The tipping point (revisited): 82,000 publications (5)

By: James V. Kohl | Published on: January 17, 2019

Presentations during Mind Mood Microbes 2019 #mmm2019 seem to lack information on how stress-linked reactivation of viruses is linked from the degradation of messenger RNA to all pathology.
For comparison see this Summary:
Light-activated microRNA biogenesis in plants links positive selection for food and the physiology of reproduction in the gut bacteria human populations from the Old World to the New World via and biophysically constrained viral latency in species from microbes to humans. Social interaction-induced activation of RNA splicing has been linked to differences in morphological and behavioral phenotypes for more than 2 decades.
Extensive unexplored human microbiome diversity revealed by over 150,000 genomes from metagenomes spanning age, geography, and lifestyle was reported on 1/17/19
That requires reevaluation of what is know about energy-dependent biophysical constraints on cell type differentiation and behavior in all living genera.
See: Enduring Effects of Muscarinic Receptor Activation on Adult Hippocampal Neurogenesis, MicroRNA expression and Behaviour 1/13/19
John Cryan’s group has linked light-activated microRNA biogenesis in plants from low-dose stimulation of the cholinergic system and microRNA-mediated cell type differentiation in the brain to behavior in rats. He is a 2017 Nobel Laureate (Physiology and Medicine).
See also: 12/13/18

See also: Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice (2018)
We linked alternative splicing of pre-mRNAs, which are now known as microRNAs, to behavior in species from yeasts to mammals in From Fertilization to Adult Sexual Behavior (1996) Cryan’s group did the same thing 22 years later via differences in the food energy-dependent production of pheromones to behavior in the context of alternative RNA splicings in mice.
His claims are consistent with everything known about the energy-dependent  Structural diversity of supercoiled DNA
Simply put, it’s All About That Base

See also: The symmetrical pattern of base-pair substitutions rates across the chromosome in Escherichia coli has multiple causes

…rates of base-pair substitutions (BPSs) vary 2- to 4- fold in a wave like pattern that is mirrored in the two independently replicating halves of the chromosome.

Based on a published work by Patricia L. Foster (2000) Adaptive mutation: implications for evolution, it appears that her students have made no further progress towards understanding the link from light-activated changes in base pairs and natural information processing in bacteria to the physiology of pheromone controlled reproduction that links sympatric speciation from biophysically constrained viral latency to all extant biodiversity via food energy-dependent fixation of RNA-mediated amino acid substitutions, supercoiled DNA, and chromosomal rearrangements.
I recommend that the authors and all theorists review the extant literature and try to explain their findings in the context of Learning from Bacteria about Natural Information Processing and Stability of the hybrid epithelial/mesenchymal phenotype
It seems likely that rates of base-pair substitutions (BPSs) vary in a wave-like pattern linked to two independently replicating halves of the chromosome because that is required to link light-activated energy-dependent changes from quantum physics to classical physics and the chemistry of biophysically constrained protein folding, which is manifested in species from microbes to humans.
See also: Extensive Unexplored Human Microbiome Diversity Revealed by Over 150,000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle (2019)
This takes nutrient-dependent pheromone-controlled physiology of reproduction to a new level at which sympatric speciation can be examined in the context of biophysically constrained viral latency rather than theories about mutations and evolution.
For an example of biophyscially contrained viral latency that extends across age, geography, lifestyle in human population in the Old World to the New World, see:  open Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

The 20,000 year ago estimate is not consistent with this report of changes in organized genomes that have been linked to pathology more recently.
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
Reported as: Past 5,000 years prolific for changes to human genome

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

See also: Superficial layers suppress the deep layers to fine tune cortical coding 1/16/19

We employed cell-type specific optogenetics to test the functional relationship between layer 2/3 and layer 5. Surprisingly, we discovered that L2/3 primarily suppresses cortical output from L5. The recruitment of somatostatin positive interneurons is likely fundamental to this relationship. The net effect of this translaminar suppression is to enhance the selectivity and expand the range of receptive fields, therefore potentially sharpening the perception of space.

Photoactive fine-tuning of sensory perception was previously reported in the context of how the creation of the sense of smell in bacteria was linked to our visual perception of energy and mass via the physiology of pheromone-controlled reproduction and the time-space continuum.
See: Olfaction Warps Visual Time Perception link opens pdf

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