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By: James V. Kohl | Published on: December 6, 2018

Summary: John Hewitt links de Vries definition of mutation (i.e., sudden energy jumps) to all biodiversity.  I claim that food energy is required to biophysically constrain the virus-driven degradati0n of messenger RNA. Only if, in theory, food energy emerges from the void as did the energy from the “Big Bang,” can a “deuterium switch” automagically be linked to the understanding of how receptors work.  If energy is required to create the receptors, the energy can be linked from  the light-powered bacterial ion pump to the creation of GPCRs.
Using the ‘deuterium switch’ to understand how receptors work (2016)

John Hewitt claims that G protein-coupled receptors (GPCRs) are frequently considered to be a predominantly Eukaryotic innovation.  Supposedly, “…bacteria generally go for more direct-acting receptors with efficient built-in ion channels…”

He uses rhodopsin as an example of ‘seven transmembrane domain’ family of proteins, which are called GPCRs for comparison to the ancient light-powered bacterial ion pump.

That suggests that from the beginning of evolution the light-powered bacterial ion pump started to become more like a GPCR.
In my model of biophysically constrained viral latency, light-activated microRNA biogenesis is required to link the light-powered bacterial ion pump to the creation of GPCRs and to morphology and behavior across the time-space continuum. The sense of smell in bacteria has been linked to our visual perception of energy and mass.
See: Olfaction Warps Visual Time Perception (2018)
See also: Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs (2017)

As mammals produce Dicer-dependent viral siRNAs to target RNA viruses, our findings suggest a possible role for mammalian RLRs and interferon signaling in the biogenesis of viral siRNAs.

In my model, the link from the light-powered bacterial ion pump of bacteria to the immune system of nematodes and the GPCRs that appear to protect mammals from the virus-driven degradation of messenger RNA extends across the time-space continuum of nutrient-dependent pheromone-controlled biodiversity in species from yeasts to primates.
See for example our section on molecular epigenetics in From Fertilization to Adult Sexual Behavior (1996)
We discuss upstream and downstream genes that are likely also to play crucial roles in the context of top-down food energy-dependent causation that links multigene interrelationships to profound impacts upon morphological phenotypes and behaviors. We add this for shock value and because it’s true.

Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus (Runge and Zakian, 1996; Wu and Haber, 1995).

More than 20 years later, I see no indication that John Hewitt has learned anything about biophysical constraints on food energy-dependent RNA-mediated cell type differentiation. For comparison, in 2016 he made claims about Type V receptors, which supposedly tunnel electrons across a gap that corresponds to an energy jump in the context of vibrations at the correct energy for comparison to Type T receptors that share the same circuit topology but exhibit no energy jump.
When I questioned his use of de Vries definition of mutation (a sudden energy jump), John Hewitt blocked me from further comments on social media and failed to respond to my comments on Disqus.
I wrote:

Naturally occurring RNA interference has been patented as RNA-Guided Human Genome Engineering. Biophysically constrained viral latency at the level of quantum physics (energy-dependent changes in base pairs) is the link to sympatric speciation. That fact is exemplified by the diet-driven changes from C. elegans to the predatory nematode P. pacificus. The virus-driven degradation of messenger RNA forces diet-driven adaptations in P. pacificus, which include “teeth.” Changes in behavior are linked to its acquired ability to eat other nematodes.

I’ve had co-workers that I knew would adapt their behavior so that they could eat me if they got hungry enough. Congresswoman Alexandria Ocasio-Cortez will probably use the nematode model from her 2007 award-winning poster session to show that the nonsense about gene-editing was nothing more than another money making scam that paid well or fed everyone involved, mostly other Democrats in the USA.

She will force the change to less expensive and more effective treatments with RNA interference in the context of what has been referred to as a “billion dollar baby,” Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy

(aka John Hewitt) wrote:

Might this platform or something similar be used to edit mitochondria?
Could one make use of phase specific information, strand differences or SNPs at specific locations so that only one chromosome is targeted, presumable an offending heterozygous allele?

Food energy is something similar. It is already used to naturally edit mitochondria in the context of natural selection for energy-dependent codon optimality via RNA interference. The creation of ATP links the creation of RNA from RNA interference to fixation of amino acid substitutions and supercoiled DNA via the physiology of reproduction, which biophysically constrains viral latency. The pathways have been detailed at every level of examination from subatomic particles and cytosis to autophagy and healthy longevity.
(aka John Hewitt) wrote:

I would have put the brakes on there at the end of sentence number 2 my man, or at least at supercoiled, and definitely by latency.

I’ve dealt with his level of ignorance before and he knows I do not care where he would put the brakes on. I think he wants me to put the brakes on so that he can start moving again with a sudden energy jump that links mutations to evolution. So, I wrote:

You are a theorist who has stalled scientific progress with claims of mutation-driven evolution based on deVries definition of mutations as sudden energy jumps. All serious scientists know that gene expression is energy-dependent, and they know the energy comes from the sun. Sunlight is required to grow food, get it?

Two games for ages 10+ support my claims, which link energy-dependent changes in angstroms to ecosystems via biophysically constrained viral latency in supercoiled DNA.

It is only a matter of time until other science journalists expose the pseudoscientific nonsense touted by you as John Hewitt in: “Using the ‘deuterium switch’ to understand how receptors work”…

Keep playing your hit and run game game here as “Mitochondrion” until others realize why you must block me from seeing your posts elsewhere. Simply put, you are an incompetent science journalist with less understanding of biology than most 10-years olds.

See: “A comparison of gene expression and DNA methylation patterns across tissues and species”…

My follow-up:

John Hewitt (Mitochondrion) and others like him want to prevent others from learning the facts about ecological adaptations.

See for comparison: Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia (12/3/18) and HHV-6 encoded small non-coding RNAs define an intermediate and early stage in viral reactivation (9/5/18), which was reported as: Viruses under the microscope…

“The virus hides in the genomic DNA”

Energy-dependent biophysical constraints on supercoiled DNA typically ensure viral latency by preventing stress-linked viral activation. Facts about human endogenous retroviruses (HERVs) have been linked to the viruses that supposedly hide in the organized genomes of other species for more than 2 decades. Reports that claim viruses hide are anthropocentric and gene-centric. They are among the most foolish of all reports published by biologically uninformed theorists and reported by so-called “science journalists.”

I do not expect any more discussion about the fact that CRISPR is Going to be Replaced. Few people seem to know enough about biophysically constrained cell type differentiation to understand that it is energy-dependent. By starting with mutations (de Vries, sudden energy jumps) they miss the facts about the virus-driven degradation of messenger RNA that links mutations to all pathology.
Having been caught touting ridiculous theories that still are based on a definition from the turn of the 20th century, people like John Hewitt must duck and run for cover, as serious scientists continue to detail cause and effect.
See for example, A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis (2017)

Our results uncover a role for this viral Sm-class RNA as a microRNA adaptor in the regulation of gene expression that follows precursor mRNA processing.

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