The tipping point (revisited): 86,000 publications

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“Darwin had a huge data set and no mechanism—where would he publish today? This is a problem!” — Arturo Casadevall

Darwin’s light-activated “conditions of life” are microRNA-mediated. The mechanisms have been exquisitely detailed n ~86,000 indexed publications. Light-activated microRNA biogenesis in plants links the sudden appearance of flowering plants from his “abominable mystery” to the genesis of all biodiversity via what organisms eat and the physiology of reproduction.
See: microRNA  Items 1-86,000
Epigenetic effects on cell type differentiation link the light-activated assembly of the microRNA-RNA-peptide nanocomplex to biophysically constrained viral latency and all food energy-dependent pheromone-controlled biodiversity. That fact causes biologically uninformed theorists to run and hide from my Tweets @microRNApro
For example, during the past week, Elisabeth Bik,  (Microbiome digest) blocked me for the following reason.

Your tweets do not make much sense to me. I have no idea why you are accusing me of giving false information and dragging my previous employers into my personal life choices. I will now block you. Sorry.

She accused me of publishing in a “predatory journal.”
Kevin Folta blocked me with no warning.
See his comments on: Censorship of biotech researchers? Geneticist Kevin Folta excluded from gardening workshop after orchestrated anti-GMO social media attacks
Kevin claimed that viruses don’t “degrade messenger RNA.” He knows that his nonsense is well-accepted among other biologically uninformed theorists.
Ewan Birney also blocked me without warning.
I mentioned that the Hon. Commander of the British Empire, Ewan Birney, inadvertently invited retaliation from the President of the United States, who is the Commander in Chief of the US military. That claim is supported by a US Air Force Studying Impact of Exome Sequencing in Routine Care.
See the published article co-authored by Commander Birney, for example: Defining functional DNA elements in the human genome (2014)
Serious scientists do not define functional DNA elements. They link food energy to the functional structure of supercoiled DNA and they link pheromones to biophysically contrained viral latency. That is how they link the virus-driven degradation of messenger RNA from mutations to all diseases.
See: Structural diversity of supercoiled DNA (2015)

Molecular dynamics simulations independently confirm the conformational heterogeneity and provide atomistic insight into the flexibility of supercoiled DNA.

See for comparison: The atomistic insight can be view in the context of this historical perspective. It spans 6 decades of efforts made by serious scientists who have consistently linked what organisms eat from the physiology of reproduction to the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in all living geners. The historical perspective reveals why pseudoscientists have no choice but to keep discussion of facts from revealing their overwhelming ignorance.
Effects of Carnitine on Fatty-Acid Oxidation by Muscle (1959)

…it is relevant to ask by what means serum fatty acids are transported from blood vessels through the interstitial space to the active sites for fatty-acid oxidation in muscle cells.

The relevance was linked from the creation of enzymes to  metabolism of food and pheromone-controlled reproduction via:
Pheromones: a new term for a class of biologically active substances (1959)

…minute amounts cause a specific reaction in the receptor organ (the antenna of the male), which eventually leads to a state of copulative readiness. Unlike hormones, however, the substance is not secreted into the blood but outside the body; it does not serve humoral correlation within the organism but communication between individuals.

See also from 60 years ago: Pheromones (Ectohormones) in Insects (1959)

“Pheromone” should designate substances that are secreted by an animal to the outside and cause a specific reaction in a receiving individual of the same species, e.g., a release of certain behavior or a determination of physiologic development.”

…prefer the definition given above in order to exclude other chemical stimulants from the class of pheromones, especially food attractants, blossom fragrances, and insect repellents. The latter substances, although chemical releasers, do not belong to pheromones because they are not produced by individuals of the same species. Beyond that, strict species specificity is not demanded for the effect of pheromones; some overlapping is likely to occur with closely related species. Finally-with some reservations-it will discuss the determining substance in royal jelly. These substances smell very similar to the bumble bee pheromone, even to the human nose.

Hugo de Vries definition of mutations (e.g, sudden energy jumps) can be compared to what is known about the nutrient-dependent pheromone-controlled behavior of species from bees to humans.
See: Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors (2012) and Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013)
Serious scientists have continued to maintain their claims about energy that comes from the creation of sunlight and how it is linked to plant growth and all biodiversity via what organisms eat.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See: Predicting miRNA-lncRNA interactions and recognizing their regulatory roles in stress response of plants  (2019)

…networks of miRNA-mRNA, miRNA-lncRNA and miRNA-mRNA-lncRNA were constructed… analyzed and interpreted… results showed that there is a regulatory relationship between miRNA-lncRNA. New RNA targets were predicted using SVR with new gene expression mechanism and the stress related functions were annotated.

Obviously, the facts are difficult to understand. That explains this nonsense:
Fantasy Genetics Is The Most Important, And Worst, Science In Game Of Thrones (4/30/19) by Ethan Siegel

There is no evidence that a few recessive traits that we artificially value for largely-cosmetic purposes — such as eye, hair, or skin color — offer evolutionary advantages.

All traits are food energy-dependent and pheromones-controled. The EDAR V370A variant allele links the mouse-to-human model of natural selection for energy-dependent codon optimality to ~1800 hemoglobin variants. See HbVar: A Database of Human Hemoglobin Variants and Thalassemias
Ask Ethan why he wrote another article containing information that he knows nothing about.
For comparison to his ridiculous representations of fantasy genetics via a television program, see:

Reproduction in the Era of Genomics link opens pdf
==========================================
Fertility is the main key for enhancing milk and meat production and ultimately the farmer’s livelihood. Therefore, efforts from researchers all over the world have been made in improving and controlling fertility of farm animals during the last decades. Earlier studies were mainly focused on characterization and understanding of general reproductive processes both in in vivo and in vitro.

*Corresponding author: Il-Keun Kong, Republic of Korea
For more information on the historical perspective that I have briefly detailed, see its origins in: Science, state, and spirituality: Stories of four creationists in South Korea

Our historical study will thus explain why South Korea became what Ronald Numbers has called “the creationist capital of the world.”

The bull sperm micoRNAome links fescue toxicity from the virus-driven degradation of messenger RNA in soil bacteria to mutations that alter fertility in all mammals via the conserved molecular mechanisms linked to the light-activated assembly of the microRNA-RNA-peptide nanocomplex and the forthcoming cure for cancer, which is based on the measurement of fluorescence.
See: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression (2014)
See also: Accelerated Evolution Biotechnologies

The ability of different peptides to inhibit autophosphorylation of EGFR is presented by the decrease of the fluorescent signal (Y axis).

Follow the extant literature on microRNAs or suffer unnecessarily and die prematurely. That will be the legacy you leave to your descendants.
See for comparison:  microRNA Korea Items: 1 of 1871

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