MicroRNA-mediated denuclearization (4)
(click to enlarge)
Summary: Christ’s lab showed that in vivo formation of I-motif structures is pH dependent and helped to put the “fear of God” into atheistic communists.
I-motif DNA structures are formed in the nuclei of human cells (4/23/18)
Reported as: In human cells, scientists find DNA that looks like a twisted knot instead of a double helix (4/23/18)
Also reported as: New Twisted ‘Knot’ Human DNA Structure Discovered—and It Looks Nothing Like the Double Helix (4/23/18)
Christ’s lab showed that in vivo formation of I-motif structures is pH dependent. Clearly, the potential of hydrogen (pH) and pH-dependent cell cycles link the quantized energy of virucidal sunlight to protection from the degradation of messenger RNA that links mutations to all pathology. Virus-mediated archaeal hecatomb in the deep seafloor
We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.
Until recently, the pseudoscientific nonsense about vaccines that could protect human populations from the forthcoming viral apocalypse was tightly linked from communism to atheism. For comparison, Christ’s lab appears to have put the fear of God into its proper context; the 1918 Spanish flu.Structural diversity of supercoiled DNA (2015) and parodied in:VIDEO The Pharmacology of Regenerative Medicine (2013)Energy as information and constrained endogenous RNA interference (2017)
Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.
The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.
This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA.
Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution.
The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.
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6
0
Sensationalizing no new mechanism
2
0
More re-evolved functional structures?
2
0
Conserved molecular mechanisms
< 1
0
Models are not theories (2)
2
0
Cancer: forward and reverse
2
0
Mechanisms of stress: from genes to cancer
9
0
Viruses come alive: Tree of life pseudoscience
6
0
Rs3827760 is Val370Ala and EDARV370A
3
0
From “Blood Music” to Evolution 2.0
5
0
Viruses, amino acids, and somatic cell types
4
0
Hematopoiesis and practopoiesis
4
0
RNA-mediated morphological AND behavioral phenotypes
2
0
MicroRNA controlled growth and brain development
7
0
Protein folding and Google page rank
2
0
Amino acid substitutions are not mutations
2
0
What I cannot create I eliminate from discussion
3
0
Creating and maintaining the human virome
2
0
microRNAs, glycosylation, and genomes
4
0
I forgot. How do mutations cause evolution?
4
0
Gene expression, immortality, and cancer
6
0
Computing via phosphorylation and fixation
3
0
Epigenetics: microRNAs effect an integrative pathway
4
0
Finding odor and taste receptors everywhere
6
0
Misunderstanding cancer
7
0
The Darwin Code by Greg Bear
13
0
Nutrient-dependent RNA interference
4
0
The miRNA/mRNA balance: a suboptimal strategy?
2
0
Methylation maintains cell type differences
3
0
Creating nothing but a theory
4
0
RNA-directed gene choice
5
0
Implicating microRNAs in cancer
2
0
RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3
0
RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3
0
An epigenetic trap (the prequel)
5
0
Nutritional epigenetics, exercise, and immune system integrity
4
0
Are viruses microRNAs? (2)
5
0
Sneaking up from behind (2)
3
0
Physicists: Desperate Acts
16
0
A single amino acid substitution differentiates cell types of E. coli
3
0
Glycine and GnRH: Am I being pedantic?
4
0
Meaningful dialogue, anonymous fools and idiot minions
4
0
RNA-mediated species specificity
2
0
Ecological adaptations reported as evolution in insects and mammals
4
0
Nothing new under the sun, except pseudoscientific nonsense
6
0
RNA eclipses the importance of DNA to cell type differentiation
4
0
We need pattern recognition, not proclamations
3
0
Are evolutionary theorists 'nob ends'?
5
2
ALPHA GENOMIX
7
2
No excuses: Creation and the meaning of organismal complexity
7
0
Nutrient-dependent gene duplication in plants (but not animals?)
4
0
Evolutionary theorists and evolutionary theists live under rocks
< 1
0
RNA-mediated events: chromosomal rearrangements and genomic rearrangements
2
2
RNA-mediated events are not a matter of faith
2
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2
0
Different physical locations and different molecular mechanisms of health and disease
2
0
Physics denied; pseudoscientific nonsense accepted
2
0
Evolving DNA before RNA
4
0
Stop evolutionary theorists. Kill cancers
3
0
RNA-directed DNA methylation and RNA-mediated events
5
1
Mathematical model: microRNA and epigenetic regulation
2
0
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3
0
Nutrient-dependent pheromone-controlled exercise-induced physiques
< 1
0
RNA-mediated species diversification from microbes to primates
3
0
Evolutionary heritage or ecological adaptation? Racism versus reality
4
0
Biophysically constrained beginnings of RNA and DNA
4
0
Genes and Race: Human History?
2
0
Darwinian theories vs Darwin's facts
2
0
Nutrient-dependent pheromone-controlled stickleback evolution
2
0
Understanding the role of mutations and evolution
4
0
Pheromones and cancer
4
0
FDA: Just says NO — to ineffective drugs with side effects
< 1
0
More than speculation: adaptive evolution in species from microbes to man
2
0
(click to enlarge)