The tipping point (revisited): 89K (5)

(click to enlarge)
Dynamic control of chirality and self-assembly of double-stranded helicates with light (2016) links light-activated microRNA biogenesis from the creation of the sun’s anti-entropic virucidal energy to RNA-mediated biophysically constrained viral latency via RNA interference.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
For a historical perspective on epigenetically-effected ATP-dependent RNA interference, see: Epigenetic Control Systems (1958)
July 15 is the anniversary date. DL Nanney presciently linked epigenetic effects of food to viral latency via Effects of Carnitine on Fatty-Acid Oxidation by Muscle (1959) and the epigenetic effects of Pheromones’: a new term for a class of biologically active substances (1959) were linked to healthy longevity in [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)]. (1994)
Moving forward, see also: Peptide ligation by chemoselective aminonitrile coupling in water 7/10/19
Our model unites prebiotic aminonitrile synthesis and biological α-peptides, suggesting that short N-acyl peptide nitriles were plausible substrates…
The endogenous substrates have been linked to the origin of platelets and the eutherian placenta.
See:Â The origin of platelets enabled the evolution of eutherian placentation 7/10/19
All neonatal mammals, regardless of how developed they are at birth, rely on maternal lactation for their initial growth and survival after birth, and thus, the survival of the mother is critical.
Platelet-linked survival of the mother can be compared to survival of the queen in eusocial insects that are also epigenetically effected by climate changes.
See: Â Climate change impacts on bumblebees converge across continents 7/10/15
Using long-term observations across Europe and North America over 110 years, we tested for climate change–related range shifts in bumblebee species across the full extents of their latitudinal and thermal limits and movements along elevation gradients.
The climate-related shifts that parallel latitudinal and thermal limits of movements along elevation gradients were linked to mammalian species via microRNAs in milk exosomes.
See: Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns 7/27/18
See also: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant 2/14/13 and Identifying Recent Adaptations in Large-Scale Genomic Data 2/14/13
The human-specific EDAR V370A allele was linked from ecological adaptations in mice and other mammals to recent adaptations in in North and East Asian and New World populations via Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk 5/8/18.
The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection…
The link from natural selection for energy-dependent codon optimality to protection from the virus-driven degradation of messenger RNA, which links mutations to all pathology has been place into the context of Global phylogeography and ancient evolution of the widespread human gut virus crAssphage and Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis
The energy-dependent creation of peptides in water has been linked from the light-activated creation of ATP, RNA to the microRNA biogenesis and the genesis of all biodiversity via the physiology of reproduction in species from microbes to humans. The origin of platelets links food energy-dependent pheromone-controlled biophysically constrained viral latency to eutherian placentation via ecological adaptations across continents that link the EDAR V370A allele from the mouse to the human model of: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)
Natural selection for food energy-dependent codon optimality is the only known link to ~5300 years of ecological adaptations in all species on Earth.
See for comparison to claims about the automagical creation of self-replicating ribozymes made by the biologically uninformed science idiot Andrew Jones in Lipid Encapsulation of Self Replicating Ribozymes (2012)
Despite their challenges, ribozymes have made an interesting niche for themselves in the field of abiogenesis. The evolution of a successful RNA polymerase ribozyme is a lofty goal. While its discovery would not be the be-all and end-all of abiogenesis research, it would represent an important stepping stone between prebiotic chemistry and life. The encapsulation of such a ribozyme is also an important step, as it would enable a system of heredity and evolution through natural selection. Based on progress in current research, it is only a matter of time before that ribozyme is discovered.
Claims about the emergence of energy and the automagical creation of self-replicating ribozymes made by the biologically uninformed science idiot, Andrew Jones, can be compared to the claims in: Feedback loops link odor and pheromone signaling with reproduction(2005)
The feedback loops were presciently included in Darwin’s “conditions of life.”
The claims were revisited in:Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet 1/22/16 and in: miRNAs in ancient tissue specimens of the Tyrolean Iceman 12/28/16
Our first comprehensive analysis of microRNAs in ancient human tissues indicates that these stable molecules can be detected in tissue specimens after 5,300 years.
No experimental evidence of biophysically constrained viral latency extends to neo-Darwinian theories of mutation-driven evolution or theories that link Big Bang cosmology to the origin of energy as information.
Instead, Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants links microRNAs in milk exosomes the the stability of all organized genomes in the mouse to human model of nutrient-dependent pheromone-controlled reproduction from 1994. [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)].
Want more on the same topic?
Swipe/Drag Left and Right To Browse Related Posts:
Pheromone-regulated genetic processes (2)
3 MIN READ
0
The physics of existence (5)
2 MIN READ
0
Biophotonically charged life (6)
2 MIN READ
0
Codon optimality vs systemic fraud (10)
3 MIN READ
0
Codon optimality vs systemic fraud (7)
3 MIN READ
0
Codon optimality vs systemic fraud (5)
6 MIN READ
0
Epistemic corruption (9)
2 MIN READ
0
Epistemic corruption (2)
2 MIN READ
0
RNA-mediated silencing (10)
4 MIN READ
0
RNA-mediated silencing (8)
2 MIN READ
0
Photonics in Forensics (4)
4 MIN READ
0
microRNA-mediated biodiversity (10)
3 MIN READ
0
Orchestrated death: Kevin J. Mitchell
2 MIN READ
0
Orchestrated death: Philip C. Ball
2 MIN READ
0
MicroRNA-mediated population control (6)
3 MIN READ
0
MicroRNA-mediated population control (5)
< 1 MIN READ
0
microRNA-mediated election cycles (3)
3 MIN READ
0
microRNA-mediated replication cycles (9)
4 MIN READ
0
microRNA-mediated replication timing (2)
2 MIN READ
0
microRNA-mediated replication timing (1)
2 MIN READ
0
Quantum Darwinism (3)
3 MIN READ
0
Life or death facts about theories (2)
< 1 MIN READ
0
Racist fascism vs individual liberty (1)
3 MIN READ
0
Protonated RNA interference vs stupid theories (6)
4 MIN READ
0
Protonated RNA interference vs stupid theories (2)
3 MIN READ
0
From optoribogenetics to HelioRiboGenetics (4)
< 1 MIN READ
0
Coherently organized healthy longevity (1)
4 MIN READ
0
pH-dependent viral latency (6)
5 MIN READ
0
Vaccines do not control pandemics (1)
3 MIN READ
0
The tipping point (revisited): 100K (3)
3 MIN READ
0
The tipping point (revisited): 100K (2)
5 MIN READ
0
The tipping point (revisited): 100K (1)
4 MIN READ
0
FDA’s ignorance: From roots to shoots (1)
6 MIN READ
0
Transposons: crossroads, crosstalk and gene regulation
7 MIN READ
0
Virus-driven reduction of RNA polymerase II occupancy in hosts (2)
5 MIN READ
0
Virus-driven reduction of RNA polymerase II occupancy in hosts (1)
2 MIN READ
0
From Wuhan to you (5)
3 MIN READ
0
Viral microRNA-mediated pathology (2)
3 MIN READ
0
Bruce McEwen’s retrovirus legacy (2)
< 1 MIN READ
0
Bruce McEwen’s legacy: sympatric speciation (3)
3 MIN READ
0
A microRNA-mediated healthy New Year! Thank God (2)
6 MIN READ
0
Light-activated PTEN-dependent viral latency (2)
4 MIN READ
0
Light-activated PTEN-dependent viral latency (1)
4 MIN READ
0
microRNAs Constrain Virus-driven Pathology (3)
4 MIN READ
0
MicroRNA-mediated hypoxia vs cancer (2)
3 MIN READ
0
#SFN2019 to 2012: Hiding the facts (1)
3 MIN READ
0
Multigenerational epigenetic inheritance (4)
4 MIN READ
0
Multigenerational epigenetic inheritance (2)
3 MIN READ
0
Chemogenetic kinetics (2): Extinction
6 MIN READ
0
Chemogenetic kinetics (1): Creation
3 MIN READ
0
Nutrient-dependent Pheromone-controlled cures (2)
4 MIN READ
0
Lewis Thomas (revisited): 90K (7)
3 MIN READ
0
The tipping point (revisited) 90K (4)
4 MIN READ
0
Sunlight, hydrophobicity and biodiversity (3)
5 MIN READ
0
Bastardized health care (4)
4 MIN READ
0
The tipping point (revisited): 89K (4)
3 MIN READ
0
Anthony S. Fauci refutes theistic evolution
3 MIN READ
0
The tipping point (revisited): 87K (1)
6 MIN READ
0
The tipping point (revisited): Big Data (2)
2 MIN READ
0
Combating ignorance to fight disease (1)
4 MIN READ
0
Virus-driven downsizing of the human brain (5)
5 MIN READ
0
RNA processing and disease (3)
3 MIN READ
0
Ecological adaptation vs neo-Darwinian nonsense (4)
2 MIN READ
0
Darwin Day 2019 (4) #darwinday2019
3 MIN READ
0
Darwin Day 2019 (3) #darwinday2019
3 MIN READ
0
Blood music orchestrates human life (3)
3 MIN READ
0
Do not call me Ishmael (3)
3 MIN READ
0
10,000 reasons to believe in biophysical constraints (revisited)
< 1 MIN READ
0
Phytoremediation, Microbiome and CRISPR (4)
4 MIN READ
0
Autophagy automagically prevents cancer (2)
2 MIN READ
0
Light-activated constrained biodiversity
7 MIN READ
0
Light-activated carbon fixation (2)
3 MIN READ
0
The tipping point (revisited): 82,000 publications (3)
2 MIN READ
0
Science journalism: a threat to humanity (1)
3 MIN READ
0
Code Biology vs Predatory Publishing (2)
2 MIN READ
0
Two photon-linked biodiversity (4)
2 MIN READ
0
The tipping point (revisited): 81,000 publications (5)
2 MIN READ
0
From microRNA.pro to quantumsouls.pro (3)
5 MIN READ
0
From microRNA.pro to quantumsouls.pro (1)
4 MIN READ
0
Hide and seek with science facts (1)
4 MIN READ
0
Hide and seek with science facts (3)
2 MIN READ
0
Darwin’s Children (2003) and Denton’s Children of the Light (2)
5 MIN READ
0
Bottom-up biology
3 MIN READ
0
North Korea quietly thanks God that Trump is a Creationist (2)
3 MIN READ
0
Happy Veteran’s Day 2018 (2)
4 MIN READ
0
I can’t fix stupid (1)
< 1 MIN READ
0
MicroRNA biogenesis protects us from HERVs (3)
5 MIN READ
0
Using gobbledygook to frighten people
4 MIN READ
0
Copying Nature’s Design Process (3)
2 MIN READ
0
Energy-dependent enzyme catalysis
4 MIN READ
0
Estranged ‘White Coat Notes’ blogger exposes human idiocy (1)
5 MIN READ
0
Virus-driven genome engineering causes cancer?
