Olfaction and microRNA signaling constrain longevity (1)

By: James V. Kohl | Published on: April 4, 2019

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.

The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.

This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA.

Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.

For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes

See for comparison: Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling (2/18/19)

…odour perception influences cell-type-specific miRNA–target interaction, thereby regulating organismal proteostasis and longevity. We anticipate that the proposed mechanism of food perception will stimulate further research on neuroendocrine brain-to-gut communication and may open the possibility for therapeutic interventions to improve proteostasis and organismal health via the sense of smell…

The molecular mechanisms that biophysically constrain energy-as-information have been detailed since the time of my 2/15/17 virtual conference presentation on Precision Medicine.
Feedback loops link the light-activated assembly of the microRNA-RNA-peptide nanocomplex to the cure for all pathology. For a historical perspective on that fact, see:
Nutrient-dependent/pheromone-controlled adaptive evolution: a model (6/14/13) Cited by the Following 2 Articles in this Archive:
Criticisms of the nutrient-dependent pheromone-controlled evolutionary model (6/4/14)
Two fatty acyl reductases involved in moth pheromone biosynthesis (7/18/16)
Also cited in:
Role of olfaction in Octopus vulgaris reproduction (2015)
See also: Feeding the brain: the importance of nutrients for brain functions and health (2017)

We are what we eat’, said the philosopher Feuerbach.

See also: Diet, Genes and Your Health: Unlock Your Genetic Potential by Using the Science of Epigenetics (2019)

Join Lucia Aronica, Lecturer, Stanford Prevention Research Center for this free webinar on epigenetics and how it can impact your overall welllness. Lucia will also be teaching the upcoming online course “Diet and Gene Expression: You Are What You Eat

When the publication history of one author is represented in the publications and presentations of others, it rare that a retraction is published. This retraction was an exception:
RETRACTED ARTICLE: MicroRNA-31-5p regulates chemosensitivity by preventing the nuclear location of PARP1 in hepatocellular carcinoma (2018)

The authors are retracting this article [1] because it overlaps significantly with a previously published article by Moody et al. [2] without proper citation.

See: MicroRNA-31 Regulates Chemosensitivity in Malignant Pleural Mesothelioma (2017)
The fact that energy-as-information biophysically constrains all virus-driven pathology via RNA interference is presented in the context of these overlaps with the representations from my history of published works.
See: Odor memories regulate olfactory receptor expression in the sensory periphery (2014)

Our study demonstrates for the first time that olfactory receptor expression is experience-dependent and modulated by scent conditioning, providing novel insight into how molecular regulation at the periphery contributes to plasticity in the olfactory system.

Publications citing this paper.

An Early Sensitive Period Induces Long-Lasting Plasticity in the Honeybee Nervous System

Odor Experiences during Preimaginal Stages Cause Behavioral and Neural Plasticity in Adult Honeybees

Expressional and functional interactions of two Apis cerana cerana olfactory receptors

Genomic footprint of evolution of eusociality in bees: floral food use and CYPome “blooms”

Access to the odor world: olfactory receptors and their role for signal transduction in insects

Computational genome-wide survey of odorant receptors from two solitary bees Dufourea novaeangliae (Hymenoptera: Halictidae) and Habropoda laboriosa (Hymenoptera: Apidae)

Molecular and functional characterization of a candidate sex pheromone receptor OR1 in Spodoptera litura.

Comparison of research methods for functional characterization of insect olfactory receptors

Identification of Complete Repertoire of Apis florea Odorant Receptors Reveals Complex Orthologous Relationships with Apis mellifera

Advances in the identification and characterization of olfactory receptors in insects.

Appetitive floral odours prevent aggression in honeybees

Differential combinatorial coding of pheromones in two olfactory subsystems of the honey bee brain.

Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees

Identification and Expression Analysis of Putative Chemosensory Receptor Genes in Microplitis mediator by Antennal Transcriptome Screening

Insect olfaction and the evolution of receptor tuning

Neurophysiological mechanisms underlying sex- and maturation-related variation in pheromone responses in honey bees (Apis mellifera)

Rapid evolution of chemosensory receptor genes in a pair of sibling species of orchid bees (Apidae: Euglossini)

A novel method to study insect olfactory receptor function using HEK293 cells.

Similar PapersFrom Fertilization to Adult Sexual Behavior, Milton Diamond, Teresa Binstock, James V. Kohl,  Hormones and Behavior (1996)

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