Preprints obfuscate facts (3)

By: James V. Kohl | Published on: February 26, 2019

See: Preprints obfuscate facts (1) from and Preprints obfuscate facts (2) from
Photoperiod-dependent expression of MicroRNA in Drosophila (11/6/18) is one of 2173 search results for “microRNA” at @biorxivpreprints. All results can be compared to >83,500 published works from this PubMed search for microRNA
The PubMed search links the energy-dependent creation of achiral glycine, the only achiral amino acid, from Alpha protons as NMR probes in deuterated proteins (2/14/19) to gene regulatory signatures of ecological adaptations via  Stress-responsive miRNAome of Glycine max (L.) Merrill: molecular insights and way forward (2/23/19), which cites: Plant miRNAome and antiviral resistance: a retrospective view and prospective challenges (2014).
The retrospective view of microRNA-mediated antiviral resistance includes this fact:

…the gene silencing attribute of miRNAs has been ingeniously manipulated to down-regulate the expression of any gene of interest, including VSRs, in artificial miRNA (amiRNA)-based transgenics.

Down-regulation of genes of interest via energy-dependent microRNA-mediated fixation of amino acid substitutions in cell types of all cells in all individuals of all living genera is the key to the reported cure for cancer. For comparison, the challenge is to get theorists to stop touting pseudoscientific nonsense and start with light-activated microRNA biogenesis in the context of the energy-dependent creation of ATP and the creation of RNA reported by McEwen et. al., (1964) in Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See also: Analysis of 5′ gene regions reveals extraordinary conservation of novel non-coding sequences in a wide range of animals (2015)

We report the identification of the most deeply conserved CNE’s found to date, and several other deeply conserved elements which are without exception, part of 5’ untranslated regions of transcripts, and occur in a number of key translational regulatory genes, highlighting translational regulation of translational regulators as a conserved feature of insect genomes.

Eran Tauber is a co-author on Analysis of 5′ gene regions reveals extraordinary conservation of novel non-coding sequences in a wide range of animals (2015) and Photoperiod-dependent expression of MicroRNA in Drosophila (11/6/18)
The facts from the abstract of Alpha protons as NMR probes in deuterated proteins include information about how the enzyme L-Amino acid oxidase is linked to the labeling of the glycine methylene carbon via a single deuteron, which allows the stereospecific assignment of glycine alpha protons. The creation of difference in the energy of two photons is thereby linked from the proton motive force to the creation of ATP, enzymes, and the creation of all amino acids via two model systems for the construction of membrane proteins. Everything is linked from the light-activated creation of the microRNA-RNA-peptide nanocomplex to biophysically constrained viral latency and all biodiversity via sympatric speciation. There is no need to evoke the ridiculous context of mutation-driven evolution.  Theorists need only accept the fact that the applicability of the method to study membrane proteins links fixation of amino acid substitutions to biophysically constrained cell type stability via the potential of hydrogen (pH).
For comparison, see: A universal trend of amino acid gain and loss in protein evolution (2005)

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

Also 1,250 Results for the term “autophagy” could be linked to 1114 results from PubMed search for microRNA and autophagy for comparisons across species in the context of Light induced synaptic vesicle autophagy 10/11/18 and Efficient Near Infrared Light Triggered Nitric Oxide Release Nanocomposites for Sensitizing Mild Photothermal Therapy 12/11/18.
Nitric oxide release has  been placed into the context of Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation 2/21/19
This was reported as: New ‘interspecies communication’ strategy between gut bacteria and mammalian hosts uncovered, which attests to the fact that the regulation of microRNA machinery is food energy-dependent. Simply put they linked evidence from diet-driven changes in gut bacteria to the influence of pheromone-controlled physiology of reproduction in bacteria to healthy longevity in mammals via the conserved molecular mechanisms of energy-dependent autophagy in the context of everything known about how to link the creation of subatomic particles to cytosis and protection from the virus-driven degradation of messenger RNA that links mutations to all diseases.

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