Evolved to adapt: a biophysically constrained impossibility (four)

By: James V. Kohl | Published on: August 8, 2018

Therapeutic potential of microRNAs in osteoporosis function by regulating the biology of cells related to bone homeostasis
If organisms evolved to adapt, we would not see articles that claim

..deregulation of the miRNA-mediated mechanism has emerged as an important pathological factor…

and the therapeutic potential of microRNAs would continue to be ignored.
See also: It’s evolution vs ecological adaptation again, and Jon Lieff led the way with the obfuscation of facts. He wrote:

Deepwater rice grows normally in shallow water but in heavy floods increases its height in keeping with rising water levels, to enable the plants to ride out lengthy floods.

On 7/28/18 he reported: Rice plants evolve to adapt to flooding

…a biosynthesis enzyme of gibberellin—a plant hormone… orchestrates the deepwater rice response via a unique gain-of-function allele.

In the world of theorists, gain of function alleles are like a superhero who saves the day for their ridiculous theories. In the real world, quantized energy-dependent biophysically constrained gain of function alleles have been linked from the speed of light on contact with water to the creation of enzymes and hormones via the physiology of reproduction and the constraints on receptor-mediated function in all living genera. That fact was included in this report, which links quantized energy-dependent top-down causation from changes in angstroms to changes in ecosystem at the level of subatomic particles.
See for comparison: A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

… these results suggest it is possible to predict phase-separation properties based on amino acid sequences.

…we do not fully understand the sequence-intrinsic features that drive phase separation or control material properties of condensates of FUS family proteins.

Thanks to Oded Rechavi for ensuring that I did not miss this.
See also: Phenomenally designed hemoglobin

Comparative studies also have been conducted on the genes and gene clusters that encode the hemoglobins, revealing a rich history of gene duplications and losses as well as translocations.9

Why don’t young earth creationists cite what is known to all serious scientists about the hemoglobin variants.
The claim that “…we do not fully understand the sequence-intrinsic features…” of proteins can be viewed in the context of what is understood about the pathology of Alzheimer’s disease.
But first, see: Updates of the HbVar database of human hemoglobin variants and thalassemia mutations

Hemoglobinopathies are the commonest single-gene genetic disorders in humans, resulting from pathogenic genome variants in the human α-like and β-like globin gene clusters (reviewed in 1). Single nucleotide substitutions or indels [INsertions/DELetionS] can lead to several hemoglobin variants owing to amino acid replacements, while molecular defects in either regulatory or coding regions of the human HBA2, HBA1, HBB or HBD genes can minimally or drastically reduce their expression, leading to α-, β- or δ-thalassemia, respectively.

Watch as everything know about fixation of RNA-mediated amino acid substitutions in the organized genomes of all species is put back into the context of ridiculous theories.
See: De novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations

Our results underline the need of a set of human reference genomes that includes a comprehensive list of alternative haplotypes to depict the complete spectrum of genetic diversity across populations.

Their results fail to link quantized energy-dependent microRNA biogenesis to healthy longevity, which means their results fail to link the virus-driven theft of quantized energy to all pathology.
See:  Herpes Viruses and Senile Dementia: First Population Evidence for a Causal Link
The virus-driven theft of quanitized energy is the causal link which was reported as: Alzheimer’s disease risk impacted by the liver, diet

The creation of ATP and the creation of RNAs are quantized energy-dependent. Human herpes viruses were causally linked to the virus-driven degradation of messenger RNA and mutations that cause all pathology. That means the failure of Medical Express to include a link to the study of Alzheimer’s could be placed into the context of a crime against humanity — if burying the facts could ever been considered a crime.

Most people will never know how much obfuscation of top-down causation is reported in published works like this one (from Jan 25, 2018):  Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

The failure to report that the creation of the sun’s anti-entropic virucidal light has been linked from naturally occurring RNA interference to prevention of all pathology, including Alzheimer’s, is an especially important indicator of mass media treachery when the report from Medical Express comes 6 months later.

Each time I do not see a link to the study that’s reported by Medical Express, I ask “Why not provide a link to the study that’s being reported?” The answer is clear. They don’t what others to ask why everything known to scientific creationists about microRNA biogenesis links microRNAs to RNA interference and prevention of all pathology.

See also: Molecular basis of Gender Dysphoria: androgen and estrogen receptor interaction

An inverse allele interaction between ERβ and AR is characteristic of the MtF population: when either of these polymorphisms is short, the other is long. ERβ and ERα are also associated with transsexualism in the FtM population although there was no interaction between the polymorphisms. Our data show that ERβ plays a key role in the typical brain differentiation of humans. Conclusion ERβ plays a key role in human gender differentiation in males and females.

The interaction among the polymorphisms is quantized energy-dependent. The energy-dependent creation of the receptors differentiates all cell types in all living genera. Gender dysphoria is a form of virus-driven pathology that can readily be linked to sexual orientation in yeast cells.

See: From Fertilization to Adult Sexual Behavior

Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus…

See also:  A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

…plants alter microRNA (miRNA) biogenesis in response to light transition.

