MicroRNA-mediated enhancer-promoter chemistry
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Summary: The claim that loop extrusion and homotypic attraction are two antagonistic fundamental forces that are linked to what enhancer-promoter contacts and chromatin domains physically represent exemplifies human idiocy.
Regulatory Landscaping: How Enhancer-Promoter Communication Is Sculpted in 3D (6/20/19)
We focus on emerging views of what enhancer-promoter contacts and chromatin domains physically represent and how two antagonistic fundamental forces—loop extrusion and homotypic attraction—likely form them.
They refuse to focus on what is known to all serious scientists about the energy-dependent link from endogenous substrates to biophysically constrained viral latency and healthy longevity.
Substrate:
In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product. In synthetic and organic chemistry, the substrate is the chemical of interest that is being modified.
Endogenous substances… originate from within a system such as an organism, tissue, or cell. The term is chiefly used in biology but also in other fields. Endogenous substances and processes contrast with exogenous ones, such as drugs, which originate from outside of the organism.
Vaccines are like drugs and genetically modified organisms (GMOs). They are exogenous sources of virus-driven pathology because they come from outside of the organism. Endogenous retroviruses are also sources of pathology when nutrient-stress and/or social stress reactivate them.
Chemists know that energy is required to modify the substrates of interest to biologists. See Chemists Know. Theorists know nothing of importance for comparison.
Serious scientists detailed the importance of feedback loops that biophysically constrain viral latency via light-activated endogenous substrates. The substrates exemplify the eternal significance of microRNAs, which are the endogenous substrates. Simply put, endogenous substrates are the Alpha (Α or α) and omega (Ω or ω) of biologically-based cause and effect.
I didn’t know why in 1992, but Bruce McEwen told me that my model could not be validated unless I started with gene activation in gonadotropin releasing hormone neurosecretory neurons. Since then, I learned that microRNAs are the endogenous substrates that link food odors and pheromones to the representations of biologically-based cause and effect in the model that he patiently discussed with me.
Others who have followed the extant literature will find evidence of confusion in claims of others about models. See: Ecological and evolutionary consequences of viral plasticity (2019)
For bacteriophages, this link between host and viral performance has been characterized empirically and with intracellular theories. Such theories are too detailed to be included in models that study host-phage interactions in the long term, which hinders our understanding of systems that range from pathogens infecting gut bacteria to marine phage shaping the oceans.
The theories are not well-detailed because they are based on other theories. Facts led to this model of host-phage interactions across kingdoms for comparison to their ridiculous claim that
…plasticity on the offspring number drives the phage ecological and evolutionary dynamics by reinforcing feedbacks between host, virus, and environment.
No offspring exist outside the context of Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (4/11/18)
This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experiencedependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity. Species-specific pheromones link quorum-sensing in microbes from chemical ecology to the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection for codon optimality links nutritional epigenetics to the behaviors that enable ecological adaptations. All biodiversity is an ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. Simply put, olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.
See for validation: Exosome-delivered microRNAs modulate the inflammatory response to endotoxin (6/18/15)
…endogenous microRNAs undergo a functional transfer between immune cells and constitute a mechanism of regulating the inflammatory response.
See also: Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns (7/27/18)
MicroRNAs in milk exosomes are the substrates that exemplify how the eternal significance of microRNAs, which are the endogenous substrates, must be linked to all biodiversity across kingdoms to mammals via food odors and pheromones.
See: Unexpected Potential of Iso-oligosaccharides in the Generation of Important Food Odorants
The generation of selected Maillard-derived odorants from iso-oligosaccharides (IOSs), namely, from isomaltose, isomaltotriose, isomaltulose, and melibiose, was studied and… newly obtained data brought for the first time evidence about the extraordinary potential of IOSs in the formation of several potent food odorants.
The binary mixtures of sugar and the amino acids glycine, proline, and cysteine could have led them to proclaim the the fixation of achiral glycine in positon 6 of the GnRH decapeptide was the key to biophysically contrained viral latency and all diversity among all vertebrates with jaws.
But they missed the obvious connection to amino acid substitution-dependent biophysically constrained viral latency in invertebrates.
See: Pathway of 5-hydroxymethyl-2-furaldehyde formation in honey
…different content of proline, the most abundant amino acid in honey (a substance in Maillard reaction), had no effect on 5-HMF formation. Free acids in honey can catalyze fructose and glucose to form 5-HMF. These results suggest that dehydration of glucose or fructose, instead of the Maillard reaction, is the main pathway of 5-HMF formation in honey. This study gives new insights for the mechanisms of 5-HMF formation and provides method for reducing 5-HMF formation during honey processing.
Dehydration of glucose or fructose link the creation of the amino acid proline to the potential of hydrogen (pH). The energy of hydrogen comes from the sun. The effect of sunlight can be linked to all downstream effects on cell type differentiation by anyone who starts with the creation of sunlight and links it to pH and the creation of different amino acids, which change food odors, flavors, and colors across kingdoms.
See: The effect of pH and amino acids on the formation of methylglyoxal in a glucose-amino acid model system
Amino reactivity and pH were two important factors affecting the formation of MGO in the Maillard reaction.
The energy-dependent pH-dependent creation of amino acids and fixation of amino acid substitutions in the organized genomes of species from microbes to humans biophysically contrain viral latency. That fact makes the claims about enhancers and promoters appear to be among the claims made by biologically uninformed science idiots who know nothing about healthy longevity.
See also: Dietary Maillard reaction products and their fermented products reduce cardiovascular risk in an animal model
This study examined the effects of Maillard reaction products (MRP) and MRP fermented by lactic acid bacteria on antioxidants and their enhancement of cardiovascular health in ICR mouse and rat models. In previous in vitro studies, the selected lactic acid bacteria were shown to significantly affect the activity of MRP. The expression of genes (e.g., superoxide dismutase, catalase, and glutathione peroxidase) related to antioxidant activity was upregulated by Maillard-reacted sodium caseinate (cMRP), and cMRP fermented by Lactobacillus fermentum H9 (F-cMRP) synergistically increased the expression of catalase and superoxide dismutase when compared with the high-cholesterol-diet group. Bleeding time, the assay for determination of antithrombotic activity, was significantly prolonged by Maillard-reacted whey protein concentration (wMRP) and wMRP fermented by Lactobacillus gasseri H10 (F-wMRP), similar to the bleeding time of the aspirin group (positive control). In addition, the acute pulmonary thromboembolism?induced mice overcame severe body paralysis or death in both the wMRP and the F-wMRP groups. In the serum-level experiment, cMRP and F-cMRP significantly reduced the serum total and low-density lipoprotein cholesterol levels and triglycerides but had only a slight effect on high-density lipoprotein cholesterol. The levels of aspartate transaminase and alanine transaminase also declined in the cMRP and F-cMRP intake groups compared with the high-cholesterol-diet group. In particular, F-cMRP showed the highest reducing effects on triglycerides, aspartate transaminase, and alanine transaminase. Moreover, the expression of cholesterol-related genes in the F-cMRP group demonstrated greater effects than for the cMRP group in the level of cholesterol 7 α-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), and low-density lipoprotein receptors compared with the high-cholesterol-diet group. The protective role of cMRP and F-cMRP in the high-cholesterol group may have been the result of an antioxidative defense mechanism that regulated cholesterol synthesis and metabolism. Therefore, F-cMRP and cMRP have the potential to play preventive and therapeutic roles in the management of cardiovascular disease.
See for comparison: microRNA “cardiovascular disease” Items: 1- 1156 and enhancer promoter “cardiovascular disease”Items: 1 to 57 and enhancer promoter “cardiovascular disease” microRNA
Fibrinogen gene regulation (2012)
…we discuss regulation of the fibrinogen genes from proximal promoters and enhancers, the influence of acute-phase stimulation, post-transcriptional regulation by miRNAs and functional regulatory variants identified in genetic studies.
Non-coding RNAs as regulators of gene expression and epigenetics (2011)
Genome-wide studies have revealed that mammalian genomes are pervasively transcribed. This has led to the identification and isolation of novel classes of non-coding RNAs (ncRNAs) that influence gene expression by a variety of mechanisms. Here we review the characteristics and functions of regulatory ncRNAs in chromatin remodelling and at multiple levels of transcriptional and post-transcriptional regulation. We also describe the potential roles of ncRNAs in vascular biology and in mediating epigenetic modifications that might play roles in cardiovascular disease susceptibility. The emerging recognition of the diverse functions of ncRNAs in regulation of gene expression suggests that they may represent new targets for therapeutic intervention.
