The tipping point (revisited): 88K (3)
(click to enlarge)
The Woman Who Revealed the Missing Link Between Viruses and Cancer 6/17/19
In 1911, virologist Peyton Rous discovered the Rous sarcoma virus, which he concluded could transmit cancer in chickens. In 1933, Richard Shope, a physician and virologist, discovered the Shope papilloma virus, which caused keratinous carcinomas in rabbits, and three years later, biologist John Bittner demonstrated that the mouse mammary tumor virus could be transmitted from a mother mouse to her young through her milk. But it was Ludwig Gross’s work on leukemia in mice in the 1950s that would lead to the first major breakthrough in the virus-cancer link—and it was that work that Stewart took up when she moved to the NCI in 1951.
The breakthroughs led Sarah Stewart to help develop a cancer-causing HPV vaccine.
For comparison, the transgenerational epigenetic inheritance of the mouse mammary tumor virus from a mother mouse to her young through her milk is biophysically constrained.
See: Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns
Exosomes and their RNA cargos do not exclusively originate from endogenous synthesis but may also be obtained from dietary sources such as the inter-species transfer of exosomes and RNAs in bovine milk to humans.
The transfer of microRNAS in milk exosomes obviously helps to protect all mammals from viruses in this context:
Feedback loops link odor and pheromone signaling with reproduction (2005) and [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] (1994)
A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.
The mouse-to-human model of nutrient-dependent pheromone-controlled biophysically constrained viral latency was published as: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems
Biophysically constrained viral latency has since been linked from the human-specific EDAR V370A allele to populations from the Old World to the New World.
See: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk (2018)
The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection…
See for comparison: Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS (6/4/19)
Reported on 6/17/19 as Schizophrenia: Adolescence is the game-changer
The virus-driven degradation of messenger RNA links the COMT Val158Met allele to prevention of schizophrenia, school shootings, and suicides.
See also: comt val158met Items: 1 to 898
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0
Amino acid substitutions, stress, and human behavior
3 MIN READ
0
Finding peace and π in the light of H bond energy (2)
8 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Perry Marshall: too much information for atheist PZ Myers
3 MIN READ
0
Assumptions prove ignorance (2)
5 MIN READ
0
Epigenetic (re)programming of behavior
4 MIN READ
0
Assumptions prove ignorance
5 MIN READ
0
Neo-Darwinian sink testing
2 MIN READ
0
NORAD: air defense and defense against genomic entropy
7 MIN READ
0
Did Dobzhansky see the UV light of creation?
10 MIN READ
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5 MIN READ
0
Does metabolism link beneficial mutations to cancer?
10 MIN READ
0
RNA-mediated theory killers (4)
9 MIN READ
0
RNA-mediated theory killers (5)
2 MIN READ
0
RNA-mediated regulatory mechanisms link microbes to humans (3)
5 MIN READ
0
Nutrient-dependent trophic analogs (2)
6 MIN READ
0
Essential pseudoscientific concepts of atheism
3 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
Natural cooperation and Evolution 2.0
6 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (3)
8 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (2)
4 MIN READ
0
Teaching the biologically uninformed
3 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs
9 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Nutrient-dependent trophic analogs
3 MIN READ
0
Stress-perturbed mitochondrial dysfunction (2)
5 MIN READ
0
Stress-perturbed mitochondrial dysfunction
4 MIN READ
0
Let there be anti-entropic light (3)
6 MIN READ
0
Theorists can’t understand biology
6 MIN READ
0
Sensationalizing no new mechanism
2 MIN READ
0
Models are not theories (3)
3 MIN READ
0
Too complex for the Complex Biological Systems Alliance
4 MIN READ
0
Virus, transposon and plasmid evolution
< 1 MIN READ
0
Models are not theories (2)
2 MIN READ
0
MicroRNA-encoded behavior
7 MIN READ
0
Can veterans and other prisoners escape pseudoscience?
2 MIN READ
0
RNA central and RNA-mediated.com
6 MIN READ
0
Ecological speciation. Get it, theorists?
