAS Symposium
3
0
Cancer: Evolution 2.0’s Blind Spot
13
0
Ricki Lewis’ Time Machine (2)
6
0
Center stage RNA-mediated events (since 1996)
3
0
Blood test links atoms to ecosystems
2
0
Teleophobes vs teleophiles: a recent history
2
0
Ecological genomics: teleophobes respond (too late)
10
0
Genes, orchid odors, and pheromones from blonds
5
0
Amino acid substitutions, stress, and human behavior
3
0
Finding peace and π in the light of H bond energy (2)
8
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3
0
Finding peace and π in the light of H bond energy
5
0
Epigenetic (re)programming of behavior (3)
5
0
Perry Marshall: too much information for atheist PZ Myers
3
0
Assumptions prove ignorance (2)
5
0
Epigenetic (re)programming of behavior
4
0
Assumptions prove ignorance
5
0
Neo-Darwinian sink testing
2
0
NORAD: air defense and defense against genomic entropy
7
0
Life history transitions and RNA-mediated survial
2
0
Did Dobzhansky see the UV light of creation?
10
0
Researchers rename, reshuffle, and reveal their ignorance
3
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5
0
Manufacturing fossil “evidence”
4
0
RNA-mediated theory killers (4)
9
0
RNA-mediated theory killers (5)
2
0
RNA-mediated theory killers (3)
7
0
RNA-mediated theory killers (2)
8
0
RNA-mediated theory killers
6
0
Natural cooperation and Evolution 2.0
6
0
A two-faced protein enables RNA-mediated DNA repair (4)
6
0
A two-faced protein enables RNA-mediated DNA repair (3)
8
0
A two-faced protein enables RNA-mediated DNA repair (2)
4
0
Teaching the biologically uninformed
3
0
Sulfated steroids and RNA-mediated identity codes
< 1
0
Organization of biological sequences
2
0
Virally derived RNA molecules and cell types
2
0
Positive feedback loops and epigenetic traps
2
0
Stress-perturbed mitochondrial dysfunction (2)
5
0
Behavioral Immune System model
4
0
Stress-perturbed mitochondrial dysfunction
4
0
Understanding cell type differentiation
3
0
Theorists can’t understand biology
6
0
Sensationalizing no new mechanism
2
0
Too complex for the Complex Biological Systems Alliance
4
0
Receptor methylation controls behavior
2
0
Virus, transposon and plasmid evolution
< 1
0
Models are not theories (2)
2
0
Models are not theories (1)
2
0
Can veterans and other prisoners escape pseudoscience?
2
0
Unraveling the secrets of RNA-mediated events
2
0
RNA central and RNA-mediated.com
6
0
Ecological speciation. Get it, theorists?
< 1
0
Designing, engineering, and protecting biodiversity
3
0
The virome, microbiome, replisome and supercoiled DNA
2
0
Skip the politics; embrace the facts
5
0
Controled Stem Cell Expansion
3
0
Neo-Darwinian logic is nonsense
3
0
Human pheromone deniers: What’s next?
5
0
FREE* SAMPLE: Histone modification
4
0
700 million years of evolution?
5
0
Biophysically constrained or unconstrained?
2
0
Mutated mitochondrial genes vs Supercoiled DNA
2
0
Mystery machine vs medical intelligence
2
0
Epigenetic inheritance of stress-perturbed protein folding
2
0
Preventing genomic entropy
4
0
Molecule of life vs animal experiments
< 1
0
Keep the gay gene theory?
< 1
0
Supercoiled DNA constrains virus-driven genomic entropy
2
0
Let there be anti-entropic light (2)
4
0
Is mainstream science in “Science” pseudoscience?
5
0
Viruses come alive: Tree of life pseudoscience
6
0
Theorists have not seen the light (2)
3
0
Gene creation (revisited)
2
0
Hijacked light energy and vertebrate pathology
4
0
Theorists have not seen the light
4
0
Alternative pre-mRNA splicing and ecological adaptation
7
0
From fertilization to RNA-mediated events and back
2
0
Phytochemical link from the sun to cell types
2
0
Genome sequencing, cadherins, and quantum consciousness
6
0
Anti-entropic containment of energy: symbiosis 1.0
5
0
The “great filter” is an epigenetic trap
4
0
Dead-end theories about the cat
4
0
The stability of organized genomes (3)
3
0
Viruses, amino acids, and somatic cell types (2)
5
0
Picornaviruses moving between primates (or not)
2
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6
0
Becoming biologically informed (2)
3
0
Is SUMOylation RNA-directed DNA methylation? (revisited)
4
0
“New” epigenetic mechanism for lifelong learning?