See also: Photosynthetic Energy Transfer at the Quantum/Classical Border

See for comparison: The Neuroscience of Consciousness – with Anil Seth (2/1/17: 1 hour)

Oded Rechavi blocked me from seeing his Tweets when he finally realized that consciousness does not exist outside this context: A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

… these results suggest it is possible to predict phase-separation properties based on amino acid sequences.”

The results link quantized energy-dependent changes in electrons to every level of niche construction (including socio-cognitive niche construction) via subatomic particles and the levels of biological organization that all serious scientists have linked from the physiology of reproduction and viral latency to all biophysically constrained biodiversity.

See for comparison: Energy as information and constrained endogenous RNA interference (2/15/17 less than 7 minutes)

See also:  Engineered Adaptability: Adaptive Solutions Are Targeted, Not Trial-and-Error

See for comparison: The Oded Rechavi Lab

It is likely that this award cost the government of Israel millions of dollars in funding that they will need to spend to catch up to what is being reported by scientific creationists who have linked the creation of sunlight to microRNA biogenesis and viral latency, which links God’s creation of the sun to all biodiversity via the physiology of reproduction in Biblical Genesis.

Meet Dr. Oded Rechavi, 2018 Blavatnik Awards in Israel Laureate in Life Sciences

See for comparison: Science in East Asia — by the numbers  The R&D spending graph shows that research in South Korea from 1996 to 2016 established the so-called “creationist capital of the world” as the world’s current leader.

South Korea ploughs a whopping 4.24% of its gross domestic product (GDP) into science and technology — neck and neck with Israel.

See for comparison: Journal of Genetic and DNA research invites geneticists, DNA experts, counsellors, medical professionals, clinical and diagnostic practitioners, researchers and students for submission of articles in genetics. Submission information:

I encourage others to submit manuscripts that attest to facts represented in articles like this: “… MicroRNA Production Is Required for a Proper Developmental Response…

…plants alter microRNA (miRNA) biogenesis in response to light transition.

Together, the works of serious scientists will force the works of theorists to include facts about the how the creation of sunlight and microRNA biogenesis. The facts link what organisms eat from the pheromone-controlled physiology of reproduction to biophysically constrained viral latency in species from microbes to humans.

To see how some scientists stifle scientific progress by refusing to discuss it, see my Tweets from 7/27/18 before Oded Rechavi blocked me:

Local tuning biases in mouse primary visual cortex | Journal of Neurophysiology The tuning is quantized energy-dependent and microRNA biogenesis constrains viral latency.

We presciently reported facts about RNA-directed DNA methylation in our 1996 Hormones and Behavior review of RNA-mediated cell type differentiation. From Fertilization to Adult Sexual Behavior Other serious scientists read it, and some cited it.

The lab discovered how the creation of sunlight is linked to viral latency and biophysically constrained biodiversity via microRNA biogenesis, the physiology of reproduction, and RNA-directed DNA methylation but failed to report it.

The late, Eshel Ben-Jacob (from Israel) was no loser. How many serious scientists have heard of him? If researchers in Israel, such as have not cited people link Ben-Jacob, who are they citing, and why. Few others linked the creation of energy to mircroRNA biogenesis

Now others should know why blocked me. See: Biomechanical Characteristics of Hand Coordination [retracted] ” …our study can improve the understanding of the human hand and confirm… the proper design by the Creator…”

Science in East Asia — by the numbers The R&D spending graph shows that research in South Korea from 1996 to 2016 established the so-called “creationist capital of the world” as the world’s current leader. R&D spending in Israel is increased to catch up.

Expect others from Israel to block me as they try to catch up or make it appear that they do not belong to the party of losers, who lost the battle with Young Earth Creationists from South Korea. See: Kalevi Kull: Censorship & Royal Society Evo Event

“Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge.” — Kalevi Kull

The late, Eshel Ben-Jacob (from Israel) was no loser. How many serious scientists have heard of him? If researchers in Israel, such as have not cited people link Ben-Jacob, who are they citing, and why. Few others linked the creation of energy to microRNA biogenesis

“Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.” open access at Join other serious scientist who have been ROTFL their AO since the 2005 publication of “Feedback loops link odor and pheromone signaling with…”

Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism (2015) have been linked to “A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation.” and viral latency. See:

Stability-mediated epistasis constrains the evolution of an influenza protein All serious scientists know that proteins do not evolve. ICYMI Thanks to for calling attention to that fact. Look to others like him to see the anti-entropic light.

My compliment led to this: You are blocked from following and viewing ‘s Tweets. Learn more

What don’t serious scientists like about the fact that proteins do not evolve? Why do pseudoscientists also love to proclaim that amino acids evolve?

Reported as: Giant neurons in the brain may play similarly giant role in awareness and cognition

In Pfaff’s view, the neurons are so critical for the normal functions of the central nervous system that they have evolved the ability to control their own blood supply directly.

As the editor of The Physiology of Reproduction (1992), Pfaff touts pseudoscientific nonsense about the evolution of cell type differentiation instead of linking the energy-dependent creation of all cell types from receptors to behavior in the context of gender dysphoria.


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