Virus-driven genome engineering causes cancer?

By: James V. Kohl | Published on: June 13, 2018

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

Inhibition of p53 prevents the damage response and increases the rate of homologous recombination…

In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference

See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells

We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs.

Reported as: A serious new hurdle for CRISPR: Edited cells might cause cancer, two studies find

See also: microRNA + p53 Search results (Items: 1 to 20 of 1959)

Inhibitory effect of microRNA-154 targeting WHSC1 on cell proliferation of human skin squamous cell carcinoma through mediating the P53 signaling pathway.

I had several squamous cell carcinomas that required excisions before I leaned that Vitamin B3 was preventative.

Study: Vitamin B3 might help against skin cancer

See also: Paraptosis in human glioblastoma cell line induced by curcumin

Our data, strongly suggest that curcumin exerts its cell-death properties by affecting the integrity of the reticulum, leading to paraptosis in the glioblastoma cells. These data unveils the versatility of curcumin to control cancer progression.

I started taking curcumin (Tumeric) last year.

See also: microRNA + hematopoiesis

See also: microRNA + polycythemia 

Expression analysis of microRNA-125 in patients with polycythemia vera and essential thrombocythemia and correlation with JAK2 allele burden and laboratory findings

The curcumin and vitamin B3 may be controlling my stress-linked polycythemia. In any case, it is clear that the DNA damage response is quantized energy-dependent and it occurs in the context of light-activated endogenous substrates and naturally occurring RNA interference.

See also: Scientists eradicate cancer cells through dual targeting of DNA repair mechanisms

…plans to continue investigating alternative DNA repair pathways, which are essential for tumor cells but expendable in normal cells.

I reiterate: All DNA repair pathways are quantized energy-dependent. The repair pathways link UV light to Hydrogen-Atom Transfer in G⋅C Watson–Crick DNA Base Pairs in Solution  in the context of “UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair”  via control of pH responsive amino acid substitutions that prevent the virus-driven degradation of messenger RNA, which all serious scientists have linked to all pathology.
Scientists who pretend not to know the facts about disease prevention are like war criminals who commit crimes against humanity. But their crime is touting ridiculous theories or contributing to pseudoscientific nonsense about evolution that is touted by others.
See for comparison: A scientist named George Church has a wild idea to upend evolution — here’s what you should know about him (2017)
You should know about his patent on the naturally occurring molecular mechanisms of RNA-Guided Human Genome Engineering.
He cannot upend evolution. He is simply telling the truth about energy-dependent  biophysically constrained viral latency and ecological adaptations.

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