3
0
The sum of our RNA-mediated parts
2
0
Protein folding and Google page rank
2
0
RNA-mediated development (2)
< 1
0
Alternative splicings: epigenetics meets pharmacogenomics
4
0
Epigenetic regulation of aging by glycine and GnRH
5
0
Pattern recognition: biogeochemical structure and function
5
0
Viruses and the human-like microbiome
3
0
Informing the biologically uninformed
< 1
0
I forgot. How do mutations cause evolution?
4
0
Ignoring systems complexity (it’s too complicated)
3
0
Virus-driven cancer treatment and prevention
2
0
A special issue on nutritional epigenetics
5
0
Retinoic acid + one receptor regulate the genome
3
0
Epigenetics: microRNAs effect an integrative pathway
4
0
Physics, chemistry, light, and life
2
0
An epigenetic mark links algae, worms, and flies
2
0
RNA-mediated silencing of a chromosome
3
0
Viruses, proteins, and gut metagenomes do not evolve
< 1
0
DNA Methylation and organized genomes
7
0
Amino acid-dependent cell type differentiation
8
0
Mutisensory integration: watching the paradigm shift
12
0
Origin of life and cancer (1,2,3)
2
0
Silencing genes and serious scientists
3
0
Life: conserved ion and amino acid transporters
3
0
MicroRNAs and memory
< 1
0
Creating nothing but a theory (2)
4
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4
0
Quantum correlations/pseudoscience
3
0
Mimicking claims and ignoring facts
4
0
Correctly modeling ecological adaptation
4
0
UV-light mutations and gene loss (not gain)
5
0
Virus-driven origin of life
2
0
Luis P. Villarreal tells it like it is
3
0
Is DNA-directed transcription RNA-mediated?
2
0
RNA directed DNA methylation and cell types
4
0
From 3-D to epigenetically-effected 4-D genome make-up
5
0
Nutritional epigenetics, exercise, and immune system integrity
4
0
Military combat training to fight disease (2)
3
0
Military combat training to fight disease
3
0
Are viruses microRNAs? (2)
5
0
Are viruses microRNAs?
3
0
Sneaking up from behind
4
0
All of “like kind” (Part 2)
2
0
Environment epigenetically shapes the immune system
3
0
Beneficial microbes kill beneficial mutations
4
0
Unified nutritional and molecular mechanisms
9
0
Models by evolutionary biologists are not models
2
0
The future of physics predicts no future for evolutionary theory
3
0
Model organisms: the birds and the bees
3
0
Chemical ecology and RNA-mediated control of DNA loops
< 1
0
Jumping back: Science or Pseudoscience? (2)
2
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3
0
Eliminating correlations from evolutionary ecology
6
0
The key to science: experimental evidence
5
0
Biologists puzzled by evolved RNAs and decaying DNA
6
0
Nothing new under the sun, except pseudoscientific nonsense
6
0
Intelligent viruses and cancers?
10
0
De novo DNA methylation?
3
0
Pharmacogenomics
3
0
Sexual differentiation of cell types in plants
2
0
Are evolutionary theorists 'nob ends'?
5
2
No excuses: Creation and the meaning of organismal complexity
7
0
RNA-mediated events: chromosomal rearrangements and genomic rearrangements
2
2
RNA-mediated genetic engineering (Part 3)
< 1
0
RNA-mediated cell type differentiation and behavior
3
0
Stop evolutionary theorists. Kill cancers
3
0
RNA-directed DNA methylation and RNA-mediated events
5
1
A microRNA-mediated mechanism that is epigenetically inherited
2
0
Order and disorder: Ecological adaptations not mutations
6
0
microRNAs differentiate neuronal cell types
3
0
microRNAs and species relationships
3
0
Drunks and Monkeys: Pseudoscientific nonsense
2
0
Ecologically linked adapted ants and brains
2
0
Another powerful refutation of mutation-initiated natural selection
4
0
Don't tell the Creationists
2
0
Targeting a cancer gene
2
0
Pulses of olfactory/pheromonal input
2
0
Alzheimer's, microRNAs, and olfaction
< 1
0
Constraints on mutational drift
< 1
0
Epigenetic effects underlie sexual preferences IV
< 1
0
The hormone-miRNA axis, life span, and sexual orientation
3
0
MicroRNA binds messenger RNA: Adaptive Evolution
< 1
0
Disorders of development: altered microRNA / messenger RNA balance
< 1
0
Evolution at work sans random mutations
2
0
Sex differences in Alzheimer's and everything else
2
0
(click to enlarge)