What has anyone who ever mentioned enhancers and promoters done to link microRNA-mediated enhancer-promoter chemistry to healthy longevity via what is known to all serious scientists about cardiovascular disease susceptibility or susceptibility to any other form of virus-driven pathology.
For comparison, see: microRNA Items: 1 to 88068
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The end of theistic evolution (1)
2 MIN READ
0
microRNA-mediated prevention of diseases (1)
2 MIN READ
0
Ignoring effects of microRNAs on Twitter (1)
3 MIN READ
0
The tipping point (revisited): 95K (2)
2 MIN READ
0
The tipping point (revisited): 95K (1)
< 1 MIN READ
0
MicroRNAs biophysically constrain Virus-driven pathology (6)
3 MIN READ
0
microRNAs Constrain Virus-driven Pathology (1)
2 MIN READ
0
Viral latency vs secular humanism (1)
2 MIN READ
0
Patented Creation vs Evolution of Disease (9)
4 MIN READ
0
Patented Creation vs Evolution of Disease (8)
3 MIN READ
0
Chemogenetic kinetics (7): DHA vs consensus (2)
3 MIN READ
0
MicroRNA-mediated, since 1964 (1)
2 MIN READ
0
Trans-kingdom RNA interactions (3)
3 MIN READ
0
Sex differences: Liberals vs Conservatives (1)
4 MIN READ
0
Nutrient-dependent Pheromone-controlled cures (4)
2 MIN READ
0
Brokered regulatory leverage: Breaking Bad (1)
5 MIN READ
0
Sunlight, hydrophobicity and biodiversity (3)
5 MIN READ
0
Bastardized health care (5)
4 MIN READ
0
Weaponized health information (8)
6 MIN READ
0
Weaponized Health Communication (2)
4 MIN READ
0
Weaponized Health Communication (1)
3 MIN READ
0
The tipping point (revisited): 89K (4)
3 MIN READ
0
Genetic endemism: apologetics vs epigenetics (2)
3 MIN READ
0
Genetic endemism: apologetics vs epigenetics (1)
2 MIN READ
0
Light-altered chirality and microRNA biogenesis (1)
4 MIN READ
0
pH, amino acids, and health: Effects of sunlight and well wishes
2 MIN READ
0
Trump-hating advocates of vaccines + GMOs (3)
5 MIN READ
0
Anthony S. Fauci refutes theistic evolution
3 MIN READ
0
Trump-hating advocates of vaccines + GMOs (1)
4 MIN READ
0
Abiogenesis vs microRNA biogenesis (3)
3 MIN READ
0
The tipping point (revisited): 87K (3)
4 MIN READ
0
The tipping point (revisited): Genetics & Genomics 2019
5 MIN READ
0
The tipping point (revisited): SETD2
3 MIN READ
0
Kohl and Francoeur at 25 (8)
2 MIN READ
0
Light and life-sucking black holes (2)
2 MIN READ
0
Kohl and Francoeur at 25 (7)
3 MIN READ
0
The tipping point (revisited): 85,000 publications
4 MIN READ
0
Kohl and Francoeur at 25 (3)
3 MIN READ
0
Epic failure of the FDA: Gottlieb resigns (1)
3 MIN READ
0
Biophysical constraints on RNA synthesis (1)
9 MIN READ
0
Preprints obfuscate facts (2)
4 MIN READ
0
RNA processing and disease (3)
3 MIN READ
0
Ecological adaptation vs neo-Darwinian nonsense (1)
2 MIN READ
0
Darwin Day 2019 (2) #darwinday2019
4 MIN READ
0
Do not call me Ishmael (4)
< 1 MIN READ
0
Do not call me Ishmael (2)
2 MIN READ
0
Do not call me Ishmael (1)
3 MIN READ
0
Phytoremediation, Microbiome and CRISPR (4)
4 MIN READ
0
Phytoremediation, Microbiome and CRISPR (3)
5 MIN READ
0
Autophagy automagically prevents cancer (2)
2 MIN READ
0
Phytoremediation, Microbiome and CRISPR (1)
3 MIN READ
0
Light-activated continuous environmental tracking (2)
3 MIN READ
0
Light-activated constrained biodiversity (2)
4 MIN READ
0
Light-activated constrained biodiversity
