MicroRNA-mediated feedback loops (1)

By: James V. Kohl | Published on: July 23, 2018

miR-181d-5p-FOXP1 feedback loop modulates the progression of osteosarcoma (2018)

In conclusion, our study revealed that miR-181d-5p-FOXP1 feedback loop modulates cell proliferation and metastasis in osteosarcoma.

See for comparison: Feedback loops link odor and pheromone signaling with reproduction (2005)
See for pattern recognition:  Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems
See for an example of failed pattern recognition: Polymorphisms of dopamine receptor genes DRD2 and DRD4 in African populations of Hadza and Datoga differing in the level of culturally permitted aggression

…we failed to identify any associations of DRD2 rs1800497, DRD4 120 bp Ins, or DRD4 exon III polymorphisms with aggression. Thus, our data have no strong evidence to support the involvement of polymorphisms of DRD2 and DRD4 in controlling aggressive behavior.

See for comparison:  Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

Given the dramatic changes of synaptic dopamine during adolescence, it has been suggested that effects of COMT Val158Met genotypes might have oppositional effects in adolescents and adults.

The failure to recognize how dramatic changes of synaptic dopamine vary during development contributes to the failure of pseudoscientists to link effects on COMT Val158Met to prevention of school shootings and other gun violence. This leads to the claims of the biologically uninformed masses who think that gun ownership legislation is the answer to the problem biologically uninformed theorists have left the generations of the future to deal with.
The problem is the ignorance of the past. That’s typical. Ignorance has always been a problem.
Fix your problem. Learn how microRNA-mediated feedback loops biophysically constrain all mental and physical pathology.
Until then, don’t push.

‘Stand your ground’ law means no jail time for man who shot a young father


Notify of
Inline Feedbacks
View all comments

Want more on the same topic?

Swipe/Drag Left and Right To Browse Related Posts: