Info Wars: From hate-monger PZ Myers to Kevin J. Mitchell

By: James V. Kohl | Published on: August 23, 2018

The spurious claim that microRNAs evolved independently ignores all the facts that link natural selection for quantized energy-dependent codon optimality from differences in RNA sequencing and differences in transcriptome assembly to differences in the amino acid sequence of genes.
Summary of Info Wars: Hate-monger PZ Myers on the Origin of Life (3)

 …any type of atom can have various numbers of electrons or neutrons, [but] the number of protons predicts behavior unfailingly when the behavior is linked from the creation of photons to proton gradients and biophysically constrained viral latency in the context of light-activated microRNA biogenesis and autophagy.

See for comparison: Does Neuroscience Leave Room for Free Will? by Kevin Mitchell

I argue here that physical indeterminacy provides room for the information entailed in patterns of neuronal firing – the mental content of beliefs, goals, and intentions – to have real causal power in decision-making.

Serious scientists have answered all questions about free will by providing experimental evidence that links differences in the energy of photons to behavior via integration of what’s known into game play for ages 10+.
See: Subatomic
Moving forward to a stifled attempt to discuss the link from physics, chemistry and biology to geological age, we have New geological age comes under fire

 “…we are living in a new geological age… based on signs in the rock record of a global drought that began about 4200 years ago.”

Debate must wait a decade because the International Commission on Stratigraphy (ICS), the bureaucracy that governs geological time, and Facebook limit debates to prevent the horrors of censorship from being exposed.
See for example: Virus-mediated archaeal hecatomb in the deep seafloor
If debate about geological age was permitted, only pseudoscientists would refuse to acknowledge “…the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems.” The pseudoscientists do not like the fact that “…that virus-archaea interactions play a central role in global biogeochemical cycles.”
Scientific creationists have linked the virus-archaea interactions to the hecatombic evolution of all pathology during the same time they have linked light-activated microRNA biogenesis to biophysically constrained viral latency and healthy longevity via polycombic ecological adaptations.
For an example of the polycombic ecological adaptations, see:  Caste-, sex-, and age-dependent expression of immune-related genes in a Japanese subterranean termite, Reticulitermes speratus April 14, 2017

We found 197 immune-related genes (including 40 PRPs, 97 signalling proteins, 60 effectors) in R. speratus through a BLAST search querying amino acid sequences of these genes in various insect species (Table 1 and S1 Table).

These results will greatly contribute to a better understanding of the evolution of antimicrobial strategies, and the mechanism underlying longevity in termite reproductives.

Antimicrobial strategies are quantized energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction and sympatric speciation. The so-called strategies link the creation of endogenous substrates in all cell types from the immune system to pheromone-controlled reproduction and all biodiversity.
For another misrepresentation of cause and effect, see: Caste-specific microRNA expression in termites: insights into soldier differentiation

The finding that Isoptera and Hymenoptera shared several DE [differentially expressed light-activated differences in] miRNAs among castes suggests that these miRNAs evolved independently in these phylogenetically distinct lineages.

The spurious claim that microRNAs evolved independently ignores all the facts that link natural selection for quantized energy-dependent codon optimality from differences in RNA sequencing and differences in transcriptome assembly to differences in the amino acid sequence of genes.
See also: Expression of key components of the RNAi machinery are suppressed in Apis mellifera that suffer a high virus infection (2017)
For a historical perspective, see: MicroRNAs in Honey Bee Caste Determination (2016) and my 2013 refutation of all neo-Darwinian pseudoscientific nonsense Nutrient-dependent/pheromone-controlled adaptive evolution: a model

The honeybee model organism exemplifies what has been learned from the study of invertebrates (De Loof, Lindemans, Liu, De Groef, & Schoofs, ). This includes what has been learned about the epigenetic effects of nutrients and pheromones on juvenile hormone (JH). However, the molecular biology of cause and effect that is common to all species was left behind, and the epigenetic effects of human pheromones have not typically been considered in the same context as epigenetic effects of food odors and insect pheromones or the epigenetic effects of pheromones on other mammals.

The epigenetic effects of nutrients and pheromones extend across the life history of organisms, but from 1996 to 2012 the concept of molecular epigenetics and epigenetic effects on hormone-driven adaptive evolution of the human brain and behavior seems to have gone missing.

Pseudoscientists continued to link all caste-, sex-, and age-dependent expression of immune-related genes from the evolution of the innate immune system to all biodiversity despite the fact that all serious scientists know that all biodiversity is biophysically constrained by what organisms eat and the physiology of pheromone-controlled reproduction in species from microbes to humans.
Kevin J. Mitchell’s forthcoming book “Innate: How the Wiring of Our Brains Shapes Who We Arewill no doubt place most of the pseudoscientific nonsense he has been touting for more than 2 decades into the context of what we detailed in our 1995/2002 publications of The Scent of Eros: Mysteries of Odor in Human Sexuality.
However, he will not bring anything new to the picture of global health, which can only be addressed in the context of how the creation of sunlight is linked from microRNA biogenesis to biophysically constrained viral latency.
For example, search inside his book for “virus” and for “pheromone” before wasting any more time or money on his pseudoscientific nonsense. Add searches for “mutation” and “evolution” if you are not convinced that Kevin J. Mitchell is nothing more than another biologically uninformed theorist, who has failed to grasp what is known to serious scientists about RNA interference, see this New complimentary webinar from Science: The power of RNA: Broad application of RNA-based sequencing for transcriptome and genome analysis

Over the past decade, RNA-based sequencing has become the standard method for analyzing differential messenger RNA (mRNA) expression and for detecting both novel transcripts and allele-specific expression, as well as for identifying pre-mRNA intron–exon splice junctions. This versatile technique has been used extensively to analyze the whole transcriptome and is frequently combined with mRNA capture or ribosomal RNA depletion to enable more detailed analysis across the broad range of expression levels. In some studies, novel RNA-based approaches provide research answers that cannot be revealed by conventional DNA-sequencing approaches.

Re: …identifying pre-mRNA intron–exon splice junctions…

See: From Fertilization to Adult Sexual Behavior

The ability to identify the pre-mRNA intron–exon splice junctions takes us back to 1996, when (in our section on molecular epigenetics) we wrote:

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.


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