7 MIN READ
0
Light-activated carbon fixation (2)
3 MIN READ
0
The tipping point (revisited): 82,000 publications (5)
3 MIN READ
0
The tipping point (revisited): 82,000 publications (1)
3 MIN READ
0
Viral latency vs deadly paleoanthropology (1)
4 MIN READ
0
Light and life at base pair resolution (10)
4 MIN READ
0
Plant microRNAs regulate across-kingdom gene expression (2)
5 MIN READ
0
Plant microRNAs regulate across-kingdom gene expression (1)
2 MIN READ
0
Science journalism: a threat to humanity (1)
3 MIN READ
0
The tipping point (revisited): 81,000 publications (1)
5 MIN READ
0
Hide and seek with science facts (8)
2 MIN READ
0
Hide and seek with science facts (7)
3 MIN READ
0
Hide and seek with science facts (6)
2 MIN READ
0
The perfect symmetry of nature
2 MIN READ
0
Happy Veteran’s Day 2018 (2)
4 MIN READ
0
SfN’s 2018 trap set for Democrats
2 MIN READ
0
79,000 reasons to believe in biophysical constraints
8 MIN READ
0
10,000 reasons to believe in biophysical constraints (2)
6 MIN READ
0
Evolved suffering and death caused by statistical significance
< 1 MIN READ
0
Creation of an enzyme that kills theories (3)
8 MIN READ
0
War Games: False Flag Terrorism (4)
3 MIN READ
0
Creating an enzyme that kills theories (1)
< 1 MIN READ
0
Biologos bastardized it all, again
3 MIN READ
0
Are Kavanaugh’s accusers terrorists?
4 MIN READ
0
Diagnosis: 120 years of human idiocy
< 1 MIN READ
0
Information Wars started by medical practitioners (1)
< 1 MIN READ
0
Natural models inspire future therapeutics (2)
2 MIN READ
0
Predicting naturally occurring viral latency
3 MIN READ
0
The concept of a species (3)
4 MIN READ
0
The concept of a species (1)
2 MIN READ
0
The tipping point (revisited): 74,000 publications
4 MIN READ
0
MicroRNA-mediated alternative splicing (revisited)
4 MIN READ
0
Animal welfare vs human ethology
4 MIN READ
0
Biologically uninformed science idiot: Self-defense (1)
3 MIN READ
0
The eternal significance of microRNAs and the Vietnam Memorial (2)
4 MIN READ
0
The eternal significance of microRNAs and the Vietnam Memorial (1)
3 MIN READ
0
Cracks in The Granite Wall (2)
4 MIN READ
0
From quantum physics to quantum souls (2)
2 MIN READ
0
Epigenetic inheritance of spatiotemporal regulation (5)
8 MIN READ
0
The origin of information (5,4,3,2,1)
3 MIN READ
0
The eternal significance of microRNAs (5)
2 MIN READ
0
A single base change refutes theistic evolution (2)
2 MIN READ
0
A single base change refutes theistic evolution
5 MIN READ
0
EDAR V370A and sympatric speciation
2 MIN READ
0
Virus-driven cystinosis
2 MIN READ
0
Environmental selection is natural selection (4)
2 MIN READ
0
Environmental selection is natural selection
3 MIN READ
0
MicroRNA-mediated denuclearization (6)
2 MIN READ
0
MicroRNA-mediated denuclearization (4)
2 MIN READ
0
Abiogenesis vs microRNA biogenesis (2)
7 MIN READ
0
2018 March for Science vs microRNAs (2)
4 MIN READ
0
2018 March for Science vs microRNAs
7 MIN READ
0
The eternal significance of microRNAs (1) – revisited
2 MIN READ
0
The eternal significance of microRNAs (1)
< 1 MIN READ
0
Sympatric Speciation vs pseudosceintific nonsense (4)
2 MIN READ
0
Complexity: Routes and Patterns (4)
< 1 MIN READ
0
Let there be anti-entropic virucidal light
3 MIN READ
0
RNA-mediated nutritional psychiatry (2)
2 MIN READ
0
RNA-mediated nutritional psychiatry