2 MIN READ
0
The tipping point (revisited): 74,000 publications
4 MIN READ
0
Laws of Biology vs no Laws of Physics (2)
3 MIN READ
0
The eternal significance of microRNAs and the Vietnam Memorial (1)
3 MIN READ
0
Epigenetic inheritance of spatiotemporal regulation (3)
5 MIN READ
0
The eternal significance of microRNAs (5)
2 MIN READ
0
ATP and RNA-mediated chromosomal stability
3 MIN READ
0
Ecological adaptations vs the randomness of evolution (3)
4 MIN READ
0
A single base change refutes theistic evolution
5 MIN READ
0
The poetry of human genome creation
< 1 MIN READ
0
Environmental selection is natural selection
3 MIN READ
0
MicroRNA-mediated denuclearization (6)
2 MIN READ
0
MicroRNA-mediated denuclearization (4)
2 MIN READ
0
NSF’s parrot and other parrots
2 MIN READ
0
Diet-driven RNA interference and mental health (4)
8 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (9)
4 MIN READ
0
Diet-driven RNA interference and mental health (2)
3 MIN READ
0
Diet-driven RNA interference and cancer prevention (3)
6 MIN READ
0
Autophagy is the antiphage defense strategy (2)
4 MIN READ
0
Interethnic genetic similarities and differences (2)
4 MIN READ
0
Enzyme-constrained interethnic biodiversity (6)
8 MIN READ
0
A mental health problem at the highest level
2 MIN READ
0
Exome Sequencing Impact in Routine Care
4 MIN READ
0
Losers: rediscovering an epigenetic key
2 MIN READ
0
Energy-dependent structure and function: Until death (3)
3 MIN READ
0
Energy-dependent structure and function: Until death (2)
5 MIN READ
0
Energy-dependent structure and function: Until death (1)
4 MIN READ
0
Predicting who wins the 2017 Nobel Prizes (7)
4 MIN READ
0
Predicting who wins the 2017 Nobel Prizes (6)
5 MIN READ
0
Predicting who wins the 2017 Nobel Prizes
4 MIN READ
0
Life and death via chemical effects on photosynthesis
8 MIN READ
0
Sci-Hub vs limits on the dissemination of information
6 MIN READ
0
Host-derived creation of all pathology (2 of 2)
9 MIN READ
0
Can protein folding chemistry be understood by theorists?
5 MIN READ
0
Energy-dependent epigenetic translation to mRNA stability (3)
5 MIN READ
0
Energy as information and constrained endogenous RNA interference (4)
7 MIN READ
0
Energy-dependent microRNA biogenesis
4 MIN READ
0
Functionally interdependent editing and methylation
4 MIN READ
0
Cytosis: Biology Content
7 MIN READ
0
Wikipedia refutes theistic evolution
4 MIN READ
0
May the anti-entropic force of sunlight be with you
4 MIN READ
0
Francis S. Collins refutes theistic evolution
6 MIN READ
0
Energy is information. Objections over ruled. You’re fired!
7 MIN READ
0
Mitochondria do not adapt
2 MIN READ
0
Critical values expose virus-driven energy theft (2)
4 MIN READ
0
Critical values expose virus-driven energy theft
6 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
RNAi: From magic bullet to billion dollar baby
4 MIN READ
0
Virus-driven energy theft: definition?
5 MIN READ
0
Human pheromone deniers: What’s next?
5 MIN READ
0
Finding odor and taste receptors everywhere
6 MIN READ
0
Nutrient-dependent RNA interference
4 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0