Emergence of a coherent model

By: James V. Kohl | Published on: October 4, 2018

Transcription drives DNA replication initiation and termination in human cells

…although origins have been observed via several independent techniques to be enriched close to transcribed genes and a range of other chromatin features (Besnard et al., 2012; Dellino et al., 2013; Langley et al., 2016; Petryk et al., 2016), a coherent model that encompasses both origin specification and activation has not emerged.

Transcription and termination are energy-dependent. The energy is contained in food and the pheromone-controlled physiology of reproduction biophysically constrains viral latency.
Feedback loops link odor and pheromone signaling with reproduction (2005)
Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013)
Endogenous RNAi Pathways Are Required in Neurons for Dauer Formation in Caenorhabditis elegans (2017)

…RNAi pathways may mediate distinct effects on gene expression in postdauer animals that experienced different environmental stresses. Since other animals, such as pea aphids, form polyphenisms due to crowding or starvation as well, we predict that this work may have broader implications for the RNAi-mediated regulation phenotypic plasticity.

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage (2018)

We identify shared active transcription factor binding regions in the reprogrammed prostate and lung SCNCs by integrative analyses of epigenetic and transcriptional landscapes.

Reported as: Researchers discover aggressive prostate and lung cancers are driven by common mechanisms

“Our study revealed shared ‘master gene regulators’—the key proteins that control expression of multiple genes in small cell cancer cells,” Witte said.

Proteins do not control the expression of multiple genes. All gene expression is energy-dependent and occurs downstream from microRNA biogenesis. More than 78,000 published works that are indexed on PubMed attest to that fact and ~1000 new publications have been added during each of the past  20 months.

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