Hashem Al-Ghaili vs Schrödinger at 75 (2)

By: James V. Kohl | Published on: July 23, 2018

See: The tipping point (revisited): 75,000 publications 7/13/18 and The tipping point (revisited): 75,000 publications (2) 7/15/18
Very few serious scientists do not know what happens after a paradigm shift has virtually eliminated a ridiculous theory from any further consideration whatsoever.
See: Kalevi Kull: Censorship & Royal Society Evo Event

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull

The losers are here:
Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity (with my emphasis) 7/19/18

…Acr-phages often need to cooperate in order to overcome CRISPR resistance, with a first phage blocking the host CRISPR-Cas immune system to allow a second Acr-phage to successfully replicate. This cooperation leads to epidemiological tipping points in which the initial density of Acr-phage tips the balance from phage extinction to a phage epidemic.

Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity 7/23/18

…infections fail when phage population numbers fall below a critical threshold.

The quantized energy-dependent creation of microRNAs biophysically constrains epidemiological tipping points in the context of the pheromone-controlled physiology of reproduction in species from microbes to humans. Pheromones biophysically constrain viral latency in human populations that exist when phage populations are maintained below a critical threshold.
All serious scientists know that the quantized energy-dependent creation of microRNAs prevents the degradation of messenger RNA that links the virus-driven theft of quantized energy to what is known about the Virus-mediated archaeal hecatomb in the deep seafloor

In deep-sea ecosystems, archaea and bacteria drive major nutrient cycles, and viruses are largely responsible for their mortality, thereby exerting important controls on microbial dynamics.

Simply put, viruses kill bacteria that do not find enough quantized energy as information in food to support their pheromone-controlled physiology of reproduction.

That fact is buried in the losers’ reports on Bacteriophage Cooperation and Anti-CRISPR Phages. All facts are placed back into the context of evolution.
See: Viruses cooperate to defeat bacteria (with my emphasis) 7/23/18

Bacteria continually evolve new mechanisms of resistance against viruses, while phages evolve countermeasures to overcome these defence mechanisms.

The authors refuse to acknowledge the facts that the late Eshel Ben-Jacob included in his life’s works on quantized energy-dependent information processing.
See for example: Learning from Bacteria about Natural Information Processing (2009), which was cited by these published works: Number of times cited: 25
The number of times the article has been cited can be placed into the context of the fact that you must pay to see the article. Those who could afford to pay cited this monograph, but many researchers have not read it.
You may want to accept the fact that the author focused on energy, matter, and thermodynamic imbalances that Schrodinger claimed were essential to biophysically constrained life. All serious scientists know that life requires the consumption of negative entropy. Eshel Ben-Jacob proposed that organisms sense the environment to extract latent embedded information, and quantized energy-dependent RNA-mediated viral latency has since been linked to healthy longevity at every level of biological organization and every level of examination.
See: MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination (2013)
See also: Stability of the hybrid epithelial/mesenchymal phenotype (2016)

Epithelial-to-Mesenchymal Transition (EMT) and its reverse – Mesenchymal to Epithelial Transition (MET) – are hallmarks of cellular plasticity during embryonic development and cancer metastasis.

Here, we identify certain ‘phenotypic stability factors’ (PSFs) such as GRHL2 that couple to the core EMT decision-making circuit (miR-200/ZEB) and stabilize hybrid E/M phenotype.

…the (miR-200/ZEB) loop that has been proposed to act as a three-way switch – enabling three phenotypes – E (high miR-200,low ZEB), M (low miR-200, high ZEB), and hybrid E/M (medium miR-200, medium ZEB) [].

A similar set of results is also observed for the (miR-200/ZEB/miR-145/OCT4) circuit…

Simply put, the quantized energy-dependent core EMT decision-making circuit (miR-200/ZEB) guides the organism’s functioning and stabilizes the phenotypes of all living genera. The problem for biologically uninformed theorists who continue to tout their nonsense about evolution is that:

“…EMT-stemness interplay is regulated by coupling between the core EMT module (miR-200/ZEB).”

The coupling is quantized energy-dependent and the quantized energy is typically found in sunlight or in the food that organisms eat. For example, more than 100 published works mention microRNA-200  and more than 600 published works mention mir-200.
More importantly, those published works are among the 75,000  published works that have already linked the light energy-dependent creation of microRNAs from biophysically constrained viral latency to all biodiversity on Earth via the physiology of reproduction in bacteria and humans.
See Cytosis for ages 10+ and learn how

“Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!”

At the same time, you will learn that evolutionary theorists of all ages have always been losers. The losers failed to start from the creation of the sun’s anti-entropic virucidal energy and link the energy from the physiology of reproduction to all biophysically constrained viral latency and all biodiversity on Earth.
See also: Nearly 7500 tweets have received very few responses from serious scientists, and losers have virtually ignored them. Some of the losers have blocked me so they do not see any more links from the creation of light to the creation of biodiversity via the food energy-dependent physiology of reproduction. That proves some, if not all, theorists are examples of willful ignorance and human idiocy.

Thank God, I am not the only person to have made that claim about willful ignorance and human idiocy. See also:

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements.

The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA.

Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes. For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution.

The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.


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