RNA processing and disease (3)

By: James V. Kohl | Published on: February 22, 2019

Evolution and the ice age 2/26/13

Scientists are discovering how the evolution of ecosystems has to be taken into account when speculating between different geological eras. Go back to the time of the dinosaurs or to the single-celled organisms at the origins of life, and it is obvious that ecosystems existing more than 65 million years ago and around four billion years ago cannot be simply surmised from those of today.

That is because no experimental evidence suggests any ecosystem has “evolved” during any geographical era. The evolution of ecosystems occurs only in the statistical analysis of biologically uninformed theorists.
For comparison, see: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk (4/23/18)
The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.
The frequency of the EDAR V370A allele links the mouse-to-human model of nutrient-dependent pheromone-controlled ecological adaptations to biophysically constrained viral latency in species from microbes to humans.
Did I mention: Symbiotic organs shaped by distinct modes of genome evolution in cephalopods
We report distinct evolutionary signatures within the two symbiotic organs of E. scolopes, the light organ (LO) and the accessory nidamental gland (ANG).

As I recall, on 2/21/19 I wrote: The idea that two organs in one organism simultaneously evolved may be the most ridiculous example of neo-Darwinian pseudosceintific nonsense that the world will ever see.
Was I wrong? Today I read: New Squid Genome Shines Light on Symbiotic Evolution 2/19/19

…by understanding how squids communicate with their bacteria in these different environments, researchers may eventually come to understand the basis of some of these immune diseases, he said.

Who does not understand: How Complex Wholes Emerge From Simple Parts

…emergence has its critics, who find it too slippery and too uninformative to be useful.

Clearly, the simultaneous emergence of two organs in the same organism defies the common sense approach to food energy-dependent pheromone-controlled ecological adaptations in the Octopus.
See: Role of olfaction in Octopus vulgaris reproduction

The OL acting as control centre may be target organ for metabolic hormones such as leptin like and insulin like peptides, and olfactory organ could exert regulatory action on the OL via epigenetic effects of nutrients and pheromones on gene expression (Kohl, 2013; Elekonich and Robinson, 2000).

Kohl (2013) Nutrient-dependent/pheromone-controlled adaptive evolution: a model
Elekonich and Robinson (2000) Organizational and activational effects of hormones on insect behavior
Elekonich and Robinson (2000) cites: Diamond, Binstock and Kohl (1996)

“The development of species-typical and sex-specific adult behaviors in vertebrate animals is influenced by gonadal steroid hormones, non-gonadal hormones, and non-hormonal factors working on the underlying neural circuitry (reviewed in Diamond et al., 1996; Kawata, 1995; Schlinger, 1998).”

Diamond et al. (1996) is our Hormones and Behavior review of RNA-mediated cell type differentiation in species from yeasts to mammals:  From Fertilization to Adult Sexual Behavior
It led to publication of Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (4/18/18)

See for comparison: Genetic Variability among Presumed Clonal Pathotypes of Puccinia graminis f. sp. tritici in Australia 6/18/18

“…pathogenicity and environmental adaptation of these fungi…” are compared to “..pathotype genetic variations [that] originate from the different forms and rates of mutation which vary per locus.”

Of course many people do not understand what this means in the context of pathogenicity compared to adaptations. Most cannot link it to the forthcoming cure for cancer and all other diseases, but serious scientists have done that for you.

They asked “What’s an amino acid?” Every serious scientist has since detailed the difference between the energy-dependent effects of fixed amino acid substitutions, such as EDAR V370A on healthy longevity, for comparison to the virus-driven degradation of messenger RNA that link mutations to all diseases.

See also: Combating Evolution to Fight Disease 3/7/14

Molecular biology and evolutionary biology have been separate disciplines and scientific cultures: The former is mechanistic and focused on molecules; the latter is theoretical and focused on populations. However, these domains are beginning to converge in laboratories addressing molecular mechanisms that explain how evolutionary processes work, and bring these processes to bear on medical problems such as cancer and infectious disease. Each discipline can be viewed as a missing link in the other’s description of biology, and in medicine.

The war cry is adapt or die, not mutate and evolve! The adaptations occur only in the context of the light-activated assembly of the microRNA-ribonucleic acid-peptide nanocomplex, which biophysically constrains viral latency in species from microbes to humans.

But first, you must accept the fact that sunlight is the source of all energy and biodiversity on Earth.

Eukaryotic plankton diversity in the sunlit ocean (2015)

Virus-mediated archaeal hecatomb in the deep seafloor(2016)

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