Lewis Thomas (revisited): 90K (7)

By: James V. Kohl | Published on: August 26, 2019

Epigenetic effects on the light-activated microRNA-mediated creation of enzymes, hormones, and receptors et al., affect the behavior of all living genera.
See: Pheromones and Nutritional Signals Regulate the Developmental Reliance on let-7 Family MicroRNAs in C. elegans 5/16/19

  …pheromones correct heterochronic developmental cell lineage defects…”

The link to food energy-dependent biophysically constrained sympatric speciation is perfectly clear. For a historical perspective see:
Pheromonal Regulation of Genetic Processes: Research on the House Mouse (Mus musculus L.) (1994)

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

The existence of light-activated inter-organism systems of genetic regulation has been relatively ignored for ~25 more years, which is the time it takes to raise another generation of biologically uninformed science idiots.
See for review: Ignoring light-activated microRNA biogenesis 10/16/18

He frames his claims in the context of random mutations and evolved biodiversity despite the facts that serious scientists have detailed. For example, ages 10+ can learn how the creation of subatomic particles must be linked from cytosis to biophysically constrained viral latency and sympatric speciation.

The physiology of reproduction is linked to heredity in species from soil bacteria to humans via EDAR V370A (an amino acid substitution) in mice; in populations found in North and East Asia; and in populations in the New World.

I could go on about the facts about cell type differentiation for hours or refer you to MicroRNA.pro or one of my other domains. Alternatively, you could see the work that was published today: “MicroRNAs buffer genetic variation at specific temperatures during embryonic development” for comparison to our 1996 review of molecular epigenetics: “From Fertilization to Adult Sexual Behavior”

In less than one year more than 11,000 publications on microRNAs (Clear all filters to show 90712 items) have helped to link the light-activated creation of microRNAs to 10 specific single-base changes at four different locations that biophysically constrain the transgenerational epigenetic inheritance of ethnicity-linked obesity.
See: A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity 7/5/19

Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than ten SNPs (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci.

The transgenerational epigenetic inheritance of ethnicity-linked obesity is the link from what human populations eat to their pheromone-controlled physiology of reproduction and biophysically constrained viral latency in species from soil microbes to mammals.
The virus-driven degradation of messenger RNA causes the mutations linked to differences in diseases via ethnicity.
All the difference appear to have arisen during the past 5-10,000 years.
See: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
See also: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk 4/23/18
I reiterate:
See: Pheromones and Nutritional Signals Regulate the Developmental Reliance on let-7 Family MicroRNAs in C. elegans 5/16/19

  …pheromones correct heterochronic developmental cell lineage defects…”

See for review:
Aug 25th, Lewis Thomas (revisited): 90K (6)
Aug 25th, Lewis Thomas (revisited): 90K (5)
Aug 23rd, Lewis Thomas (revisited): 90K (4)
Aug 23rd, Lewis Thomas (revisited): 90K (3)
Aug 23rd, Lewis Thomas (revisited): 90K (2)
Aug 23rd, Lewis Thomas (revisited): 90K (1)
See the series in prep: The Nutrient-dependent Pheromone-controlled cure (1)


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