Ecological Adaptations: From Angstroms to Ecosystems (2)
(click to enlarge)
From the time I published my review of biophysically constrained nutritional epigenetics, which refuted the neo-Darwinian nonsense about mutation-driven evolution, 2834 more publications have mentioned mutations and evolution. For comparison, there are ~12,370 more publications on microRNAs. The additional publications on microRNAs attest to the facts about ecological adaptations in all living genera.
For example: Non-coding RNAs and transposable elements in plant genomes: emergence, regulatory mechanisms and roles in plant development and stress responses (4/16/19)
…non-coding sequences help to regulate gene expression, and are increasingly being recognized as playing an important role in genome organization and function. In this review, we summarize the known molecular mechanisms by which gene expression is regulated by several species of non-coding RNAs (microRNAs, long non-coding RNAs, and circular RNAs) and by transposable elements. We further discuss how these non-coding RNAs and transposable elements evolve and emerge in the genome…
Only claims about the emergence of energy and the evolution of transposable elements are considered by biologically uninformed theorists.
See for example: A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly (4/18/19)
…honeybees have evolved a secreted dietary RNA-binding factor to concentrate, stabilize, and share RNA among individuals.
I detailed nutrient-dependent pheromone-controlled ecological adaptations in the honeybee model organism in: Nutrient-dependent/pheromone-controlled adaptive evolution: a model (6/14/13)
This model details how chemical ecology drives adaptive evolution via: (1) ecological niche construction, (2) social niche construction, (3) neurogenic niche construction, and (4) socio-cognitive niche construction. This model exemplifies the epigenetic effects of olfactory/pheromonal conditioning, which alters genetically predisposed, nutrient-dependent, hormone-driven mammalian behavior and choices for pheromones that control reproduction…
I placed the significance of the honeybee model organism into the context of established claims.
In the honey bee, the outputs of gene regulatory networks stemming from near identical genomes are altered by differing nutritional intakes which can be considered to be alternate trajectories along an epigenetic landscape. Differential nutrition results in different morphologies, different physiologies, different nervous systems and very different behaviors, all arising from different developmental trajectories that end in queen and worker. (Gabor Miklos & Maleszka, 2011, p. 403)
The established claims were linked to what was expected to be learned about the role of the microRNA/messenger RNA balance, which has since been established (See: microRNA Items: 1 to 20 of >85,650.
…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will certainly be discussed in published works that will follow.
For comparison, see: Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns (7/27/18)
Others who have not linked milk exosomes to all biodiversity in mammals via the physiology of pheromone-controlled reproduction include theorists who may think they have a new model.
Example: Reassessment of Exosome Composition
…we propose a new model for active secretion of extracellular DNA through an autophagy- and multivesicular-endosome-dependent but exosome-independent mechanism.
Autophagy is energy-dependent. The energy is linked to exosome-dependent mechanisms of biophysically constrained RNA-mediated cell type differentiation. So far as is known to serious scientists, there are no exosome-independent mechanisms in mammals.
That fact was tentatively established in 1964. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
The ATP-dependent exosome-dependent creation of RNA links food energy from what mammals eat to their pheromone-controlled physiology of reproduction and the transgenerational epigenetic inheritance of morphological and behavioral phenotypes.
The question arose: How did the pseudoscientific nonsense about the imaginary imagery of the black hole overshadow these facts during the week of April 10, 2019, which was when the nonsense was announced?
See for an answer: Within-host adaptation mediated by intergenic evolution in Pseudomonas aeruginosa (4/13/19)
…our results highlight the evolutionary significance of intergenic mutations in creating host-adapted strains, and that intergenic and coding regions have different qualitative contributions to this process.
Mutation-driven evolution has become ecological adaptation during the same time the creation of virucidal sunlight has been linked from the light-sucking black hole to the destruction of all light and and life.
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3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Riding the wrong direction
3 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
microRNAs and memory: Why trust a theory?
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
RNA-mediated development
2 MIN READ
0
Creating and maintaining the human virome
2 MIN READ
0
microRNAs, glycosylation, and genomes
4 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Missing a fact: microRNAs are genomic biomarkers
4 MIN READ
1
Vitamin B3 and DNA repair
4 MIN READ
0
Targeting theories to fight disease
2 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Five years of Ferguson
2 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
How to find a “holy grail” under your nose
3 MIN READ
0
MicroRNAs and the exposome (2)
< 1 MIN READ
0
MicroRNAs and the exposome
5 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Too many targets for theories
3 MIN READ
0
Creating nothing but a theory
4 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Correctly modeling biological energy
2 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
Two types of microRNA are not double agents
2 MIN READ
0
What about birds?
5 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Are viruses microRNAs?
3 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
0
Model organisms: the birds and the bees
3 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
RNA-mediated events and "The Theory of Everything"
4 MIN READ
0
Evolutionary theorists justify fear of the Ebola viruses
2 MIN READ
0
RNA-mediated genetic engineering (Part 3)
< 1 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
MiRNAs methylation and ecological adaptation sans mutations
2 MIN READ
0
Cell-type differentiation
2 MIN READ
0