4 MIN READ
0
Part 2: Light-controlled cell biology (revisited)
2 MIN READ
0
Polymaths and paradigm shifts: From Asimov to Bear (5)
5 MIN READ
0
Polymaths and paradigm shifts: from Asimov to Bear (1)
5 MIN READ
0
Carl Zimmer refutes theistic evolution (2)
2 MIN READ
0
Ecological adaptation: A new definition of heredity (3)
4 MIN READ
0
Creating biophysically constrained viral latency (2)
2 MIN READ
0
Anti-entropic sunlight: Schrödinger’s Creationist Secret? (5)
2 MIN READ
0
Light-activated carbon fixation did not evolve (4)
7 MIN READ
0
How to biophysically constrain the flu virus (1)
4 MIN READ
0
Cryo-EM: Linking spatial and conformational constraints
9 MIN READ
0
Subatomic: From thermophiles to humans (2)
6 MIN READ
0
A reversible TCA cycle in a thermophile (3)
4 MIN READ
0
A reversible TCA cycle in a thermophile (2)
3 MIN READ
0
A mental health problem at the highest level (3)
7 MIN READ
0
Diet-driven RNA interference and mental health (3)
4 MIN READ
0
Anti-entropic sunlight: Schrödinger’s Creationist Secret? (3)
6 MIN READ
1
Anti-entropic sunlight: Schrödinger’s Creationist Secret? (2)
4 MIN READ
0
BiondVax Universal Flu Vaccine Patent
4 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (5)
6 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (3)
4 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (2)
6 MIN READ
0
The tipping point (revisted): 69,000 publications
4 MIN READ
0
A mental health problem at the highest level (2)
3 MIN READ
0
Diet-driven RNA interference and cancer prevention (3)
6 MIN READ
0
Autophagy is the antiphage defense strategy (2)
4 MIN READ
0
Enzyme-constrained interethnic diversity (8)
< 1 MIN READ
0
Enzyme-constrained interethnic diversity (7)
6 MIN READ
0
Diet-driven RNA interference and cancer prevention (2)
< 1 MIN READ
0
Enzyme-constrained interethnic biodiversity (1)
5 MIN READ
0
The “walking fish” walks straight from quantum physics to quantum souls (4)
11 MIN READ
0
The “walking fish” walks straight from quantum physics to quantum souls (2)
3 MIN READ
0
A Mathematical Model Links Quantum Physics to Quantum Souls (1)
6 MIN READ
0
From base editing to RNA editing (6)
8 MIN READ
0
Kinetically Stable Thermodynamically Activated Cell Metabolism (2)
4 MIN READ
0
Darwinian adaptation: a clear evolutionary trail?
4 MIN READ
0
Agilent technology and energy-dependent autophagy
8 MIN READ
0
Tai Chi vs PTSD and cancer
< 1 MIN READ
0
Trump challenges the CDC to remember 9/11
14 MIN READ
0
Narcissistic egomaniacal and deadly denial of autophagy
6 MIN READ
0
Elsevier fails to support the concept of autophagy
4 MIN READ
0
From Autophagy.pro (transitions)
4 MIN READ
0
Nature vs Science and Autophagy.pro
7 MIN READ
0
The overwhelming ignorance of sex researchers (2)
4 MIN READ
0
Energy-dependent base editing and correction of mutations (2)
9 MIN READ
0
Trashing the 2nd Law
7 MIN READ
0
The overwhelming ignorance of sex researchers
5 MIN READ
0
Two retractions of human idiocy
2 MIN READ
0
Exposing the 2nd Law to more ridicule (1)
6 MIN READ
0
Reporting new scientific truths is not allowed in the USA
3 MIN READ
0
Denying Creation via RNA-directed DNA methylation
4 MIN READ
0
Light-activated error-free DNA repair (4)
3 MIN READ
0
MicroRNAs and the Cassandra syndrome (revisited)
4 MIN READ
0
A null mutation and healthy longevity?