< 1 MIN READ
0
The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
Neo-Darwinian logic is nonsense
3 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Epigenetic inheritance of stress-perturbed protein folding
2 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Checkpoint checkmate: viruses lose if conditions of life win
< 1 MIN READ
0
Cancer: forward and reverse
2 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Virucidal effects on ecological speciation
5 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Metaphysical science vs theory
4 MIN READ
0
Mechanisms of stress: from genes to cancer
9 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
A 5-10K comparison of design principles to evolution
3 MIN READ
0
Alternative pre-mRNA splicing and ecological adaptation
7 MIN READ
0
Pathology: Eating and breathing viruses
2 MIN READ
0
Exosomes and the RNA-mediated future of medicine (3)
2 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
Information and communication
2 MIN READ
0
Olfaction & the octopus and human genomes (2)
4 MIN READ
0
Thermodynamic constraints did not evolve
3 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
Viruses, amino acids, and somatic cell types (3)
9 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
Hematopoiesis and practopoiesis
4 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
Riding the wrong direction
3 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
The RNA-mediated sum of our parts
2 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
microRNAs and memory: Why trust a theory?
2 MIN READ
0
Iron, ferritin, thyroxine
2 MIN READ
0
“First” evidence
5 MIN READ
0
RNA-mediated development
2 MIN READ
0
microRNAs, glycosylation, and genomes
4 MIN READ
0
Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
Batch effect vs epigenetic effects
3 MIN READ
0
Missing a fact: microRNAs are genomic biomarkers
4 MIN READ
1
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Targeting theories to fight disease
2 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Five years of Ferguson
2 MIN READ
0
Virus-driven cancer treatment and prevention
2 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
From gut bacteria to breast milk and back
5 MIN READ
0
How to find a “holy grail” under your nose
3 MIN READ
0
MicroRNAs and the exposome (2)
< 1 MIN READ
0
MicroRNAs and the exposome
5 MIN READ
0
Epigenetics vs the fossil record
4 MIN READ
0
Thermodynamics and protein folding landscapes
2 MIN READ
0
Re-inventing a completely new thing
4 MIN READ
0
Feedback loops link insects to human brains
2 MIN READ
0
The Darwin Code by Greg Bear
13 MIN READ
0
Genetic chimerism and ecological adaptation
4 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
A genetic variant refutes neo-Darwinism
6 MIN READ
0
Silencing genes and serious scientists
3 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Life: conserved ion and amino acid transporters
3 MIN READ
0
Too many targets for theories
3 MIN READ
0
Creating nothing but a theory
4 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Correctly modeling biological energy
2 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
Two types of microRNA are not double agents
2 MIN READ
0
What about birds?
5 MIN READ
0
Virus-driven cell type differentiation
2 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Are viruses microRNAs?
3 MIN READ
0
Constrained evolution is ecological adaptation
5 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Glycine and GnRH: Am I being pedantic?
4 MIN READ
0
RNA-mediated events and "The Theory of Everything"
4 MIN READ
0
More than a bag of chemicals?
2 MIN READ
0
Nothing new under the sun, except pseudoscientific nonsense
6 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
Evolutionary theorists justify fear of the Ebola viruses
2 MIN READ
0
RNA-mediated events: chromosomal rearrangements and genomic rearrangements
2 MIN READ
2
RNA-mediated genetic engineering (Part 3)
< 1 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
Evolving DNA before RNA
4 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
Watching and waiting for more retractions
2 MIN READ
0
Genotype, observed phenotype, and distinctly disordered behaviors
3 MIN READ
0
Nutrition, pheromones and cancer (2)
2 MIN READ
0
Ecologically linked adapted ants and brains
2 MIN READ
0
Cell-type differentiation
2 MIN READ
0
Targeting a cancer gene
2 MIN READ
0
Pheromone-controlled thermodynamics and cancer
2 MIN READ
0
Pheromones and cancer
4 MIN READ
0
Evolution at work sans random mutations (Part 2)
< 1 MIN READ
0
Honeybees, food odors, and perfume
< 1 MIN READ
0
