Every aspect of life is microRNA-mediated (2)

By: James V. Kohl | Published on: June 6, 2018

This recently published invited review was submitted as an invited review for the journal “Nutrients” in 2014. See: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (April 2018) In 2014, it was returned without review and I posted the preprint here:
Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
In 1995, I co-authored The Scent of Eros: Mysteries of Odor in Human Sexuality  We linked ecological variation to ecological adaptation via the food energy-dependent pheromone-controlled physiology of reproduction. Some peers hated us then. Some still do. Others simply pretended to ignore us and wrote books in attempts to “save face.”
Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull
Dr Stuart Ritchie, an academic psychologist, is one of the losers. See: Bodley Head signs ‘Freakonomics-style’ peer-reviews exposé (June 2018)

The Bodley Head has signed a book that exposes the “bias, hype, incompetence and fraud” in the peer-reviewed world by Dr Stuart Ritchie following a four-way auction.

Will Hammond, deputy publishing director at The Bodley Head, acquired UK and Commonwealth rights in Hypeology from Will Francis at Janklow & Nesbit.

Hypeology will explain how “bad practice and dodgy results have become endemic in contemporary science”, and it will provide a “devastating and gripping take-down of the over-simplified way many of us – including scientists – present and interpret even those results that are reliable”. It will also be a “celebration of everything that is great about science, a manifesto for a better and more rigorous way of thinking about scientific data and its importance for society, and it will provide the reader with a toolkit for spotting bad science for themselves in order to save science from itself”.

See also: When facts are not enough

Science is based on a shared respect for the scientific method—the principle that, by gathering and analyzing data and information, scientists and others can draw conclusions that are robust and generalizable across cultures and ideologies. Scientists furthermore assume that disagreements can be resolved by more facts. So when people object to the reality of climate change with science-y sounding arguments—“the data is wrong,” or “it’s just a natural cycle,” or even, “we need to study it longer”—the natural response of scientists is simple and direct: People need more data. But this approach often doesn’t work and can even backfire. Why? Because when it comes to climate change, science-y sounding objections are a mere smokescreen to hide the real reasons, which have much more to do with identity and ideology than data and facts.

See also: Congo: MSF Ebola vaccination begins 6/29/18

The current outbreak was declared on 8 May, in the northwest of the country. As of 28 May 2018, there have been 35 confirmed cases of Ebola resulting in 12 deaths, according to figures from DRC’s Ministry of Health.

See: Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources. Because many of the mutations alter protein sequences and other biologically meaningful targets…

Senior author Pardis Sabeti has since co-authored Nucleic acid detection with CRISPR-Cas13a/C2c2
The ability to detect food energy-dependent single-base differences links a range of health-related single-nucleotide polymorphisms (SNPs) from the creation and fixation of amino acid substitutions to differences in patient outcomes.
In 2013, Sabeti’s group reported that the EDAR V370A substitution linked the physiology of food energy-dependent pheromone-controlled reproduction in the mouse-to-human model of ecological adaptation to the stability of organized genomes in a population of humans in what is now Central China.
See: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant
A companion paper led the way for my conclusions in Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (April 2018)
See: Identifying Recent Adaptations in Large-Scale Genomic Data
Sabeti is not alone. Her co-authors also failed to link biophysically constrained viral latency to ecological adaptations and they continue to place their claims back into the context of neo-Darwinian nonsense about mutations and evolution.
The Ebola vaccine is proof of their human idiocy. They fail to recognize that the quantized energy of food is the key to ecological adaptions manifested in viral latency. It is not polite to mention the displays of human idiocy and FB censors stand ready to cancel the accounts of anyone who complains, which is what Richard Feynman did many years ago.
See:

See for comparison: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (April 2018)
Concluding paragraphs:

The plausibility and ecological validity of Kohl’s Laws in the context of Darwin’s ‘conditions of life’ can be compared to theories about biologically-based cause and effect in the context of species diversity. In mammals, for example, the explanatory power of a model of ecological variation and biophysically constrained nutrient-dependent pheromone-controlled ecological adaptations became clear with companion papers published in 2013. See for review [26].

The companion papers [159,160] told a new short story of ecological adaptations. In the context of climate change and changes in diet, the story began with what probably was a nutrient-dependent base pair change and a variant epiallele that arose in a human population in what is now central China. Apparently, the effect of the epiallele was adaptive and it was manifested in the context of an effect on sweat, skin, hair, and teeth. In another mammal, such as the mouse, the effect on sweat, skin, hair, and teeth is probably due to a nutrient-dependent epigenetic effect on hormones responsible for the tweaking of immense gene networks that metabolize nutrients to pheromones. The pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated.

The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [159,160]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.


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