CDC vs Who?
(click to enlarge)“Ryan Collins and others like him linked the difference between a mutation and an amino acid substitution to all food energy-dependent biodiversity on Earth via the physiology of reproduction, which allows only for the fixation of amino acid substitutions.” – Creation of an enzyme that kills theories (4)
See the web planner: PgmNr 95: Refining the map of genomic disorder loci and associated driver genes by integrating microarray data from 102,257 genomes and exome sequencing of 37,269 individuals.
See the predicted response to this long-overdue clarification. It was published in the New England Journal of Medicine and reported as: Nigeria’s largest Lassa fever outbreak sparked by rats: Analysis calms fears that the virus had mutated into a super-bug that could move more easily from person to person.
Pardis Sabeti attempted to calm the fears of theorists. They were afraid the latest uncontrolled outbreak had exposed their pseudoscientific nonsense about mutations and the evolution of viruses. Sabeti added to the fears of serious scientists, who are scared because they know that viruses do not mutate. Viruses adapt by stealing the energy that is required for cell type differentiation in species from microbes to humans.
For an example of adaptations in all living genera that have adapted to the viruses, see: Virus-mediated archaeal hecatomb in the deep seafloor
We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.
The central role that viruses play in global biogeochemical cycles can be placed into the context of this foolish statement about Nigeria’s largest Lassa fever outbreak.
“We are always preparing ourselves for the possibility that Lassa virus will pick up a mutation that lets it transmit readily from human to human,” Sabeti says.
The WHO will never be prepared for the next pandemic. They finally discovered what all serious scientists know about the Molecular requirements for a pandemic influenza virus: An acid-stable hemagglutinin protein and the Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events
The Multiple Interspecies Re-assortment Events clearly prevent preparation for the next viral pandemic. There is no way to learn more about where the ecologically adapted virus might come from. All extant marine bacteria, invertebrates, and all vertebrates have adapted to the viruses, but the viruses adapt too quickly. The next adaptation in an extremely virulent virus could cause the extinction of all human populations that cannot adapt quickly enough to the new threat.
For comparison, Pardis: “We are always preparing ourselves…” Sabeti, has a tractable history of ignorance.
But first, let me help to make the claims of Ryan Collins et al., perfectly clear. Viruses steal the energy that links amino acid substitutions to protection of organized genomes. The stolen energy is used to protect the structure and function of the virus from energy-dependent autophagy. Autophagy protects the supercoiled DNA of all organized genomes in individuals of every living species from the degradation of messenger RNA (mRNA). The degradation of mRNA links mutations to all pathology. For example, autophagy links the EDAR V370A allele to ecological adaptations in humans via the mouse-to-human model of biophysically constrained viral latency.
Sabeti placed that fact into the context of a link from the allele to human evolution in this title from 2013: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant
But, see this claim:
This work highlights the utility of modeling nonpathological human genetic variation in mice, providing a framework for assessing other candidate adaptive human alleles.
Food energy-dependent adaptive human alleles are not mutations and adaptations are not linked to mutation-driven evolution. How can anyone in her position be that horribly confused? See hos her confusion alters the perspective of others who are confused. Everyone in this representation of her nonsense is confused. Are you?
From February 14, 2013. At 2:00 minutes, Kristian J. Andersen revealed the fact that he did not know the difference between an amino acid change and a mutation in the Toll-like receptor, TLR5 .
See: Toll-like receptor TLR5 microRNA
Effect of Low-Fat Diet in Obese Mice Lacking Toll-like Receptors (2018)
The link from microRNA biogenesis to the food energy-dependent pheromone-controlled physiology of reproduction predicted that TLR signaling would link the EDAR V370A allele from the mouse model organism to ecological adaptations in humans. That fact predicted that theorists would try to obfuscate what is known about the EDAR V370A, which is also referred to as 370A, Val370Ala, 1540T/C and as rs3827760— a single nucleotide polymorphism (SNP) in the ectodysplasin A receptor EDAR gene on chromosome 2.
A SNP is a variation in a single base pair in a DNA sequence. Sabeti’s group used the 370A designation to link one food-energy-dependent change in one base pair change (i.e., the single nucleotide polymorphism) to the stability of nonpathological human genetic variation via the pheromone-controlled creation of the ectodysplasin A receptor EDAR gene.
Receptor genes, as all serious scientists know, do not create themselves. They are created in the context of energy linked to food odors and pheromones.
Enter the confusion of pseudoscientists and biologically uninformed theorists. Sabeti’s group placed everything known to serious scientists about food energy-dependent biophysically constrained base pair changes, biophysically constrained viral latency, and cell type differentiation back into the ridiculous context of mutation-driven evolution.
Sabeti appears to be committed to the ongoing misrepresentation of facts. I repeat: The WHO will never be prepared for the next pandemic. (Kohl, 2018)
See for comparison: Pandemics: spend on surveillance, not prediction.
Edward C. Holmes, Andrew Rambaut and Kristian G. Andersen, claimed that “Trust is undermined when scientists make overblown promises about disease prevention.”
All serious scientists know that natural selection for food energy-dependent codon optimality links RNA-mediated DNA repair from autophagy to biophysically constrained viral latency.
For an accurate extension of Sabeti’s works, see: Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations.
Differences in the diet of different human populations were reported as: Diet affects the breast microbiome in mammals
Sabeti’s misrepresentation of the WHO’s preparedness can be linked to this claim:
We showed for the first time that breast-specific microbiome populations are significantly affected by diet…
See also: Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements
Reported on 10/18/18 as: Breastfeeding protects infants from antibiotic-resistant bacteria
“Babies inherit every facet of antibiotic misuse since the discovery of antibiotics,” notes Pärnänen.
Who else besides Pardis Sabeti failed to link WHO’s lack of preparedness to the facts about Feedback loops link odor and pheromone signaling with reproduction?
See for comparison: Kalevi Kull: Censorship & Royal Society Evo Event
Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull
After I began to show Sabeti where she had gone wrong in a series of “Tweets” (President Donald Trump’s way to move forward), she blocked me from seeing the nonsense she kept touting.
For comparison, see: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk
The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.
Others still tout the nonsense of human evolution over 20, 000 years, but fewer people are willing to make such ridiculous claims now that the transgenerational epigenetic inheritance of tissue-type specific changes in microRNA biogenesis has been linked to populations in North and East Asia and the New World by one SNP and fixation of one amino acid substitution in the organized genomes of human populations in the Old World and in the New World.
All serious scientists know that only one food energy-dependent biophysically constrained amino acid substitution is required to protect organized genome from the virus-driven degradation of messenger RNA. Why are theorists still telling us about mutations and evolution?
