Catch 22: Democrats lose it all (2)

Democrats lost their grip on reality in the context of their greed and attempts to support the money-making pseudoscientists who have failed to make scientific progress towards the effective treatment or prevention of all pathology.

See for example:

https://www.facebook.com/Johns.Hopkins.Medicine/videos/10155074214404194/

For comparison to mathematical models and “bad luck” hypotheses, the link from light-activated microRNA biogenesis and biophysically constrained viral latency to diet-driven healthy longevity would be clear — if not for the pseudoscientific nonsense touted by people like Carl Zimmer in articles like “Deep in Human DNA, a Gift From the Neanderthals”

He declares

“People of Asian and European descent — almost anyone with origins outside of Africa — have inherited a sliver of DNA from some unusual ancestors: the Neanderthals.”

For comparison to what he calls “a sliver of DNA,” the EDAR V370A substitution links the mouse to human model of food energy-dependent pheromone-controlled ecological adaption to human populations in North and East Asia and in the New World.

See: “Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk”

“The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.”

I placed the eternal significance of light-activated microRNA biogenesis into the context of links across species and kingdoms to the EDAR V370A allele in human populations in my 2014 invited review of nutritional epigenetics, which was published as: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)

See the cited works:

159. Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, et al. (2013) Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell 152: 691-702.
160. Grossman SR, Andersen KG, Shlyakhter I, Tabrizi S, Winnicki S, et al. (2013) Identifying recent adaptations in large-scale genomic data. Cell 152: 703-713.

See for comparison the bastardization of everything known about light-activated microRNA biogenesis, ecological adaptations, and recent changes to the organized human genome in:

Evidence that RNA Viruses Drove Adaptive Introgression between Neanderthals and Modern Humans (senior author, Dmitri Petrov)

The evidence is confusing because it fails to link what organisms eat from the physiology of reproduction to the “adaptive introgression” via sympatric speciation. When evolutionary biologists place their findings back into ridiculous neo-Darwinian theories, they challenge the Trump administration to continue to drain the academic swamp. The process started with damning the scientific credibility of Christine Blasey Ford’s  60+ published works and can now continue with examples of the lack of credibility in the articles published by Dmitri Petrov’s group. Christine Blasey Ford and Dmitri Petrov are Stanford-based “so-called” experts.

For comparison, see: Fisetin is a senotherapeutic that extends health and lifespan

Reported as: Researchers have discovered how to slow aging

Natural product found to reduce the level of damaged cells in the body, caused by aging

See also:RNA-Guided Human Genome Engineering 

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

The patent for naturally occurring food energy-dependent RNA-mediated DNA damage repair was placed into the context of this “billion dollar baby,”

Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy

Only the billionaires can afford the therapy, which helps to explain why politicians on both sides of the controversy surrounding the elevation of Judge Kavanaugh involved unsubstantiated allegations and character assassination attempts.  The billionaires stand to lose billions if another unbiased Justice rules fairly on the legislation that is required to prevent the medical cost based bankruptcies of those who cannot afford to pay for medical insurance or the cost of treatments for any form of virus-driven pathology.

Also, for comparison to Carl Zimmer’s unadulterated pseudoscientific nonsense about evolution that he has touted during his entire career, see:  Therapeutic Oligonucleotides: State of the Art

Remember, the biggest threat to Homeland Security and to humanity is human idiocy. There may be no better example of that fact than Carl Zimmer.