RNA Velocity (revisited) 4

By: James V. Kohl | Published on: August 13, 2018

Summary: Use of the term aptamers instead of nucleic acid ligands obfuscates cause and effect that is attributed to changes in the microRNA/messenger RNA balance, which link quantized energy as information from sunlight to biophysically constrained viral latency.

Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

…mutational bias is associated with increased numbers of hydrophobic tumor antigens and a better response to immune checkpoint inhibitors independent of mutational load. Taken together, our findings demonstrate that UCD is a common feature of tumors that profoundly affects carcinogenesis, mutagenesis, and immunotherapy response.

Mutational bias is biophysically constrained by quantized energy-dependent microRNA biogenesis.
Reported as: Disrupted nitrogen metabolism might spell cancer

…one of the enzymes in the urea cycle has been inactivated within many cancerous tumors, increasing the availability of nitrogen for the synthesis of an organic substance called pyrimidine, which, in turn, supports RNA and DNA synthesis and cancerous growth.

The creation of all enzymes is quantized energy-dependent. It links microRNA biogenesis to biophysically constrained autophagy. The ridiculous portrayal of biophysically constrained autophagy  in the context of RNA velocity but outside the context of energy-dependent top-down causation attests to the human idiocy displayed by all theorists.
For another example of human idiocy, see: Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines

This demonstration of aptamer-mediated, cell-internalizing delivery of large RNAs with retention of functional structure raises the possibility of manipulating endosomes and cells by delivering large aptamers and regulatory RNAs.

Reported as: Researchers create specialized delivery methods to help treat cancer, other disorders

Using a molecular process that mimics a highly-accelerated form of natural evolution, Porciani and his team sought out nucleic acid ligands, or aptamers.

The creation of regulatory RNAs is quantized energy-dependent in the context of light-activated microRNA biogenesis.

See: A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

…plants alter microRNA (miRNA) biogenesis in response to light transition.

Use of the term aptamers instead of nucleic acid ligands obfuscates cause and effect that is attributed to changes in the microRNA/messenger RNA balance, which link quantized energy as information from sunlight to biophysically constrained viral latency.

There is no known form of natural evolution except in the context of the hecatombic evolution of virus-driven pathology. See: Virus-mediated archaeal hecatomb in the deep seafloor

Natural selection for energy-dependent codon optimality links polycombic adaptations from fixation of amino acid substitutions to healthy longevity. That fact makes it clear that many other researchers are attempting to obfuscate what is known about how energy-dependent changes in base pairs are linked to fixation of RNA-mediated amino acid substitutions. The substitutions differentiate the cell types of all living genera via protection from the virus-driven degradation of messenger RNA that links mutations to all pathology.


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