Adding new terms for confusion
Summary: Amino acid repeats are food energy-dependent and pheromone-controlled in species from microbes to humans. They link the creation of sunlight from subatomic particles in amino acid pi clouds to consciousness via microRNA biogenesis and the effects of anesthesia in flies and in octopuses.
The tipping point (revisited): 80,000 publications
In my February 2017 virtual conference presentation on Precision Medicine, I reported these recent additions to the Merriam-Webster dictionary:
phytoremediation, microbiome, CRISPR.
Some people claimed that the words I use are meaningless or “jargon.” I linked phototaxis, thermotaxis, pH taxis and chemotaxis in the context of Energy as information and constrained endogenous RNA interference
Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy. The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.
This detailed representation of energy-dependent natural selection for codon optimality links biologically-based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.
For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes.
Genomic complementary DNAs, nonhomologous end-joining, and retroelement invasion hypothesis are new terms that have since been added for confusion.
What can be said about researchers whose use of invented terms seems to be intended to obfuscate the facts that link light-activated microRNA biogenesis to biophysically constrained viral latency and all biodiversity?
See: MicroRNA-451a overexpression induces accelerated neuronal differentiation of Ntera2/D1 cells and ablation affects neurogenesis in microRNA-451a-/- mice
…these results provide strong support for a role of miR-451a in neuronal maturation processes in vitro and in vivo.
The authors cite: POU3F2 participates in cognitive function and adult hippocampal neurogenesis via mammalian-characteristic amino acid repeats
Taken together, these results suggest that POU3F2 is involved in cognitive function as well as adult hippocampal neurogenesis, and that homopolymeric amino acid repeats in this gene play a functional role.
The amino acid repeats are food energy-dependent and pheromone-controlled in species from microbes to humans. They link the creation of sunlight from subatomic particles in amino acid pi clouds to consciousness via microRNA biogenesis and the effects of anesthesia in flies and in octopuses.
See for comparison: Innate How the Wiring of Our Brains Shapes Who We Are
MY REVIEW Ignoring light-activated microRNA biogenesis
He frames his claims in the context of random mutations and evolved biodiversity despite the facts that serious scientists have detailed. For example, ages 10+ can learn how the creation of subatomic particles must be linked from cytosis to biophysically constrained viral latency and sympatric speciation.
The physiology of reproduction is linked to heredity in species from soil bacteria to humans via EDAR V370A (an amino acid substitution) in mice; in populations found in North and East Asia; and in populations in the New World.
I could go on about the facts about cell type differentiation for hours or refer you to MicroRNA.pro or one of my other domains. Alternatively, you could see the work that was published today: “MicroRNAs buffer genetic variation at specific temperatures during embryonic development” for comparison to our 1996 review of molecular epigenetics: “From Fertilization to Adult Sexual Behavior”
Endorsements (by biologically uninformed theorists):
“Nature versus nurture is a centuries’ old distinction, but neuroscience and genetics are taking us to a new level of sophistication in understanding it. We are going beyond the realization that nature and nurture are inextricable, and are now gaining insights about what nature contributes and how it makes nurture possible. Mitchell’s book is a new landmark in this debate, with clear and substantive explanations of the new light that biology is shedding on an old question.”—Steven Pinker, Johnstone Professor of Psychology, Harvard University, and author of The Blank Slate and Enlightenment Now
“What makes you you? Are there genes for intelligence or sexuality? How much is your personality determined by genes and how much by environment? In Innate, leading geneticist Kevin Mitchell takes us on a fascinating journey into the science of nature and nurture, in health as well as in neurodevelopmental conditions such as autism and schizophrenia. It is a captivating read, and relevant to all of us.”—Sarah-Jayne Blakemore, author of Inventing Ourselves: The Secret Life of the Teenage Brain
“What makes people differ from one another, and how much does biology have to do with it? Kevin Mitchell bravely wades into some of the most politically fraught questions in science and delivers a clear, level-headed, up-to-the-minute account of what we do and don’t know.”—Gary Marcus, author of Guitar Zero and The Birth of the Mind
“Innate is outstanding in every respect—timely, important, and unlike any other book. Kevin Mitchell is at the very top of his field, and he writes with exceptional clarity, using compelling and memorable examples. His stellar contribution on ‘noise’ during embryonic and later development will utterly change how many people think about individual differences and the role of genes. Innate is a flat-out winner.”—Patricia S. Churchland, author of Touching a Nerve: Our Brains, Our Selves
“Lucid and refreshing, Innate cuts through the Gordian knot of confusion about nature and nurture and heralds a sea change in psychology and neuroscience research and in the public’s engagement with it. Kevin Mitchell explains the fundamental role of genetic factors in brain and mind development in a clear and compelling way. This is a truly important book.”—Uta Frith, author of Autism: A Very Short Introduction
