Energy-dependent ‘futile cycles’ of autophagy

By: James V. Kohl | Published on: September 14, 2018

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Quantized energy from virucidal sunlight protects the cell types of all living genera from the degradation of messenger RNA that links mutations to pathology. That fact was placed into the context of what is known about seemingly futile cycles that link circadian rhythms from quantum physics to quantum souls via feedback loops that link olfaction and pheromones to the physiology of reproduction.
Mating Pheromone in Cryptococcus neoformans Is Regulated by a Transcriptional/Degradative “Futile” Cycle (2010)

…paradigms from more conventional substrate cycles suggest that both induction and degradation are important mechanisms of regulation during changes from repressive to inductive conditions.

Allelic exchange of pheromones and their receptors reprograms sexual identity in Cryptococcus neoformans (2010)

These data reveal that cell identity in C. neoformans is controlled fully by three kinds of MAT-encoded proteins: pheromones, pheromone receptors, and homeodomain proteins. Our findings establish the mechanisms for maintenance of distinct cell types and subsequent developmental behaviors…

The fact that pheromones biophysically constrain viral latency in species from microbes to humans was revealed in the context of the mouse model of cell type differentiation.
[Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] (1994)

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

Two magnificent displays of human idiocy have since been exposed in the words of Jay R. Feierman and Markus Ralser.
Jay R. Feierman;

Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.

Markus Ralser:

…supercoiled DNA structure does not predict metabolite levels, nor does anti-viral latency, nor light induced miRNAs

See for comparison:

See also:

Most people do not realize what’s at stake in this paradigm shift that first linked energy-dependent changes from atoms to ecosystems in this invited review of nutritional epigenetics that was returned without review in 2014: See: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems
I resubmitted it when I was again asked for an invited review, and published it as: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems
The microRNA-mediated links from angstroms to ecosystems became clearer in December (2014).

See for comparison: Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts (2018)
The spurious claim about evolved underlying chemistry and topological organization of metabolism is cause for alarm because it links the comment by Jay R. Feierman to the comment by Markus Ralser.
They are among the biologically uninformed theorists who refuse to accept the facts that link quantized energy to all biophysically constrained biodiversity via microRNA biogenesis and autophagy, which means they will continue to contribute to the unnecessary suffering and premature death of those who could be saved by others who have stayed current with the extant literature.