4 MIN READ
0
Light-activated error free DNA repair
5 MIN READ
0
Achromobacter and killer theories
2 MIN READ
0
Eutrophication and phosphorylated biodiversity
6 MIN READ
0
Pheromones biophysically constrain RNA-mediated biodiversity (1)
5 MIN READ
0
The next reformation: 500 years too late? (1)
< 1 MIN READ
0
The next reformation: 500 years too late? (2)
2 MIN READ
0
From base editing to RNA editing (2)
7 MIN READ
0
Cryo-EM: More than a suggestion
< 1 MIN READ
0
Exome Sequencing Impact in Routine Care
4 MIN READ
0
Virulence: Out of stock
2 MIN READ
0
Energy-dependent structure and function: Until death (5)
4 MIN READ
0
Energy-dependent structure and function: Until death (3)
3 MIN READ
0
Energy-dependent structure and function: Until death (2)
5 MIN READ
0
Energy-dependent structure and function: Until death (1)
4 MIN READ
0
Until death: Virus-driven failure of multisensory integration (1)
4 MIN READ
0
Entertaining yourself to death
6 MIN READ
0
Predicting who wins the 2017 Nobel Prizes (5)
2 MIN READ
0
Predicting who wins the 2017 Nobel Prizes (2)
4 MIN READ
0
Life and death via chemical effects on photosynthesis
8 MIN READ
0
Sci-Hub vs limits on the dissemination of information
6 MIN READ
0
Evolutionary theories of epigenetic drift
2 MIN READ
0
Inventing “Transcriptome Trajectory Turning Points”
2 MIN READ
0
Methylation and the innate immune system (2)
4 MIN READ
0
Science vs Secularism: Molecular Mechanisms or Math?
6 MIN READ
0
Methylation and the Innate Immune System
< 1 MIN READ
0
A fear of pheromones (revisited)
6 MIN READ
0
Host-derived creation of all pathology (2 of 2)
9 MIN READ
0
God vs host-derived creation of virus-driven pathology
6 MIN READ
0
Pseudoscientists hate what science explains!
3 MIN READ
0
Energy and neural plasticity
< 1 MIN READ
0
Your indifference is killing you and others
5 MIN READ
0
Your indifference is killing you and others (4)
4 MIN READ
0
Robert Sapolsky’s legacy of atheistic pseudoscientific nonsense
4 MIN READ
0
The Origin of Information (4)
4 MIN READ
0
New Testament Book Cover Refutes Theistic Evolution
7 MIN READ
0
Energy-dependent physical and biophysical constraints (10)
8 MIN READ
0
Energy-dependent physical and biophysical constraints (7)
2 MIN READ
0
Energy-dependent physical and biophysical constraints (6)
8 MIN READ
0
Energy-dependent physical and biophysical constraints (5)
7 MIN READ
0
Energy-dependent physical and biophysical constraints (3)
2 MIN READ
0
MicroRNAs GnRH and the failure of sex research
7 MIN READ
0
God’s shrinking role in salvation (2)
5 MIN READ
0
Food energy-dependent cell type differentiation (2)
10 MIN READ
0
Hard Science vs the neo-Darwinian “magic box”
9 MIN READ
0
MicroRNAs light up life
7 MIN READ
0
From E. coli to monkeys and mankind: Theories vs models (5)
5 MIN READ
0
Food energy-dependent epigenetic adaptation (3)
3 MIN READ
0
Food energy-dependent epigenetic adaptation (2)
< 1 MIN READ
0
Energy-dependent epigenetic translation to mRNA stability (5)
4 MIN READ
0
What energy source do proteins prefer?
