Evolved to adapt: a biophysically constrained impossibility (three)

By: James V. Kohl | Published on: August 6, 2018

RNA-directed DNA methylation links the creation of light from microRNA biogenesis to biophysically constrained viral latency
The role of control region mitochondrial DNA mutations in cardiovascular disease: stroke and myocardial infarction (August 1, 2018) RNA Day

Recent studies associated certain type of cardiovascular disease (CVD) with specific mitochondrial DNA (mtDNA) defects, mainly driven by the central role of mitochondria in cellular metabolism. Considering the importance of the control region (CR) on the regulation of the mtDNA gene expression, the aim of the present study was to investigate the role of the mtDNA CR mutations in two CVDs: stroke and myocardial infarction (MI). Both, fixed and heteroplasmy mutations of the mtDNA CR in two population samples of demographically-matched case and controls, were analysed…

See also: Human adaptation to extreme environmental conditions
It’s great to see others realize that they cannot keep playing the mutation-driven evolution game now that the cell biology game for ages 10+ links ATP from the creation of RNA to biophysically constrained viral latency and all biodiversity.
See: Cytosis
See for comparison Human expression QTLs are enriched in signals of environmental adaptation (2013)

Environmental correlation is a way of detecting adaptation by testing whether the spatial distribution of the frequency of an allele could be explained by an environmental factor.

See for comparison: Reappraising the human mitochondrial DNA recombination dogma and  The role of control region mitochondrial DNA mutations in cardiovascular disease: stroke and myocardial infarction
See also: Genome-wide repressive capacity of promoter DNA methylation is revealed through epigenomic manipulation
RNA Day competition was fierce. I’m glad that Cristina Santos’ group won and I hope they get all the funding others lost.
I wonder if any others besides this group tried to steal her thunder via obfuscation?
See: Diverse endogenous retroviruses generate structural variation between human genomes via LTR recombination
RNA-directed DNA methylation links the creation of light from microRNA biogenesis to biophysically constrained viral latency
For examples of biophysically constrained viral latency
See: microRNA and
cardiovascular disease
stroke
myocardial infarction


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