Epigenetic inheritance of spatiotemporal regulation (2)
See: Epigenetic inheritance of spatiotemporal regulation
Summary: Food energy-dependent changes in base pairs have repeatedly been linked to spatiotemporal regulation of mRNA translation via the pheromone-controlled physiology of reproduction and microRNA-mediated amino acid substitutions that stabilize organized genomes.
See: Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes
One SNP rs4713668 (P=4.62 × 10−4) identified in our study, was in LD (r2=0.65) with rs3227, which is one of the three variants recently reported with genome-wide significant evidence of association with educational attainment.46
Brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the brain. Its Val66Met polymorphism (rs6265) is a common and functional single-nucleotide polymorphism (SNP) affecting the activity-dependent release of BDNF.
…epigenetic regulation of BDNF by HDAC5 plays an important role in the learned helplessness model of depression.
This article is both an account of an emerging field elucidating brain-body interactions at multiple levels, from molecules to social organization, as well as a personal account of my laboratory’s role and, most importantly, the roles of trainees and colleagues, along with my involvement in interdisciplinary groups working on this topic.
Natural selection is not mentioned. There is one mention of evolution and one mention of mutation. Everything known to serious scientists about biophysically constrained cell type differentiation and healthy longevity begins with Levels of Biological Organization that must be linked to all biodiversity via energy-dependent changes in base pairs and fixation of amino acid substitutions, see slide #6
Simply put, energy-dependent biophysically constrained viral latency links subatomic particles to supercoiled DNA, which protects all organized genomes from the virus-driven degradation of messenger RNA that links mutations to all pathology.
But see: Protein complexes are assemblies of subunits that have co-evolved to execute one or many coordinated functions in the cellular environment.
The published work was reported as: Cancer gene dependency maps help reveal proteins’ relationships
“Dependency” mapping reveals the genetic adaptations cancer cells make to survive.
There is no such thing as a genetic adaptation in a cancer cell. The facts about energy-dependent RNA-mediated cell type differentiation are a threat to theorists and to Big Pharma, as represented in this claim.