Light-activated polycombic ecological adaptations vs hecatombic pathology (1)

(click to enlarge)

Conclusion:

1. The origin and adaptive evolution of domesticated populations of yeast from Far East Asia;
2. Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk; and
3. Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems have one thing in common.

They link the creation of quantized energy to light-activated microRNA biogenesis and biophysically constrained viral latency. The EDAR V370A variants in the mouse to human model of ecological adaptations link changes in one base pair to fixation of one amino acid substitution that stabilizes the organized genomes of mice and humans in the context of the stability of organized genomes in yeasts.
See: From Fertilization to Adult Sexual Behavior (1996)
My summary: Epigenetic effects on small DNA-binding proteins called “chromo domain” proteins affect chromatin structure in telomeric regions. The “chromo domain” proteins are called polycomb proteins.
The epigenetic effects of food and pheromones alter the transcription of polycomb proteins. Food and pheromones effectively silence various genes. Simply put, see Feedback loops link odor and pheromone signaling with reproduction (2005)
In our 1996 Hormones and Behavior review of epigenetically-effected RNA-mediated cell type differentiation, we linked the silencing of various genes from polycombic ecological adaptations to what is now known about how to prevent the virus-driven hecatombic evolution of pathology in species from yeasts to humans. We briefly mentioned this fact:

“…even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus (Runge and Zakian, 1996; Wu and Haber, 1995).”

See: Runge, K. W., and Zakian, V. A. (1996). TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 3094-3105.
See also: Wu, X., and Haber, J. E. (1995). MATa donor preference in yeast mating-type switching: Activation of a large chromosomal region for recombination. Genes Dev. 9, 1922-1932.
The most recent citation to Runge and Zakian (1996) appears to be Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast (2017)

Author summary

Significance:

Our study provides an example of a cell changing the folded state of one of its chromosomes in response to an internal chemical cue (DNA break), thereby affecting its function (DNA repair).

Although two other articles I published are listed, the most recent article that I did not publish is listed among similar articles to Diamond, Binstock and Kohl (1996), which was cited in:
Testosterone in utero and at birth dictates how stressful experience will affect learning in adulthood

…cognitive responses to stress appear to be masculinized by exposure to testosterone and feminized by its absence during very early development.

Our review of food energy-dependent pheromone-controlled  RNA-mediated hormone effected cell type differentiation appears to have effectively been buried in claims that link virtually anything else besides food odors and pheromones to every aspect of biophysically constrained cell type differentiation that led to publication of Olfaction Warps Visual Time Perception (2018). Advance online publication 17 March 2017. This link opens the pdf.

…any influence of olfaction on visual temporal processing would be due to olfactory-visual integration per se rather than added temporal information from the olfactory channel.

Conclusion:

In physics, space-time is warped by the distribution of mass and energy in it (Hwaking 1988). Our findings, along with others (Johnston et al. 2006; Xuan et al. 2007; Wang and Jiang 2012;
Mayo and Sommer 2013), suggest a parallel in the perception of time––subjective time is “warped” by the neural energy involved in representing multisensory inputs at subsecond scales.

My summary: The authors linked the sense of smell in bacteria from the pheromone-controlled physiology of reproduction to our visual perception of mass and energy in the context of the time-space continuum and all biophysically constrained morphological and behavioral phenotypes in all individuals of all living genera. Sex differences in our visual perception of mass and energy in the context of the time-space continuum are conditioned via exposure to food odors and pheromones.
See also: Sex differences in learning processes of classical and operant conditioning
See for comparison: Human Vision Can Sense a Single Photon 8 August 2016

“To our knowledge, these experiments provide the first evidence for the direct perception of a single photon by humans.”1

The claims that evolutionary pressures/evolutionary optimization led to Direct detection of a single photon by humans have since been placed into the context of how virucidal light biophysically constrains light-activated microRNA biogenesis.
The problem for theorists was summarized by Richard P. Feynman when he tried but failed to tell his father how the light in a photon was created.
Richard Feynman – The Pleasure of Finding Things Out  (video) At 13:40 he discusses the answer to his father’s question about where the light in a photon comes from.
Neo-Darwinian theorists refuse to address that question, which is why their their theories have no explanatory power for comparison to Darwin’s claims about “conditions of life.” All his conditions of life were presciently placed into the context of light-activated microRNA biogenesis and biophysically constrained viral latency by what is now known about the difference in the energy of two photons.
OLYMPUS experiment sheds light on structure of protons

…two photons are indeed exchanged during electron-proton interactions.

However, unlike the theoretical predictions, analysis of the OLYMPUS measurements suggests that, most of the time, only one of the photons has high energy, while the other must carry very little energy indeed, according to Richard Milner, a professor of physics and member of the Laboratory for Nuclear Science’s Hadronic Physics Group, who led the experiment.

The resurrection of claims made in From Fertilization to Adult Sexual Behavior (1996) can be viewed in the context of links from ecological adaptations in yeasts to ecological adaptations in humans.
See: The origin and adaptive evolution of domesticated populations of yeast from Far East Asia

The earliest evidence for fermented wine-like beverage production dates back to Neolithic times about 9000 years ago in China¹. S. cerevisiae has also been extensively studied as a model in physiology, genetics, and molecular biology and became the first eukaryote to have its genome completely sequenced².

For comparison see: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

The difference between 9000 years and 20,000 years of positive selection for the EDAR V370A allele was placed into the context of this invited review of nutritional epigenetics, which refutes the pseudoscientific nonsense about adaptive evolution and replaces the nonsense with claims that differentiate ecological adaptations from the evolution of virus-driven pathology during the past 6000 years.
See also: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)
See also: Past 5,000 years prolific for changes to human genome

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

See also the three part series that recapitulates everything I have exquisitely detailed in my published works during the past 23 years.
RNA Localization: Following Single mRNAs from Birth to Death in Living Cells (2018)
Others may continue their attempts to make it appear that human evolution has occurred during much longer periods of time, but their ridiculous claims are not supported by any experimental evidence of top-down causation whatsoever.
The origin and adaptive evolution of domesticated populations of yeast from Far East Asia; Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk; and Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems have one thing in common. They link the creation of quantized energy to light-activated microRNA biogenesis and biophysically constrained viral latency. The EDAR V370A variants in the mouse to human model of ecological adaptations link changes in one base pair to fixation of one amino acid substitution that stabilizes the organized genomes of mice and humans in the context of the stability of organized genomes in yeasts.

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