MicroRNA-mediated feedback loops, structure, and function

By: James V. Kohl | Published on: June 25, 2018

Epithelial mesenchymal transition Transcription Factor (TF): The structure, function and microRNA feedback loop

TF-miR interaction provides a feedback or feedforward loop and cross-gene regulation consequently.

All feedback and feedforward loops linked to cross-gene regulation are quantized energy-dependent. The quantized energy is biophysically constrained in the context of microRNA biogenesis and fixation of RNA-mediated amino acid substitutions that differentiate the cell types of all individuals of all living genera. Fixation is controlled by the physiology of reproduction. Pheromones, for example, typically biophysically constrain all pathology.
See: Quantized Energy Links Olfaction from Angstroms to Ecosystems Part 1 and Quantized Energy Links Olfaction from Angstroms to Ecosystems Part 2
For review see:  Learning from Bacteria about Natural Information Processing
MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination
Towards elucidating the connection between epithelial–mesenchymal transitions and stemness
Stability of the hybrid epithelial/mesenchymal phenotype
See also my 2014 invited review of nutritional epigenetics: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems


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