6 MIN READ
0
Draining the academic swamp of parasites
3 MIN READ
0
Dispensing with all pseudoscientific nonsense about evolution (1)
5 MIN READ
0
The Virus-Driven Suicide March for Science
5 MIN READ
0
Virus-driven downsizing of the human brain (4)
2 MIN READ
0
Viruses in pathogenic variants disrupt alternative splicings (2)
3 MIN READ
0
Respiration-dependent endogenous RNA interference
4 MIN READ
0
Epigenetically-effected nucleosome repositioning sheds Dobzhansky’s light on evolution
3 MIN READ
0
Functionally interdependent editing and methylation
4 MIN READ
0
Cytosis: Biology Content
7 MIN READ
0
Who will kill the billion dollar baby? Bill Gates or Donald Trump
3 MIN READ
0
Food for thought: Penrose v Ellis (3)
4 MIN READ
0
Magnussen’s “Faith fools” keep the faith
3 MIN READ
0
Proof: Sunlight is energy as information
< 1 MIN READ
0
Energy-dependent pheromone-controlled entropy (1)
4 MIN READ
0
The essence of precision medicine: drug targets or healthy longevity?
4 MIN READ
0
The essence of precision medicine
4 MIN READ
0
Allen Institute confirms food energy is information
6 MIN READ
0
RNA-mediated adult learning, memory, and neurogenesis
3 MIN READ
0
Energy-dependent allelic imbalances, viruses, and pathology
3 MIN READ
0
Theistic evolutionists fight back and lose
4 MIN READ
0
Bill Gates refutes theistic evolution (sequel)
8 MIN READ
0
Bill Gates refutes theistic evolution
4 MIN READ
0
May the anti-entropic force of sunlight be with you
4 MIN READ
0
Francis S. Collins refutes theistic evolution
6 MIN READ
0
Happy Darwin Day (2017)
4 MIN READ
0
George Church refutes theistic evolution (3)
5 MIN READ
0
George Church refutes theistic evolution
5 MIN READ
0
Mitochondria do not adapt
2 MIN READ
0
Energy as information and constrained endogenous RNA interference (3)
4 MIN READ
0
Energy as information and constrained endogenous RNA interference (2)
2 MIN READ
0
Dobzhansky 1973 and precision medicine (5)
3 MIN READ
0
Dobzhansky 1973 and precision medicine (4)
5 MIN READ
0
Science journalists or paid propagandists? (2)
3 MIN READ
0
Science journalists or paid propagandists?
5 MIN READ
0
Energy-dependent hydrogen bonds in supercoiled DNA
7 MIN READ
0
Energy-dependent chirality (2)
3 MIN READ
0
Energy-dependent chirality
6 MIN READ
0
Energy-dependent alternative splicings 1996 – 2016 (2)
5 MIN READ
0
Vietnam Veterans and others with glioblastoma
3 MIN READ
0
Energy-dependent sensory maps (1996-2016)
5 MIN READ
0
Re-inventing mutation-driven evolution (2)
4 MIN READ
0
Energy-dependent self-organization and self repair
8 MIN READ
0
Explorers who do not know what is known (2)
6 MIN READ
0
Autophagy is the antiphage defense strategy
3 MIN READ
0
Tasting light links energy from creation to adaptation
9 MIN READ
0
Combating evolution: Battlefield medicine vs politicized science
6 MIN READ
0
The futility of The Battlefield FB group
10 MIN READ
0
Metabolic Phenotyping Research
2 MIN READ
0
Energy-dependent coulombic, autophagic, polycombic healthy longevity
4 MIN READ
0
Energy-dependent purifying selection / autophagy (3)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (6)
3 MIN READ
0
Energy-dependent purifying selection / autophagy
2 MIN READ
0
Virus-driven mutation or amino acid substitution
5 MIN READ
0
Epigenetically effected energy-dependent fluorescence (2)
6 MIN READ
0
Epigenetically effected energy-dependent fluorescence
5 MIN READ
0
From Precis to Proof in 6000 years (2)
5 MIN READ
0
From Precis to Proof in 6000 years
9 MIN READ
0
Polycombic ecological adaptation as a science, not a theory (2)
12 MIN READ
0
Polycombic ecological adaptation as a science, not a theory
3 MIN READ
0
80 years of causal analysis (1936 – 2016)
11 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
Life is energy-dependent task management (2)
3 MIN READ
0
Life is energy-dependent task management
3 MIN READ
0
Hypothesis free pseudoscience vs facts (5)
6 MIN READ
0
Hypothesis free pseudoscience vs facts (1)
5 MIN READ
0
Hydrogen-atom energy in DNA base pairs
6 MIN READ
0
DNA repair via junk DNA (2)
5 MIN READ
0
The Aquatic Ape / Waterside Ape divergence
6 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
How did the innate immune system evolve?
