Olfaction and microRNA signaling constrain longevity (4)

By: James V. Kohl | Published on: April 4, 2019

See: RNAi from Petunias to Worms (2006)

Small RNAs can also be used to turn off large portions of the genome near centromeres via the RITS complex. Slightly longer RNAs (piRNAs) are playing some role in germ cell development. And many more species of RNAs keep appearing. Only 10% of the RNA in a typical cell is the conventional type of RNA (i.e. mRNA). It looks as if there was a whole RNA zoo there all along and RNAi was the entry ticket.

See also: RNA-mediated.com

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

See again, Genetic paradox explained by nonsense (2019)

…nonsense codons — signal the early cessation of the translation of messenger RNAs into proteins. Thus, an apt name for this upregulatory response is nonsense-induced transcriptional compensation (NITC).

The fact that theorists know so little about biophysically constrained RNA-mediated cell type differentiation forces them to invent new terms and acronyms each time something new is discovered about the epigenetic effects of olfaction and microRNAs on RNA interference (RNAi) and cell type differentiation. The theorists continue to hope that most people will not understand what all serious scientists know about their word-play.
Their word-play is used to obfuscate every aspect of what is known about how to link top-down causation from the epigenetic landscape to the physical landscape of supercoiled DNA.
See for instance: Epigenetic Regulations in Neuropsychiatric Disorders 4/4/19

…neuronal differentiation processes are tightly regulated by epigenetic processes including DNA methylation, histone modifications and non-coding RNAs.

What happened to the pseudoscientific nonsense about the nonsense-induced transcriptional compensation (NITC) upregulatory response, which was reported the day before?
Who didn’t realize that the nonsense and word-play would be end of neo-Darwinian theories and Big Bang cosmology?
See: Evolutionists Cannot Account for the Origin of the Sense of Smell
Theorists must now try to explain how the origin of the sense of smell feedback loops to the energy-dependent physiology of pheromone-controlled reproduction via the nonsense-induced transcriptional compensation (NITC) upregulatory response. Serious scientists can be sure that the theorists will add more nonsense, because that is all theorists have ever done.
For comparison, serious scientists have linked the sense of smell in bacteria from the physiology of pheromone-controlled reproduction to our visual perception of mass and energy in the context of transkingdom epigenetic effects of food odors and pheromones on behavior. The differences between how P. aeruginosa is linked to pathology and how P. fluorescens links sunlight to plant growth and healthy longevity via what organisms eat, links RNAi from Petunias to Worms and the patent for RNA-Guided Human Genome Engineering to the forthcoming cure for all pathology.
See also: Olfaction Warps Visual Time Perception (2018) and miRNA-223 at the crossroads of inflammation and cancer (2019)
But see for comparison: Single Nucleotide Mapping of the Locally Accessible Trait Space in Yeast Reveals Pareto Fronts that Constrain Initial Adaptation 3/30/19

…the underlying causes typically remain elusive — the genetic bases of adaptation and tradeoffs identified here provide additional potential targets for further investigation of
whether the detected tradeoffs are caused by intrinsic physiological constraints.

In other words, they are going to stick with their ridiculous gene-centric theories despite the fact that their theories have no explanatory power whatsoever.

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