Kohl and Francoeur at 25 (6)

By: James V. Kohl | Published on: April 3, 2019

Excerpt: Natural selection for energy-dependent codon optimality links what animals like to eat to biophysically constrained viral latency vira the physiology of their pheromone-controlled reproduction and transgenerational epigenetic inheritance of their morphological and behavioral phenotypes.
See for comparison: The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules
Reported as: ALS hope at last?

Since RNA molecules manage the expression of genes, intervening at the RNA level goes right to the apparent cause of that form of the disease, Disney says.

I reiterate. He said: “RNA molecules manage the expression of genes.”
Energy-dependent RNA interference has been linked to healthy longevity in all living genera. For comparison, the virus-driven degradation of messenger RNA has been linked from mutations to all diseases.
For example, light-activated microRNA biogenesis in plants links the energy-dependent biogenesis of all diversity from the physiology of pheromone-controlled reproduction in insects to mammals.
See: Interactions between plant genome size, nutrients and herbivory by rabbits, molluscs and insects on a temperate grassland
Reported as: Rabbits like to eat plants with lots of DNA
A revision of that pseudoscienitfic nonsense is required. Natural selection for energy-dependent codon optimality links what animals like to eat to biophysically constrained viral latency vira the physiology of their pheromone-controlled reproduction and transgenerational epigenetic inheritance of their morphological and behavioral phenotypes.
See also: Foliar-feeding insects acquire microbiomes from the soil rather than the host plant

…insect microbiomes… and… effects of plants on soil microbiomes can be transmitted to aboveground insects feeding later on other plants.

That claim exemplifies what is known about feedback loops. See: Feedback loops link odor and pheromone signaling with reproduction (2005)
See also: Interactive roles of chromatin regulation and circadian clock function in plants

The possibility that intergenomic interactions govern hybrid vigor through epigenetic changes at clock loci and the function of epialleles controlling clock output traits during crop domestication are also discussed.

This links changes in soil bacteria from crop diversification to the pheromone-controlled physiology of reproduction via diet-driven changes in exosome-linked diversity in primates.
See: Dietary diversity of an ecological and macronutritional generalist primate in a harsh high-latitude habitat, the Taihangshan macaque (Macaca mulatta tcheliensis)

…Taihangshan subspecies ( M. mulatta tcheliensis) in China… respond to ecologically constrained interannual variation in the macronutrient ratios of the spring diet in a way that theory predicts should be associated with ecological generalism.

Diet-driven ecological generalism in primates has been linked to the pheromone-controlled physiology of reproduction in all mammals.
See: Comperative chemical analysis of body odor in great apes
Major histocompatibility complex and mate choice in the polygynous primate: the Sichuan snub-nosed monkey (Rhinopithecus roxellana)
The authors cite: Kohl, Fink, Atzmueller, and Grammer (2001), but they claim:

…mate choice based on MHC-specific odors in our R. roxellana band is not supported in our present study group.

Something must have gone horribly wrong.
See: Genomic evidence for MHC disassortative mating in humans

Our findings support the hypothesis that the MHC influences mate choice in humans in a context-dependent way: MHC-driven preferences may exist in all populations but, in some populations, social constraints over mate choice may reduce the ability of individuals to rely on such biological cues when choosing their mates.

Similarly, Frans de Waal in ‘Mama’s Last Hug’ virtually ignored their claim that:

…there is a increasing evidence that scent associated with the production of pheromones produced by anogenital and axillary glands play an important role in primate endocrinology, reproductive behavior, and possibly mate choice (Laska & Seibt 2002; Heymann 2006; Clarke et al. 2009; Charpentier et al. 2008, 2010). This includes apes and humans (Shepherd 2004; Kohl et al. 2001; Wedekind & Penn 2000).

See also: The neglected sense-olfaction in primate behavior, ecology, and evolution (2006) This special issue emerged from a symposium held during the 20th Congress of the International Primatological Society in Torino, Italy, in August 2004. The symposium brought together scientists studying several different aspects of olfaction in primates.

It is also likely that olfaction plays a role in mate choice in humans, and mate choice may be influenced by properties of the MHC [Kohl et al., 2001; Wedekind & Penn, 2000]; however, these findings are controversial.

The difference between findings that are controversial and ignoring findings because they are controversial can be viewed in the context of: Hedge drift and advanced motte-and-bailey (2016)
On 3/25/19, the author claimed: You could say the same about any discussion of subtly misleading argumentation strategies. I think that history shows that openly discussing such strategies has been net positive. It’s not such an information hazard.
I responded: @WiringTheBrain and others like him know that their failure to discuss the link from light-activated microRNA biogenesis to biophysically constrained viral latency prevents others from learning that theorists are “not even wrong.” They are killing us all.
See: miRNA-based strategy for modulation of influenza A virus infection (6/11/18)

…we summarized various roles of miRNAs and exosomes in influenza A pathogenesis. Moreover, we highlighted therapeutic applications of miRNAs and exosomes in influenza.

The therapeutic applications of microRNAs and exosomes, such as milk exosomes are being largely ignored by the practitioners of “Western Medicine.”
Others have asked Why have microRNA biomarkers not been translated from bench to clinic? 
They have also linked the milk exosome of camels to Alternative splicing events expand molecular diversity of camel CSN1S2 increasing its ability to generate potentially bioactive peptides
When I saw this, I wrote: Unless this already has been linked from human milk exosomes to microRNA-mediated transgenerational epigenetic inheritance of morphological and behavioral phenotypes, I will use it to link camels, mice, and human populations from the Old World to the New  

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