Epigenetic inheritance of spatiotemporal regulation (2)

By: James V. Kohl | Published on: May 23, 2018

See: Epigenetic inheritance of spatiotemporal regulation
Summary: Food energy-dependent changes in base pairs have repeatedly been linked to spatiotemporal regulation of mRNA translation via the pheromone-controlled physiology of reproduction and microRNA-mediated amino acid substitutions that stabilize organized genomes.
See:  Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes

One SNP rs4713668 (P=4.62 × 10−4) identified in our study, was in LD (r2=0.65) with rs3227, which is one of the three variants recently reported with genome-wide significant evidence of association with educational attainment.46

See also: Critical Issues in BDNF Val66Met Genetic Studies of Neuropsychiatric Disorders

Brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the brain. Its Val66Met polymorphism (rs6265) is a common and functional single-nucleotide polymorphism (SNP) affecting the activity-dependent release of BDNF.

Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression

…epigenetic regulation of BDNF by HDAC5 plays an important role in the learned helplessness model of depression.

Redefining neuroendocrinology: Epigenetics of brain-body communication over the life course

This article is both an account of an emerging field elucidating brain-body interactions at multiple levels, from molecules to social organization, as well as a personal account of my laboratory’s role and, most importantly, the roles of trainees and colleagues, along with my involvement in interdisciplinary groups working on this topic.

Natural selection is not mentioned. There is one mention of evolution and one mention of mutation.  Everything known to serious scientists about biophysically constrained cell type differentiation and healthy longevity begins with Levels of Biological Organization that must be linked to all biodiversity via energy-dependent changes in base pairs and fixation of amino acid substitutions, see slide #6
Simply put, energy-dependent biophysically constrained viral latency links subatomic particles to supercoiled DNA, which protects all organized genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology.
But see: Protein complexes are assemblies of subunits that have co-evolved to execute one or many coordinated functions in the cellular environment.
The published work was reported as: Cancer gene dependency maps help reveal proteins’ relationships

“Dependency” mapping reveals the genetic adaptations cancer cells make to survive.

There is no such thing as a genetic adaptation in a cancer cell. The facts about energy-dependent RNA-mediated cell type differentiation are a threat to theorists and to Big Pharma, as represented in this claim.

How the Trump budget undercuts security risks posed by pandemics

In the last four years, we have faced the Ebola epidemic – contained after significant loss of life – and Zika, which is still not contained. Collectively, we will feel these effects for a generation, while children born with Zika-related defects and their families will feel the effects every day of their lives.

The so called “Trump budget” increased NIH funding by in 2018. See:  President Signs FY 2018 Omnibus with $3 Billion NIH Increase, Boost for Other Health Programs
Ebola Erupts Again in Africa, Only Now There’s a Vaccine
No matter how much more money is available, the loss of key people such as Timothy J. Cunningham from the CDC will continue to prevent or retard scientific progress.

Body of Missing C.D.C. Employee Found in Atlanta River April 5, 2018

Cunningham… studied the health differences between people from various backgrounds, including race, gender, geography and class, according to his biography on the CDC’s website. Cunningham has also been deployed to help during public health emergencies, including Superstorm Sandy and the Ebola and Zika viruses…

His job title was: Team Lead, Division of Population Health National Center for Chronic Disease Prevention and Health Promotion. Selected publications from a list of 33. Timothy J. Cunningham, ScD

Vital Signs: Racial Disparities in Age-Specific Mortality Among Blacks or African Americans — United States, 1999–2015

Racial/ethnic disparities in self-reported short sleep duration among US-born and foreign-born adults

Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states

Associations between antioxidants and all-cause mortality among US adults with obstructive lung function

Health and Safety Issues for Travelers Attending the World Cup and Summer Olympic and Paralympic Games in Brazil, 2014 to 2016

I don’t know of any other researcher from the CDC who might link what Timothy J. Cunningham knew about food energy, antioxidants and mortality from viral latency to protection from the virus-driven degradation of messenger RNA that other intelligent scientists have linked from mutations to all pathology. The Health and Safety issues of travelers extend to the issues of Homeland Security each time a virus from another species adapts to a human host.
The rVSV-ZEBOV vaccine was in development for many years before the 2014 outbreak, but no one paid for clinical trials to prove it worked.
Since then, food energy-dependent RNA interference has begun to take center stage in the proper response to the forthcoming viral apocalypse, but the W.H.O. still touts vaccines.
See for comparison: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events
By showing the God-less Communists that vaccines could not prevent the decimation that would follow after a virus adapted in malnourished humans, scientific creationists in South Korea forced denuclearization.
SARCASM ALERT Now that I’ve told you that, I will have to kill myself.
The only hope to prevent the next viral apocalypse will be to acknowledge the level of the threat, which was placed into its proper context in 2013.
See: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution
Editor’s summary:

Five antigenic sites in the virus surface hemagglutinin protein, which together comprise 131 amino acid positions, are thought to determine the full scope of antigenic drift of influenza A virus. Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.

Abstract (conclusion):

Substitution of a single amino acid at one of these positions substantially changed the virus-specific antibody response in infected ferrets. These findings have potentially far-reaching consequences for understanding the evolutionary mechanisms that govern influenza viruses.

The virus-driven theft of quantized energy as information links adaptations in viruses to pathology in all species. The food energy-dependent pheromone-controlled physiology of reproduction protects all organized genomes from viruses by enabling the ecological adaptation of all species.
For comparison, see this pseudoscientific nonsense:

Mammals Made By Viruses (2012)

Human Genome Includes ‘Foreign’ Genes Not from Our Ancestors (2015)

All serious scientists have dismissed the claims of theorists and many intelligent people have dismissed the claims of so-called science journalists.
See also: Single-nucleotide polymorphism rs948854 in human galanin gene and multiple sclerosis: a gender-specific risk factor
See also: Sunlight could reduce risk of multiple sclerosis, study says
The anti-entropic virucidal energy of UV light will be linked to all biophysically constrained biodiversity during Schrödinger at 75 – The Future of Biology – September 2018
Selected presentation by: Nick Lane

Lane is an evolutionary biochemist and writer in the Department of Genetics, Evolution and Environment, University College London. He was awarded the inaugural Provost’s Venture Research Prize for his research on evolutionary biochemistry and bioenergetics in 2009. His work focuses on the origin of life, and the origin and evolution of eukaryotes.

See for comparison: Linda Buck

Professor Buck is an American biologist best known for her work on the olfactory system. She was awarded the 2004 Nobel Prize in Physiology or Medicine, along with Richard Axel, for their work on olfactory receptors. Through years of intensive research, Buck became the first to identify a family of genes that control the olfactory system, a complex network that governs our sense of smell. Uncovering how this system works has been fundamental to understanding the machinery that controls the relay of sensory signals from the world around us to the central nervous system. These landmark contributions to human biology open new doors to studying the brain and have numerous implications for health.

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