4 MIN READ
0
The Aquatic Ape: New evidence?
4 MIN READ
0
Protecting 4 billion people from virus-driven entropy
< 1 MIN READ
0
Lawless evolution: No physics
4 MIN READ
0
Antithetical conclusions (7)
3 MIN READ
0
Antithetical conclusions (4)
3 MIN READ
0
Non-random pheromone-controlled cell type differentiation
3 MIN READ
0
RNAi: From magic bullet to billion dollar baby
4 MIN READ
0
GC-rich neo-Darwinian train wreck
5 MIN READ
0
Biophysically constrained cell type differentiation
3 MIN READ
0
From angstroms to ecosystems
7 MIN READ
0
Food supplement or licensed immunostimulant?
6 MIN READ
0
Virus-driven downsizing of the human brain (3)
4 MIN READ
0
The end of neo-Darwinism
5 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity
4 MIN READ
0
The Origin of Information (2)
6 MIN READ
0
Did “Nature” kill Steve Jobs? (3)
10 MIN READ
0
Did “Nature” kill Steve Jobs? (2)
6 MIN READ
0
Did “Nature” kill Steve Jobs?
3 MIN READ
0
Virus-driven downsizing of the human brain (2)
< 1 MIN READ
0
Placing boundaries where none exist
< 1 MIN READ
0
Innate immunity and multiplexing
7 MIN READ
0
RNA methylation (2)
7 MIN READ
0
Major transition ends use of silly theories
5 MIN READ
0
Masters of deception about nature (2)
7 MIN READ
0
Cracking the Olfactory Code?
5 MIN READ
0
Energy-dependent RNA methylation (9)
2 MIN READ
0
Energy-dependent RNA methylation (7)
7 MIN READ
0
Energy-dependent RNA methylation (6)
9 MIN READ
0
Energy-dependent RNA methylation (5)
3 MIN READ
0
The tipping point? 50, 000 publications (2)
2 MIN READ
0
Countdown to Genetics and Genomics
< 1 MIN READ
0
Energy-dependent creation and entropy
4 MIN READ
0
RNA splicing, genetic variation, and disease
2 MIN READ
0
Effects on invertebrate GnRH and affects on primate behavior
6 MIN READ
0
The Light and Darkness of “Evolution 2.0”
11 MIN READ
0
Blood test links atoms to ecosystems
2 MIN READ
0
Juvenile hormone links atoms to ecosystems
3 MIN READ
0
Genes, orchid odors, and pheromones from blonds
5 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Assumptions prove ignorance
5 MIN READ
0
RNA-mediated theory killers (4)
9 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
RNA-mediated theory killers
6 MIN READ
0
Sulfated steroids and RNA-mediated identity codes
< 1 MIN READ
0
Sensationalizing no new mechanism
2 MIN READ
0
Conserved molecular mechanisms
< 1 MIN READ
0
Metaphysical science vs theory
4 MIN READ
0
Information and communication (2)
6 MIN READ
0
Viruses, amino acids, and somatic cell types
4 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
Ignoring top-down causation
2 MIN READ
0
MicroRNAs and the exposome
5 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Methylation maintains cell type differences
3 MIN READ
0
2 genes in 2 species (too expensive and too insignificant)
11 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
Correctly modeling biological energy
2 MIN READ
0
RNA-directed gene choice
5 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
0
Military combat training to fight disease (2)
3 MIN READ
0
From Hydra to humans vs a Lakatosian research program
4 MIN READ
0
Unified nutritional and molecular mechanisms
9 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Jumping back: Science or Pseudoscience?
6 MIN READ
0
Extensive molecular evidence vs ridiculous theories
2 MIN READ
0
Meaningful dialogue, anonymous fools and idiot minions
4 MIN READ
0
Sackler Colloquium: Effects or AFFECTS on Behavior
2 MIN READ
0
Systems biology and memory disorders
3 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
microRNAs differentiate neuronal cell types
3 MIN READ
0
Darwinian theories vs Darwin's facts
2 MIN READ
0
