MicroRNA-mediated denuclearization (5)

By: James V. Kohl | Published on: April 25, 2018

Summary: The quantized energy linked to RNA synthesis (1964) is biophysically constrained (1968) in the context of RNA-directed DNA methylation and the physiology of reproduction that links food energy-dependent fixation of amino acid substitutions to cell type differentiation in all cell types of all individuals of all living genera.
Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Long-range coherence and energy storage in biological systems (1968)

…if energy is supplied above a certain mean rate to such a branch, then a steady state will be reached in which a single mode of this branch is very strongly excited. The supplied energy is thus not completely thermalized but stored in a highly ordered fashion.

Simply put, the quantized energy that is linked to RNA synthesis is biophysically constrained in the context of RNA-directed DNA methylation and the physiology of reproduction, which links food energy-dependent fixation of amino acid substitutions to cell type differentiation in all cell types of all individuals of all living genera.
See also: A comprehensive and quantitative exploration of thousands of viral genomes

Noncoding DNA is an umbrella term for … functional RNAs such as micro RNAs (miRNA), regulatory elements… as well as transposons and pseudogenes.

The anti-entropic energy-dependent creation of microRNAs links biophysically constrained viral latency to sympatric speciation not to the evolution of one species from another.
See for comparison: The evolving landscape of epigenomics: Measuring and manipulating methylation
One of the presenters published: Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology, which was reported as: DNA methylation plays key role in stem cell differentiation

…patients with ALS exhibit a high rate of genetic variants associated with the DMNT3A enzyme—another puzzling link.

The link from the energy-dependent creation of microRNAs to the creation of the enyzme and to RNA-methylation and DNA methylation is not a puzzling link. The puzzling link is portrayed in the context of de novo methylation. Methylation is nutrient-energy-dependent. It does not automagically occur outside the context of the energy that is required for enyzyme-dependent RNA biogenesis.
Another presenter published Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism
De novo CNVs do not exist in the world of serious scientists. All CNVs and all duplications are food energy-dependent and RNA-mediated in the context of the physiology of pheromone-controlled reproduction, which biophysically constrains viral latency.
See also, presenter Sean Sanders is a co-author of Partial Depletion of Intracellular ATP Mediates the Stress-Survival Function of the PCPH Oncoprotein

Consistent with its intrinsic ATP diphosphohydrolase activity, expression of the PCPH oncoprotein in cultured cells has now been shown to result in partial depletion of intracellular ATP and consequent inhibition of the c-JUN NH2-terminal kinase-mediated stress signaling pathway.

He is the only one of the three presenters during this Webinar who is likely to link the anti-entropic virucidal quantized energy of sunlight from the creation of ATP synthase to the creation of ATP and the creation of enzymes via the creation of microRNAs that biophysically constrain RNA in the context of the first two works cited above, which were published in 1964 and in 1968.
50 years of research reports that established the links from energy-dependent cell type differentiation to healthy longevity are consistently missing from Webinars that supposedly exist to teach what is known about biologically-based cause and effect. The webinars often are presented by those who have learned nothing about the molecular mechanisms of energy-dependent RNA-mediated recombination.
But see: Mechanisms of Recombination conference

Understanding precisely how recombination occurs is of interest to workers in the fields of meiosis, DNA repair, replication, chromosome architecture and interactions, and chromatin biology.

See for comparison: Three years ago, I was traveling and visiting friends. I posted links to these articles on my personal FB page, but did not elaborate on the significance of the information in blog posts about the links from the creation of sunlight and the creation of RNA to energy storage in biological systems.
Investigators show how immune cells are ‘educated’ not to attack beneficial bacteria

…once they leave the thymus, T cells are again educated in the , or gut, to leave beneficial bacteria alone. This dual education strategy is vital to supporting healthy immune function…

This claim supports the claims about biophysically constrained RNA-mediated cell type differentiation from 1964 and 1968. Without a model of biophysically constrained viral latency and cell type differentiation, these other studies cannot be linked to any explanation of biologically-based cause and effect.
Study sheds new light on brain’s source of power

Our digestive system converts carbohydrates found in food into glucose, a sugar molecule that is the body’s main source of energy, which is then transported throughout the body via the blood system. Once inside cells, the mitochondria, which serve as tiny cellular power plants, combine these sugars with oxygen to generate energy.

Unlike the rest of the body, the brain maintains its own unique ecosystem.

The brain’s source of power is quantized energy within the context of its unique ecosystem

Antibiotics Found to Have Unexpected Effects on Mitochondria

…these molecules have a significant effect on mitochondria, the cell’s “powerhouses.”

“It’s not that surprising, given that mitochondria are historically bacteria that evolved within our cells,” says Mouchiroud.

Anti-entropic virucidal energy from the sun is the source of the cell’s “powerhouse.” The claim that mitochondria are historically bacteria that evolved within our cells is a regurgitation of pseudoscientific nonsense.
Study describes brain circuitry for selecting among sensations

These studies showed that the frequency-dependent switching of thalamic cells between inhibition and excitation was associated with different balances of activity among all three of these receptors.

See: Olfaction Warps Visual Time Perception
The anti-entropic virucidal energy of sunlight was linked from the physiology of reproduction in bacteria to our visual perception of energy and mass across the time-space continuum.
Major depression leaves a metabolic mark

“Our most notable finding is that the amount of mitochondrial DNA changes in response to stress,” says Professor Jonathan Flint of the University of Oxford.

Mitochondria are compartments in cells responsible for generating energy. An increase in mitochondrial DNA suggests a change in mitochondria and cellular energetics, Flint explains.

“We see an unexpected link between cellular energetics and , which has always been seen as a mood disorder.”

Why would a link from cellular energetics to major depression be unexpected in the context of what is known about the virus-driven degradation of messenger RNA?
Fat signals control energy levels in the brain

An enzyme secreted by the body’s fat tissue controls energy levels in the brain…

The claim about the enzyme do not fit the claim about the control of energy levels in the brain by fat tissue. Obviously, the enzyme is linked to metabolism, which is how energy levels in the brain are controlled.
Each of these reports serves only to confuse those who would otherwise learn that the sun’s anti-entropic virucidal energy controls every aspect of the molecular mechanisms of cell type differentiation that are linked from the creation of microRNAs to all biodiversity on Earth via the physiology of reproduction.

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